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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi376 – 383ATP8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbA (EC:3.6.3.-)
Gene namesi
Name:msbA
Ordered Locus Names:SG0995
OrganismiSodalis glossinidius (strain morsitans)
Taxonomic identifieri343509 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaeSodalis
Proteomesi
  • UP000001932 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane ; Multi-pass membrane protein

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 48HelicalAdd BLAST23
Transmembranei63 – 83HelicalAdd BLAST21
Transmembranei153 – 173HelicalAdd BLAST21
Transmembranei253 – 273HelicalAdd BLAST21
Transmembranei275 – 295HelicalAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716591 – 582Lipid A export ATP-binding/permease protein MsbAAdd BLAST582

Proteomic databases

PRIDEiQ2NUA5.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi343509.SG0995.

Structurei

3D structure databases

ProteinModelPortaliQ2NUA5.
SMRiQ2NUA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 310ABC transmembrane type-1Add BLAST284
Domaini342 – 578ABC transporterAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiSPLMEFL.
OrthoDBiPOG091H00DB.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2NUA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNDKDLSTW QTFRRLWPMI SPFKTGLIVA AIALILNAAS DTFMLSLLKP
60 70 80 90 100
LLDDGFGKAN SNILVWMPLV VIGLMVLRGV SGFVSSYCVS WVSGKVIMNM
110 120 130 140 150
RRRLFNHMMD MPVSFFDQQS TGTLLSRITY DSEQVASSSS GALITVIREG
160 170 180 190 200
ASIIGLFAMM FYYSWQLSLI LVVIAPVVSF AIRQVSKRFR QISKRMQNTM
210 220 230 240 250
GQVTTSAEQM LKGHKEVLIF GGQKVENERF NSVSNRMRQQ GMKMVAASSV
260 270 280 290 300
SDPLIQFIAS LALAFVLYAA SFPSVMETLT AGTITVVFSS MIALMRPLKS
310 320 330 340 350
LTNVNAQFQR GMAACQTLFS ILDMETEKDE GTVEVERVKG DIAFDHVTFS
360 370 380 390 400
YPGKETPSLH DISLSIPTGH TVALVGRSGS GKSTIANLLT RFYDIQQGQI
410 420 430 440 450
LLDGTDLRAY KLASLRNQVA LVSQNVHLFN DTIANNIAYA RKATYSRKQI
460 470 480 490 500
ENAARMAYAM DFIEKMDQGL DTVIGENGVL LSGGQRQRIA IARALLRDCP
510 520 530 540 550
ILILDEATSA LDTESERAIQ KALDALQKNR TSLVIAHRLS TIEKADEILV
560 570 580
VVEGRIVERG NHEELMSRQG VYAQLHQLQF GQ
Length:582
Mass (Da):64,457
Last modified:February 7, 2006 - v1
Checksum:i1D06588B280B97DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008232 Genomic DNA. Translation: BAE74270.1.
RefSeqiWP_011410856.1. NC_007712.1.

Genome annotation databases

EnsemblBacteriaiBAE74270; BAE74270; SG0995.
KEGGisgl:SG0995.

Similar proteinsi

Entry informationi

Entry nameiMSBA_SODGM
AccessioniPrimary (citable) accession number: Q2NUA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 7, 2006
Last modified: October 25, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families