true2009-07-282024-03-27109BIOB_SODGMMassive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host.Toh H.Weiss B.L.Perkin S.A.H.Yamashita A.Oshima K.Hattori M.Aksoy S.doi:10.1101/gr.41061062006Genome Res.16149-156NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]morsitansBacteriaRadical_SAMAldolase class IBioBAldolase_TIMBATS_domBiotin_synth/BioABBiotin_synthaseElp3/MiaA/NifB-like_rSAMrSAMbioBBIOTIN SYNTHASEBIOTIN SYNTHASE, MITOCHONDRIALBATSRadical_SAMBiotin_synthbiotin_synthasebiotin_synthase_likeBATSElp3Radical SAM enzymesRADICAL_SAMBiotin synthase2.8.1.6bioBSG0903Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.Homodimer.Belongs to the radical SAM superfamily. Biotin synthase family.Biotin synthase383591345Radical SAM core38256535760971281882604Fe-4S-S-AdoMet2006-02-07138359a4d72780a8269fb0bbf1d1c71b405019MSTSQRWTQAQARALFDKPFLELLFEAQQVHRQHFTPGEVQVSTLLSIKTGACPEDCKYCPQSARYSTGLESERLMQVQQVLDAARKARDAGSTRFCMGAAWKNPHDRDMPLLEQMVQGVKAMGLETCMTLGMLNDRQVQRLAEAGLDFYNHNLDTSPEFYGSIVTTRSYQDRLDTLSKVRQAGIKVCSGGIVGLGEDIRDRAGLLVQLANLPTPPESVPINMLVKVKGTPLADNEDVDPFEFIRTIAVARIMMPRSHVRLSAGREQMNEQTQALCFMAGANSVFYGCKLLTTPNPGEDRDMALFHKLGINIERRTATQGDVAQQAQLAEELLTADTAHYYNAARtruetrue