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Q2NUE3 (GCH1_SODGM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:SG0957
OrganismSodalis glossinidius (strain morsitans) [Complete proteome] [HAMAP]
Taxonomic identifier343509 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 221221GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_1000043743

Sites

Metal binding1091Zinc By similarity
Metal binding1121Zinc By similarity
Metal binding1801Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2NUE3 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 8CF6B5310E3E46D6

FASTA22124,830
        10         20         30         40         50         60 
MVTLTKEASQ VRDALLARGL ETPLRGEVLD NEVRKRLIAE HMTEIMTLLN LDLTDDSLAE 

        70         80         90        100        110        120 
TPHRIAKMYV EEIFAGLDYA NFPKITVIEN KMKVDEMVTV RDITLTSTCE HHFVIIDGKA 

       130        140        150        160        170        180 
TVSYIPKHCV IGLSKINRIV QFFAQRPQVQ ERLTQQIMLA LQTLLGTNNV AVSIDAVHYC 

       190        200        210        220 
VKARGIRDAT STTTITSLGG LFKSSQNTRQ EFLRAVTHYN G 

« Hide

References

[1]"Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: morsitans.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008232 Genomic DNA. Translation: BAE74232.1.
RefSeqYP_454637.1. NC_007712.1.

3D structure databases

ProteinModelPortalQ2NUE3.
SMRQ2NUE3. Positions 3-220.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING343509.SG0957.

Proteomic databases

PRIDEQ2NUE3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE74232; BAE74232; SG0957.
GeneID3868444.
KEGGsgl:SG0957.
PATRIC23649804. VBISodGlo61428_2211.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
KOK01495.
OMAQRIAEHM.
OrthoDBEOG6XHC8G.

Enzyme and pathway databases

BioCycSGLO343509:GJJC-999-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_SODGM
AccessionPrimary (citable) accession number: Q2NUE3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways