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Q2NTK9

- OTSA_SODGM

UniProt

Q2NTK9 - OTSA_SODGM

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Protein
Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
Gene
otsA, SG1241
Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of glucose from UDP-glucose to glucose-6-phosphate to form alpha,alpha-1,1 trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor By similarity.

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101Glucose-6-phosphate By similarity
Binding sitei77 – 771Glucose-6-phosphate By similarity
Sitei86 – 861Involved in alpha anomer selectivity By similarity
Binding sitei131 – 1311Glucose-6-phosphate By similarity
Sitei156 – 1561Involved in alpha anomer selectivity By similarity
Binding sitei262 – 2621UDP-glucose By similarity
Binding sitei267 – 2671UDP-glucose By similarity
Binding sitei300 – 3001Glucose-6-phosphate By similarity
Binding sitei339 – 3391UDP-glucose; via amide nitrogen and carbonyl oxygen By similarity

GO - Molecular functioni

  1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. trehalose biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciSGLO343509:GJJC-1291-MONOMER.
UniPathwayiUPA00299.

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC:2.4.1.15)
Alternative name(s):
Osmoregulatory trehalose synthesis protein A
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase
Gene namesi
Name:otsA
Ordered Locus Names:SG1241
OrganismiSodalis glossinidius (strain morsitans)
Taxonomic identifieri343509 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis
ProteomesiUP000001932: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
PRO_0000348921Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi343509.SG1241.

Structurei

3D structure databases

ProteinModelPortaliQ2NTK9.
SMRiQ2NTK9. Positions 2-453.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 232UDP-glucose binding By similarity
Regioni365 – 3695UDP-glucose binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0380.
KOiK00697.
OMAiWGESFVK.
OrthoDBiEOG6CCH1M.

Family and domain databases

InterProiIPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02400. trehalose_OtsA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2NTK9-1 [UniParc]FASTAAdd to Basket

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MSRLVVVSNR IAAIEGKKES AGGLAVGIMD SLKDQGGLWF GWNGKISEED    50
EPLEKNQQDN ITFAAFSLKQ SEYDQYYLNF SNTVIWPAFH YRLDLVQYQR 100
EDYDGYCRVN EMLAGRLKPL VNEDDILWIH DYHLLPFAAA CRKLGMKNRI 150
GFFLHIPFPT SEIFNALPPR KELLEKLCEY DLVGFQAESD RQAFIENLAL 200
VTTVEDLDDD RIKAYNKLVT ARVYPIGVEP ESIRELAEGP LPPKLAHLRD 250
KMNGQLIISV DRLDYSKGLP ERFQAYETLL ENYPQHRGNI RYFQIAPTSR 300
GDVQAYQDIR HELETEAGRI NGHFSTLEWT PLFYLNQHYE RSLLMKIFRH 350
CEVGLVTPLR DGMNLVAKEY VASQNPNDPG VLILSHFAGA ANELTSALLV 400
NPYDRDGVAS ALDKALSMPL SERKARYQEM IAVIKQNDIV HWCQSFLDDL 450
KKIPSKAEIV GQAVSGATR 469
Length:469
Mass (Da):53,446
Last modified:February 7, 2006 - v1
Checksum:i9E96324BCDDFDFF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008232 Genomic DNA. Translation: BAE74516.1.
RefSeqiWP_011411070.1. NC_007712.1.
YP_454921.1. NC_007712.1.

Genome annotation databases

EnsemblBacteriaiBAE74516; BAE74516; SG1241.
GeneIDi3866764.
KEGGisgl:SG1241.
PATRICi23651168. VBISodGlo61428_2884.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008232 Genomic DNA. Translation: BAE74516.1 .
RefSeqi WP_011411070.1. NC_007712.1.
YP_454921.1. NC_007712.1.

3D structure databases

ProteinModelPortali Q2NTK9.
SMRi Q2NTK9. Positions 2-453.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 343509.SG1241.

Protein family/group databases

CAZyi GT20. Glycosyltransferase Family 20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE74516 ; BAE74516 ; SG1241 .
GeneIDi 3866764.
KEGGi sgl:SG1241.
PATRICi 23651168. VBISodGlo61428_2884.

Phylogenomic databases

eggNOGi COG0380.
KOi K00697.
OMAi WGESFVK.
OrthoDBi EOG6CCH1M.

Enzyme and pathway databases

UniPathwayi UPA00299 .
BioCyci SGLO343509:GJJC-1291-MONOMER.

Family and domain databases

InterProi IPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view ]
Pfami PF00982. Glyco_transf_20. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02400. trehalose_OtsA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
    Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
    Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: morsitans.

Entry informationi

Entry nameiOTSA_SODGM
AccessioniPrimary (citable) accession number: Q2NTK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: February 7, 2006
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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