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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.UniRule annotation

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl), 6-phosphogluconolactonase (pgl_3)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd_1)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonaseUniRule annotation (EC:3.1.1.31UniRule annotation)
Short name:
6-P-gluconolactonaseUniRule annotation
Gene namesi
Name:pglUniRule annotation
Ordered Locus Names:SG0900
OrganismiSodalis glossinidius (strain morsitans)
Taxonomic identifieri343509 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaeSodalis
Proteomesi
  • UP000001932 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002914731 – 3316-phosphogluconolactonaseAdd BLAST331

Interactioni

Protein-protein interaction databases

STRINGi343509.SG0900

Structurei

3D structure databases

ProteinModelPortaliQ2NUK0
SMRiQ2NUK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105HHQ Bacteria
COG2706 LUCA
HOGENOMiHOG000257418
KOiK07404
OMAiEGNWPRD
OrthoDBiPOG091H07R3

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_01605 6P_gluconolactonase, 1 hit
InterProiView protein in InterPro
IPR022528 6-phosphogluconolactonase_YbhE
IPR019405 Lactonase_7-beta_prop
IPR011045 N2O_reductase_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF10282 Lactonase, 1 hit
SUPFAMiSSF50974 SSF50974, 1 hit

Sequencei

Sequence statusi: Complete.

Q2NUK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQIVYVASP ESQQIHVWQM DNQGALTLLQ VVDTPGQGQP MVIHPARTHL
60 70 80 90 100
YIGVRPSFGV VSYRIDEKGL LTEAGMAPLP GSPTQLTTDL QGETLYSVSY
110 120 130 140 150
SGSCLSVSPI DEQGIVGAPT QTLEGLTHCH SANVDTTNQV LWVPCLQEDR
160 170 180 190 200
IRLYTIGEAG HLTPRTPEAL DSVAGAGPRH MVFHHGGGYA YAINELSGTV
210 220 230 240 250
NVIAIDAAGA GPRIVQTLDI MPAGFSDTRW AADIYITPDG RWLYCCDRTA
260 270 280 290 300
SVISRFAVSE DGGVLRLLGH QATESQPRGF NIDSQGRFLV AAGQKSHHIA
310 320 330
VYAIDAQSGA LDPLARYAVG QGPMWVSVLA R
Length:331
Mass (Da):35,497
Last modified:February 7, 2006 - v1
Checksum:iFBCA285148940C20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008232 Genomic DNA Translation: BAE74175.1
RefSeqiWP_011410761.1, NC_007712.1

Genome annotation databases

EnsemblBacteriaiBAE74175; BAE74175; SG0900
KEGGisgl:SG0900

Similar proteinsi

Entry informationi

Entry namei6PGL_SODGM
AccessioniPrimary (citable) accession number: Q2NUK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 7, 2006
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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