Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB), Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:SG1016
OrganismiSodalis glossinidius (strain morsitans)
Taxonomic identifieri343509 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaeSodalis
Proteomesi
  • UP000001932 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000250161 – 402Nicotinate phosphoribosyltransferaseAdd BLAST402

Proteomic databases

PRIDEiQ2NU84

Interactioni

Protein-protein interaction databases

STRINGi343509.SG1016

Structurei

3D structure databases

ProteinModelPortaliQ2NU84
SMRiQ2NU84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RH7 Bacteria
COG1488 LUCA
KOiK00763
OMAiKLTMQCA
OrthoDBiPOG091H0197

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

Q2NU84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVATDPILT SILDTDAYKF HMQQAVFHRY HDVMVSAKFR CRGYELLGEY
60 70 80 90 100
AADISAQVDM MRGLQLNDDE FTYLRGLPFF QSDYLNCLRQ FRFDPSQVRI
110 120 130 140 150
RNHHGKLDIR ITGPWRDVIL WEVPLLAVIS EVVHHRRSPQ VTTADAVARL
160 170 180 190 200
RQKLLHFRRI SEDLDTSRFR LMDFGTRRRF SRQVQFEVIA ELQREFPYLI
210 220 230 240 250
GTSNYQLARE RGLPPIGTQA HEWFQAHQQI SPDLANSQSA ALQAWLDEYP
260 270 280 290 300
DRLGIALTDC ITMDAFLRDF GPSFARAYQG MRHDSGDPVE WGEKAIAHYQ
310 320 330 340 350
QLGIDPLTKT LVFSDSLDFD KAFMLYRHFW QRINLVFGIG TRLTCDIPGI
360 370 380 390 400
KPLNIVIKLV KCNGKPVAKL SDSPGKIMCH DKAFVRALRK AFDVPLVVKK

AS
Length:402
Mass (Da):46,361
Last modified:February 7, 2006 - v1
Checksum:i98F4B4CBAEE87F34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008232 Genomic DNA Translation: BAE74291.1

Genome annotation databases

EnsemblBacteriaiBAE74291; BAE74291; SG1016
KEGGisgl:SG1016

Similar proteinsi

Entry informationi

Entry nameiPNCB_SODGM
AccessioniPrimary (citable) accession number: Q2NU84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: April 25, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health