Reviewed, UniProtKB/Swiss-Prot Q2NUD2 (CDD_SODGM)

Names and origin

Protein names

Recommended name:
    Cytidine deaminase
    EC=3.5.4.5
Alternative name(s):
    Cytidine aminohydrolase
      Short name=CDA

Gene names

Name:	cdd
Ordered Locus Names:	SG0968

Organism

Sodalis glossinidius (strain morsitans) [Complete proteome] [HAMAP]

Taxonomic identifier

343509 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Sodalis

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.
Catalytic activity	Cytidine + H2O = uridine + NH3. HAMAP MF_01558
Cofactor	Binds 1 zinc ion By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytidine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Cytidine deaminase HAMAP MF_01558		PRO_1000068970
Regions
	Region	89 – 91	3	Substrate binding By similarity
Sites
	Active site	104	1	Proton donor By similarity
	Metal binding	102	1	Zinc; catalytic By similarity
	Metal binding	129	1	Zinc; catalytic By similarity
	Metal binding	132	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2NUD2-1 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 9A267DF61C0391EF	FASTA	309	32,837
	10 20 30 40 50 60 MIARFAPALA AVSPALHTAL APLLDHHAFA GWLSAPQVKE LMQAGGLDED ALCFTLLPLA 70 80 90 100 110 120 AAYAVTPLSH FNVGAIACGI SGNLYFGANM EFLAAPLQQT VHAEQSAIAH AWLRGEKRLR 130 140 150 160 170 180 ALTVNYTPCG HCRQFMNELN SGTDLIICLP ERSAATLASY LPDAFGPRDL AIQSLLLDEI 190 200 210 220 230 240 DHAFAAAAWL DHDLSAPSPD DNDPLVSTAL DAASRSHAPY SQSHSGVALQ TQDGCVYAGR 250 260 270 280 290 300 YAENAAFNPS LPPLQTALIL MNAAGADDRQ IRRAVLAERQ NAPITQWPAT NATLAALGCH EVHHLSLSL

References

[1]

"Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host." Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S. Genome Res. 16:149-156(2006) [PubMed: 16365377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP008232 Genomic DNA. Translation: BAE74243.1.
RefSeq	YP_454648.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3867095.
GenomeReviews	Gene locus SG0968 in contig AP008232_GR.
KEGG	sgl:SG0968.
NMPDR	fig|343509.6.peg.2011.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2NUD2.
OMA	Q2NUD2. FSPCGHC.
Enzyme and pathway databases
BioCyc	SGLO343509:SG0968-MON.
Family and domain databases
HAMAP	MF_01558. [Tree]
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn_bd. IPR006263. Cyt_deam_dimer. IPR013171. dC_C_deam_Zn_bd. [Graphical view]
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. PF08211. dCMP_cyt_deam_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01355. cyt_deam_dimer. 1 hit.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_SODGM

Accession

Primary (citable) accession number: Q2NUD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 7, 2006
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)