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Q2NU84

- PNCB_SODGM

UniProt

Q2NU84 - PNCB_SODGM

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciSGLO343509:GJJC-1058-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:SG1016
    OrganismiSodalis glossinidius (strain morsitans)
    Taxonomic identifieri343509 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis
    ProteomesiUP000001932: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 402402Nicotinate phosphoribosyltransferasePRO_1000025016Add
    BLAST

    Proteomic databases

    PRIDEiQ2NU84.

    Interactioni

    Protein-protein interaction databases

    STRINGi343509.SG1016.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2NU84.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    KOiK00763.
    OMAiQAVFHRY.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2NU84-1 [UniParc]FASTAAdd to Basket

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    MNVATDPILT SILDTDAYKF HMQQAVFHRY HDVMVSAKFR CRGYELLGEY    50
    AADISAQVDM MRGLQLNDDE FTYLRGLPFF QSDYLNCLRQ FRFDPSQVRI 100
    RNHHGKLDIR ITGPWRDVIL WEVPLLAVIS EVVHHRRSPQ VTTADAVARL 150
    RQKLLHFRRI SEDLDTSRFR LMDFGTRRRF SRQVQFEVIA ELQREFPYLI 200
    GTSNYQLARE RGLPPIGTQA HEWFQAHQQI SPDLANSQSA ALQAWLDEYP 250
    DRLGIALTDC ITMDAFLRDF GPSFARAYQG MRHDSGDPVE WGEKAIAHYQ 300
    QLGIDPLTKT LVFSDSLDFD KAFMLYRHFW QRINLVFGIG TRLTCDIPGI 350
    KPLNIVIKLV KCNGKPVAKL SDSPGKIMCH DKAFVRALRK AFDVPLVVKK 400
    AS 402
    Length:402
    Mass (Da):46,361
    Last modified:February 7, 2006 - v1
    Checksum:i98F4B4CBAEE87F34
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008232 Genomic DNA. Translation: BAE74291.1.
    RefSeqiYP_454696.1. NC_007712.1.

    Genome annotation databases

    EnsemblBacteriaiBAE74291; BAE74291; SG1016.
    GeneIDi3866380.
    KEGGisgl:SG1016.
    PATRICi23650034. VBISodGlo61428_2327.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008232 Genomic DNA. Translation: BAE74291.1 .
    RefSeqi YP_454696.1. NC_007712.1.

    3D structure databases

    ProteinModelPortali Q2NU84.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 343509.SG1016.

    Proteomic databases

    PRIDEi Q2NU84.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE74291 ; BAE74291 ; SG1016 .
    GeneIDi 3866380.
    KEGGi sgl:SG1016.
    PATRICi 23650034. VBISodGlo61428_2327.

    Phylogenomic databases

    eggNOGi COG1488.
    KOi K00763.
    OMAi QAVFHRY.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci SGLO343509:GJJC-1058-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
      Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
      Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: morsitans.

    Entry informationi

    Entry nameiPNCB_SODGM
    AccessioniPrimary (citable) accession number: Q2NU84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3