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Q2NTK9

- OTSA_SODGM

UniProt

Q2NTK9 - OTSA_SODGM

Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming]

Gene

otsA

Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of glucose from UDP-glucose to glucose-6-phosphate to form alpha,alpha-1,1 trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor By similarity.By similarity

    Catalytic activityi

    UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei10 – 101Glucose-6-phosphateBy similarity
    Binding sitei77 – 771Glucose-6-phosphateBy similarity
    Sitei86 – 861Involved in alpha anomer selectivityBy similarity
    Binding sitei131 – 1311Glucose-6-phosphateBy similarity
    Sitei156 – 1561Involved in alpha anomer selectivityBy similarity
    Binding sitei262 – 2621UDP-glucoseBy similarity
    Binding sitei267 – 2671UDP-glucoseBy similarity
    Binding sitei300 – 3001Glucose-6-phosphateBy similarity
    Binding sitei339 – 3391UDP-glucose; via amide nitrogen and carbonyl oxygenBy similarity

    GO - Molecular functioni

    1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

    GO - Biological processi

    1. trehalose biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciSGLO343509:GJJC-1291-MONOMER.
    UniPathwayiUPA00299.

    Protein family/group databases

    CAZyiGT20. Glycosyltransferase Family 20.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC:2.4.1.15)
    Alternative name(s):
    Osmoregulatory trehalose synthesis protein A
    Trehalose-6-phosphate synthase
    UDP-glucose-glucosephosphate glucosyltransferase
    Gene namesi
    Name:otsA
    Ordered Locus Names:SG1241
    OrganismiSodalis glossinidius (strain morsitans)
    Taxonomic identifieri343509 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis
    ProteomesiUP000001932: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 469469Alpha,alpha-trehalose-phosphate synthase [UDP-forming]PRO_0000348921Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi343509.SG1241.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2NTK9.
    SMRiQ2NTK9. Positions 2-453.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni22 – 232UDP-glucose bindingBy similarity
    Regioni365 – 3695UDP-glucose bindingBy similarity

    Sequence similaritiesi

    Belongs to the glycosyltransferase 20 family.Curated

    Phylogenomic databases

    eggNOGiCOG0380.
    KOiK00697.
    OMAiWGESFVK.
    OrthoDBiEOG6CCH1M.

    Family and domain databases

    InterProiIPR001830. Glyco_trans_20.
    IPR012766. Trehalose_OtsA.
    [Graphical view]
    PfamiPF00982. Glyco_transf_20. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02400. trehalose_OtsA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2NTK9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRLVVVSNR IAAIEGKKES AGGLAVGIMD SLKDQGGLWF GWNGKISEED    50
    EPLEKNQQDN ITFAAFSLKQ SEYDQYYLNF SNTVIWPAFH YRLDLVQYQR 100
    EDYDGYCRVN EMLAGRLKPL VNEDDILWIH DYHLLPFAAA CRKLGMKNRI 150
    GFFLHIPFPT SEIFNALPPR KELLEKLCEY DLVGFQAESD RQAFIENLAL 200
    VTTVEDLDDD RIKAYNKLVT ARVYPIGVEP ESIRELAEGP LPPKLAHLRD 250
    KMNGQLIISV DRLDYSKGLP ERFQAYETLL ENYPQHRGNI RYFQIAPTSR 300
    GDVQAYQDIR HELETEAGRI NGHFSTLEWT PLFYLNQHYE RSLLMKIFRH 350
    CEVGLVTPLR DGMNLVAKEY VASQNPNDPG VLILSHFAGA ANELTSALLV 400
    NPYDRDGVAS ALDKALSMPL SERKARYQEM IAVIKQNDIV HWCQSFLDDL 450
    KKIPSKAEIV GQAVSGATR 469
    Length:469
    Mass (Da):53,446
    Last modified:February 7, 2006 - v1
    Checksum:i9E96324BCDDFDFF6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008232 Genomic DNA. Translation: BAE74516.1.
    RefSeqiWP_011411070.1. NC_007712.1.
    YP_454921.1. NC_007712.1.

    Genome annotation databases

    EnsemblBacteriaiBAE74516; BAE74516; SG1241.
    GeneIDi3866764.
    KEGGisgl:SG1241.
    PATRICi23651168. VBISodGlo61428_2884.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008232 Genomic DNA. Translation: BAE74516.1 .
    RefSeqi WP_011411070.1. NC_007712.1.
    YP_454921.1. NC_007712.1.

    3D structure databases

    ProteinModelPortali Q2NTK9.
    SMRi Q2NTK9. Positions 2-453.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 343509.SG1241.

    Protein family/group databases

    CAZyi GT20. Glycosyltransferase Family 20.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE74516 ; BAE74516 ; SG1241 .
    GeneIDi 3866764.
    KEGGi sgl:SG1241.
    PATRICi 23651168. VBISodGlo61428_2884.

    Phylogenomic databases

    eggNOGi COG0380.
    KOi K00697.
    OMAi WGESFVK.
    OrthoDBi EOG6CCH1M.

    Enzyme and pathway databases

    UniPathwayi UPA00299 .
    BioCyci SGLO343509:GJJC-1291-MONOMER.

    Family and domain databases

    InterProi IPR001830. Glyco_trans_20.
    IPR012766. Trehalose_OtsA.
    [Graphical view ]
    Pfami PF00982. Glyco_transf_20. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02400. trehalose_OtsA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
      Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
      Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: morsitans.

    Entry informationi

    Entry nameiOTSA_SODGM
    AccessioniPrimary (citable) accession number: Q2NTK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3