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Q2NU84

- PNCB_SODGM

UniProt

Q2NU84 - PNCB_SODGM

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Protein
Nicotinate phosphoribosyltransferase
Gene
pncB, SG1016
Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate phosphoribosyltransferase activity Source: InterPro
  3. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciSGLO343509:GJJC-1058-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:pncB
Ordered Locus Names:SG1016
OrganismiSodalis glossinidius (strain morsitans)
Taxonomic identifieri343509 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis
ProteomesiUP000001932: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Nicotinate phosphoribosyltransferaseUniRule annotation
PRO_1000025016Add
BLAST

Proteomic databases

PRIDEiQ2NU84.

Interactioni

Protein-protein interaction databases

STRINGi343509.SG1016.

Structurei

3D structure databases

ProteinModelPortaliQ2NU84.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2NU84-1 [UniParc]FASTAAdd to Basket

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MNVATDPILT SILDTDAYKF HMQQAVFHRY HDVMVSAKFR CRGYELLGEY    50
AADISAQVDM MRGLQLNDDE FTYLRGLPFF QSDYLNCLRQ FRFDPSQVRI 100
RNHHGKLDIR ITGPWRDVIL WEVPLLAVIS EVVHHRRSPQ VTTADAVARL 150
RQKLLHFRRI SEDLDTSRFR LMDFGTRRRF SRQVQFEVIA ELQREFPYLI 200
GTSNYQLARE RGLPPIGTQA HEWFQAHQQI SPDLANSQSA ALQAWLDEYP 250
DRLGIALTDC ITMDAFLRDF GPSFARAYQG MRHDSGDPVE WGEKAIAHYQ 300
QLGIDPLTKT LVFSDSLDFD KAFMLYRHFW QRINLVFGIG TRLTCDIPGI 350
KPLNIVIKLV KCNGKPVAKL SDSPGKIMCH DKAFVRALRK AFDVPLVVKK 400
AS 402
Length:402
Mass (Da):46,361
Last modified:February 7, 2006 - v1
Checksum:i98F4B4CBAEE87F34
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008232 Genomic DNA. Translation: BAE74291.1.
RefSeqiYP_454696.1. NC_007712.1.

Genome annotation databases

EnsemblBacteriaiBAE74291; BAE74291; SG1016.
GeneIDi3866380.
KEGGisgl:SG1016.
PATRICi23650034. VBISodGlo61428_2327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008232 Genomic DNA. Translation: BAE74291.1 .
RefSeqi YP_454696.1. NC_007712.1.

3D structure databases

ProteinModelPortali Q2NU84.
ModBasei Search...

Protein-protein interaction databases

STRINGi 343509.SG1016.

Proteomic databases

PRIDEi Q2NU84.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE74291 ; BAE74291 ; SG1016 .
GeneIDi 3866380.
KEGGi sgl:SG1016.
PATRICi 23650034. VBISodGlo61428_2327.

Phylogenomic databases

eggNOGi COG1488.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci SGLO343509:GJJC-1058-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
    Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
    Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: morsitans.

Entry informationi

Entry nameiPNCB_SODGM
AccessioniPrimary (citable) accession number: Q2NU84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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