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Q2NTA8 (ALR_SODGM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alanine racemase
EC=5.1.1.1
Gene names
Name:alr
Ordered Locus Names:SG1342
OrganismSodalis glossinidius (strain morsitans) [Complete proteome] [HAMAP]
Taxonomic identifier343509 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Sodalis ›

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-alanine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

peptidoglycan biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

regulation of cell shape

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionalanine racemase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356Alanine racemase HAMAP-Rule MF_01201
PRO_1000066039

Sites

Active site351Proton acceptor; specific for D-alanine By similarity
Active site2531Proton acceptor; specific for L-alanine By similarity
Binding site1301Substrate By similarity
Binding site3011Substrate; via amide nitrogen By similarity

Amino acid modifications

Modified residue351N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2NTA8 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 3484A08AAB98067E

FASTA35638,378
        10         20         30         40         50         60 
MPRPIVAKVD SAVLASNLSI VRRHAPQAQV WSVVKANGYG HGLNTVWQGL QQTDGFALLD 

        70         80         90        100        110        120 
LHEAVVLREK GWRGPILLLE GFFQPADLAV IDRYRLTTVV HSDWQIEALR RMTPRAPLDI 

       130        140        150        160        170        180 
YLKLNSGMNR LGFSERALPG AWQSLNALKH VATLTLMSHF AYADMPEGVE GQMAVVARAG 

       190        200        210        220        230        240 
EGLTGPRCLA NSAATLWHPA THGQWVRPGI ILYGASPSGN WQDIAASGLR PVMTLQSELI 

       250        260        270        280        290        300 
AVQSVPAGGR IGYGGRHRVS ETHRVGVVAC GYADGYPRHA PTGTPILVDG VRTSTLGAVS 

       310        320        330        340        350 
MDMLMVDLQL CPKARIGSAV ELWGDHVKID EVAASAGTLG YELMSALAPR VTVQIR

« Hide

References

[1]"Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: morsitans.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008232 Genomic DNA. Translation: BAE74617.1.
RefSeqYP_455022.1. NC_007712.1.

3D structure databases

HSSPHSSP built from PDB template 1FTX based on UniProtKB P10724.
ProteinModelPortalQ2NTA8.
ModBaseSearch...

Protein-protein interaction databases

STRING343509.SG1342.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE74617; BAE74617; ENAG00095886.
GeneID3866413.
KEGGsgl:SG1342.
PATRIC23651545. VBISodGlo61428_3071.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000076274.
KOK01775.
OMAGQWQDIA.

Enzyme and pathway databases

BioCycSGLO343509:GJJC-1393-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR_SODGM
AccessionPrimary (citable) accession number: Q2NTA8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 7, 2006
Last modified: May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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