Reviewed, UniProtKB/Swiss-Prot Q2NTX3 (HIS7_SODGM)

Names and origin

Protein names

Recommended name:
    Histidine biosynthesis bifunctional protein hisB
Including the following 2 domains:
    1- Recommended name:
            Histidinol-phosphatase
              EC=3.1.3.15
    2- Recommended name:
            Imidazoleglycerol-phosphate dehydratase
                Short name=IGPD
              EC=4.2.1.19

Gene names

Name:	hisB
Ordered Locus Names:	SG1127

Organism

Sodalis glossinidius (strain morsitans) [Complete proteome] [HAMAP]

Taxonomic identifier

343509 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Sodalis

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. HAMAP MF_01022 L-histidinol phosphate + H2O = L-histidinol + phosphate. HAMAP MF_01022
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. HAMAP MF_01022 Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	In the N-terminal section; belongs to the histidinol-phosphatase family. In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Hydrolase Lyase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histidinol-phosphatase activity Inferred from electronic annotation. Source: HAMAP imidazoleglycerol-phosphate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 355	355	Histidine biosynthesis bifunctional protein hisB HAMAP MF_01022		PRO_1000063449
Regions
	Region	1 – 166	166	Histidinol-phosphatase HAMAP MF_01022
	Region	167 – 355	189	Imidazoleglycerol-phosphate dehydratase HAMAP MF_01022

Sequences

	Sequence		Length	Mass (Da)
	Q2NTX3-1 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 0BDC33A77F10CC7E	FASTA	355	39,469
	10 20 30 40 50 60 MNQKVLFIDR DGTLINEPPA DFQVDRMDKL ALEPGVIPVL LALQKAGFRL VMITNQDGLG 70 80 90 100 110 120 TTSFPQADFD GPHDLMMAIF TSQGIVFDEV LICPHLPTDG CACRKPQTGI VTPWLKEHAL 130 140 150 160 170 180 DSAHSYVIGD RETDMALAAN MGITGLRYQR ASLNWPAIGE QLTRSDRHAR VNRVTRETAI 190 200 210 220 230 240 DVEVWLDREG DSRINTGIGF FDHMLDQIAT HGGLRINIAV KGDLHIDDHH TVEDTALALG 250 260 270 280 290 300 EALNKALGDK RGIGRFGFVL PMDECLARCA LDISGRPHLE YKAKYSFQRV GDLSTEMVEH 310 320 330 340 350 FFRSLSYAMA CTLHLRTKGK NDHHRVESLF KAFGRTLRQA IRVEGDTLPS SKGVL

References

[1]

"Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host." Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S. Genome Res. 16:149-156(2006) [PubMed: 16365377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP008232 Genomic DNA. Translation: BAE74402.1.
RefSeq	YP_454807.1.
3D structure databases
SMR	Q2NTX3. Positions 3-164.
ModBase	Search...
Genome annotation databases
GeneID	3867555.
GenomeReviews	Gene locus SG1127 in contig AP008232_GR.
KEGG	sgl:SG1127.
NMPDR	fig|343509.6.peg.2310.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2NTX3.
OMA	Q2NTX3. MVSNQDG.
Enzyme and pathway databases
BioCyc	SGLO343509:SG1127-MON.
Family and domain databases
HAMAP	MF_01022. [Tree]
InterPro	IPR006549. HAD-SF_hydro_IIIA. IPR005954. HisB_N. IPR006543. Histidinol-phos. IPR000807. Imidazole_glycer-P_deHydtase. IPR013954. PNK3P_central-region. [Graphical view]
PANTHER	PTHR23133:SF2. Imidazole-GPD. 1 hit.
Pfam	PF00475. IGPD. 1 hit. PF08645. PNK3P. 1 hit. [Graphical view]
ProDom	PD002282. IGPD. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01662. HAD-SF-IIIA. 1 hit. TIGR01261. hisB_Nterm. 1 hit. TIGR01656. Histidinol-ppas. 1 hit.
PROSITE	PS00954. IGP_DEHYDRATASE_1. 1 hit. PS00955. IGP_DEHYDRATASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS7_SODGM

Accession

Primary (citable) accession number: Q2NTX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 7, 2006
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)