ID   CDD_SODGM               Reviewed;         309 AA.
AC   Q2NUD2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Cytidine deaminase;
DE            EC=3.5.4.5;
DE   AltName: Full=Cytidine aminohydrolase;
DE            Short=CDA;
GN   Name=cdd; OrderedLocusNames=SG0968;
OS   Sodalis glossinidius (strain morsitans).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Sodalis.
OX   NCBI_TaxID=343509;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16365377; DOI=10.1101/gr.4106106;
RA   Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K.,
RA   Hattori M., Aksoy S.;
RT   "Massive genome erosion and functional adaptations provide insights
RT   into the symbiotic lifestyle of Sodalis glossinidius in the tsetse
RT   host.";
RL   Genome Res. 16:149-156(2006).
CC   -!- FUNCTION: This enzyme scavenge exogenous and endogenous cytidine
CC       and 2'-deoxycytidine for UMP synthesis (By similarity).
CC   -!- CATALYTIC ACTIVITY: Cytidine + H(2)O = uridine + NH(3).
CC   -!- COFACTOR: Binds 1 zinc ion (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase
CC       family.
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DR   EMBL; AP008232; BAE74243.1; -; Genomic_DNA.
DR   RefSeq; YP_454648.1; -.
DR   GeneID; 3867095; -.
DR   GenomeReviews; AP008232_GR; SG0968.
DR   KEGG; sgl:SG0968; -.
DR   NMPDR; fig|343509.6.peg.2011; -.
DR   HOGENOM; Q2NUD2; -.
DR   OMA; Q2NUD2; FSPCGHC.
DR   BioCyc; SGLO343509:SG0968-MON; -.
DR   GO; GO:0004126; F:cytidine deaminase activity; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046087; P:cytidine metabolic process; IEA:InterPro.
DR   HAMAP; MF_01558; -; 1.
DR   InterPro; IPR016192; APOBEC/CMP_deaminase_Zn-bd.
DR   InterPro; IPR002125; CMP_dCMP_Zn_bd.
DR   InterPro; IPR006263; Cyt_deam_dimer.
DR   InterPro; IPR013171; dC_C_deam_Zn_bd.
DR   Pfam; PF00383; dCMP_cyt_deam_1; 1.
DR   Pfam; PF08211; dCMP_cyt_deam_2; 1.
DR   TIGRFAMs; TIGR01355; cyt_deam_dimer; 1.
DR   PROSITE; PS00903; CYT_DCMP_DEAMINASES; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Metal-binding; Zinc.
FT   CHAIN         1    309       Cytidine deaminase.
FT                                /FTId=PRO_1000068970.
FT   REGION       89     91       Substrate binding (By similarity).
FT   ACT_SITE    104    104       Proton donor (By similarity).
FT   METAL       102    102       Zinc; catalytic (By similarity).
FT   METAL       129    129       Zinc; catalytic (By similarity).
FT   METAL       132    132       Zinc; catalytic (By similarity).
SQ   SEQUENCE   309 AA;  32837 MW;  9A267DF61C0391EF CRC64;
     MIARFAPALA AVSPALHTAL APLLDHHAFA GWLSAPQVKE LMQAGGLDED ALCFTLLPLA
     AAYAVTPLSH FNVGAIACGI SGNLYFGANM EFLAAPLQQT VHAEQSAIAH AWLRGEKRLR
     ALTVNYTPCG HCRQFMNELN SGTDLIICLP ERSAATLASY LPDAFGPRDL AIQSLLLDEI
     DHAFAAAAWL DHDLSAPSPD DNDPLVSTAL DAASRSHAPY SQSHSGVALQ TQDGCVYAGR
     YAENAAFNPS LPPLQTALIL MNAAGADDRQ IRRAVLAERQ NAPITQWPAT NATLAALGCH
     EVHHLSLSL
//