Q2NTX3 (HIS7_SODGM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histidine biosynthesis bifunctional protein hisB

Including the following 2 domains:

1. Histidinol-phosphatase
   EC=3.1.3.15
2. Imidazoleglycerol-phosphate dehydratase
   Short name=IGPD
   EC=4.2.1.19

Gene names

Name:	hisB
Ordered Locus Names:	SG1127

Organism

Sodalis glossinidius (strain morsitans) [Complete proteome] [HAMAP]

Taxonomic identifier

343509 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Sodalis

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. HAMAP MF_01022 L-histidinol phosphate + H2O = L-histidinol + phosphate. HAMAP MF_01022
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. HAMAP MF_01022 Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.
Subcellular location	Cytoplasm By similarity HAMAP MF_01022.
Sequence similarities	In the N-terminal section; belongs to the histidinol-phosphatase family. In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Hydrolase Lyase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histidinol-phosphatase activity Inferred from electronic annotation. Source: EC imidazoleglycerol-phosphate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 355	355	Histidine biosynthesis bifunctional protein hisB HAMAP MF_01022		PRO_1000063449
Regions
	Region	1 – 166	166	Histidinol-phosphatase HAMAP MF_01022
	Region	167 – 355	189	Imidazoleglycerol-phosphate dehydratase HAMAP MF_01022

Sequences

	Sequence		Length	Mass (Da)
	Q2NTX3 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 0BDC33A77F10CC7E	FASTA	355	39,469
	10 20 30 40 50 60 MNQKVLFIDR DGTLINEPPA DFQVDRMDKL ALEPGVIPVL LALQKAGFRL VMITNQDGLG 70 80 90 100 110 120 TTSFPQADFD GPHDLMMAIF TSQGIVFDEV LICPHLPTDG CACRKPQTGI VTPWLKEHAL 130 140 150 160 170 180 DSAHSYVIGD RETDMALAAN MGITGLRYQR ASLNWPAIGE QLTRSDRHAR VNRVTRETAI 190 200 210 220 230 240 DVEVWLDREG DSRINTGIGF FDHMLDQIAT HGGLRINIAV KGDLHIDDHH TVEDTALALG 250 260 270 280 290 300 EALNKALGDK RGIGRFGFVL PMDECLARCA LDISGRPHLE YKAKYSFQRV GDLSTEMVEH 310 320 330 340 350 FFRSLSYAMA CTLHLRTKGK NDHHRVESLF KAFGRTLRQA IRVEGDTLPS SKGVL

References

[1]

"Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host." Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S. Genome Res. 16:149-156(2006) [PubMed: 16365377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: morsitans.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008232 Genomic DNA. Translation: BAE74402.1.
RefSeq	YP_454807.1. NC_007712.1.
3D structure databases
ProteinModelPortal	Q2NTX3.
SMR	Q2NTX3. Positions 3-164, 167-344.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2NTX3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3867555.
GenomeReviews	Gene locus SG1127 in contig AP008232_GR.
KEGG	sgl:SG1127.
NMPDR	fig|343509.6.peg.2310.
PATRIC	23650510. VBISodGlo61428_2564.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0131.
HOGENOM	HBG289010.
OMA	EMVPHFF.
PhylomeDB	Q2NTX3.
ProtClustDB	PRK05446.
Enzyme and pathway databases
BioCyc	SGLO343509:SG1127-MONOMER.
Family and domain databases
HAMAP	MF_01022. Bifunc_HisB. [Tree]
InterPro	IPR023214. HAD-like_dom. IPR006549. HAD-SF_hydro_IIIA. IPR020566. His_synth_bifunc_HisB. IPR005954. HisB_N. IPR006543. Histidinol-phos. IPR000807. ImidazoleglycerolP_deHydtase. IPR020565. ImidazoleglycerP_deHydtase_CS. IPR013954. PNK3P. IPR020568. Ribosomal_S5_D2-typ_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.1000. HAD-like_dom. 1 hit.
KO	K01089.
PANTHER	PTHR23133:SF2. Imidazole-GPD. 1 hit.
Pfam	PF00475. IGPD. 1 hit. PF08645. PNK3P. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
TIGRFAMs	TIGR01662. HAD-SF-IIIA. 1 hit. TIGR01261. HisB_Nterm. 1 hit. TIGR01656. Histidinol-ppas. 1 hit.
PROSITE	PS00954. IGP_DEHYDRATASE_1. 1 hit. PS00955. IGP_DEHYDRATASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS7_SODGM

Accession

Primary (citable) accession number: Q2NTX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 7, 2006
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program