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Q2NUE3

- GCH1_SODGM

UniProt

Q2NUE3 - GCH1_SODGM

Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi109 – 1091ZincUniRule annotation
    Metal bindingi112 – 1121ZincUniRule annotation
    Metal bindingi180 – 1801ZincUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
    2. one-carbon metabolic process Source: UniProtKB-HAMAP
    3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    GTP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciSGLO343509:GJJC-999-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase 1UniRule annotation (EC:3.5.4.16UniRule annotation)
    Alternative name(s):
    GTP cyclohydrolase IUniRule annotation
    Short name:
    GTP-CH-IUniRule annotation
    Gene namesi
    Name:folEUniRule annotation
    Ordered Locus Names:SG0957
    OrganismiSodalis glossinidius (strain morsitans)
    Taxonomic identifieri343509 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis
    ProteomesiUP000001932: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 221221GTP cyclohydrolase 1PRO_1000043743Add
    BLAST

    Proteomic databases

    PRIDEiQ2NUE3.

    Interactioni

    Subunit structurei

    Toroid-shaped homodecamer, composed of two pentamers of five dimers.By similarity

    Protein-protein interaction databases

    STRINGi343509.SG0957.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2NUE3.
    SMRiQ2NUE3. Positions 3-220.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase I family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0302.
    KOiK01495.
    OMAiQRIAEHM.
    OrthoDBiEOG6XHC8G.

    Family and domain databases

    HAMAPiMF_00223. FolE.
    InterProiIPR001474. GTP_CycHdrlase_I.
    IPR018234. GTP_CycHdrlase_I_CS.
    IPR020602. GTP_CycHdrlase_I_dom.
    [Graphical view]
    PANTHERiPTHR11109. PTHR11109. 1 hit.
    PfamiPF01227. GTP_cyclohydroI. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00063. folE. 1 hit.
    PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
    PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2NUE3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTLTKEASQ VRDALLARGL ETPLRGEVLD NEVRKRLIAE HMTEIMTLLN    50
    LDLTDDSLAE TPHRIAKMYV EEIFAGLDYA NFPKITVIEN KMKVDEMVTV 100
    RDITLTSTCE HHFVIIDGKA TVSYIPKHCV IGLSKINRIV QFFAQRPQVQ 150
    ERLTQQIMLA LQTLLGTNNV AVSIDAVHYC VKARGIRDAT STTTITSLGG 200
    LFKSSQNTRQ EFLRAVTHYN G 221
    Length:221
    Mass (Da):24,830
    Last modified:February 7, 2006 - v1
    Checksum:i8CF6B5310E3E46D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008232 Genomic DNA. Translation: BAE74232.1.
    RefSeqiWP_011410818.1. NC_007712.1.
    YP_454637.1. NC_007712.1.

    Genome annotation databases

    EnsemblBacteriaiBAE74232; BAE74232; SG0957.
    GeneIDi3868444.
    KEGGisgl:SG0957.
    PATRICi23649804. VBISodGlo61428_2211.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008232 Genomic DNA. Translation: BAE74232.1 .
    RefSeqi WP_011410818.1. NC_007712.1.
    YP_454637.1. NC_007712.1.

    3D structure databases

    ProteinModelPortali Q2NUE3.
    SMRi Q2NUE3. Positions 3-220.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 343509.SG0957.

    Proteomic databases

    PRIDEi Q2NUE3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE74232 ; BAE74232 ; SG0957 .
    GeneIDi 3868444.
    KEGGi sgl:SG0957.
    PATRICi 23649804. VBISodGlo61428_2211.

    Phylogenomic databases

    eggNOGi COG0302.
    KOi K01495.
    OMAi QRIAEHM.
    OrthoDBi EOG6XHC8G.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci SGLO343509:GJJC-999-MONOMER.

    Family and domain databases

    HAMAPi MF_00223. FolE.
    InterProi IPR001474. GTP_CycHdrlase_I.
    IPR018234. GTP_CycHdrlase_I_CS.
    IPR020602. GTP_CycHdrlase_I_dom.
    [Graphical view ]
    PANTHERi PTHR11109. PTHR11109. 1 hit.
    Pfami PF01227. GTP_cyclohydroI. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00063. folE. 1 hit.
    PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
    PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
      Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
      Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: morsitans.

    Entry informationi

    Entry nameiGCH1_SODGM
    AccessioniPrimary (citable) accession number: Q2NUE3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3