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Q2NT36

- PYRF_SODGM

UniProt

Q2NT36 - PYRF_SODGM

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei26 – 261SubstrateUniRule annotation
Binding sitei48 – 481SubstrateUniRule annotation
Active sitei77 – 771Proton donorUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Binding sitei196 – 1961SubstrateUniRule annotation
Binding sitei205 – 2051SubstrateUniRule annotation
Binding sitei225 – 2251Substrate; via amide nitrogenUniRule annotation
Binding sitei226 – 2261SubstrateUniRule annotation

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciSGLO343509:GJJC-1466-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:SG1414
OrganismiSodalis glossinidius (strain morsitans)
Taxonomic identifieri343509 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis
ProteomesiUP000001932: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Orotidine 5'-phosphate decarboxylasePRO_0000241909Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi343509.SG1414.

Structurei

3D structure databases

ProteinModelPortaliQ2NT36.
SMRiQ2NT36. Positions 19-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni75 – 8410Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0284.
KOiK01591.
OMAiRPITQSA.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2NT36 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRTILSSSS SLSPQQAGSP VIVALDYADA RQALAFADRV APSQCRLKIG
60 70 80 90 100
KEMFTQAGPA LVRDLQQRGF EVFLDLKFHD IPNTVAKAVS AAAELGVWMV
110 120 130 140 150
NVHASGGERM MAAAREALVP FGADAPVLIA VTVLTSMNDE DLRGIGIAGS
160 170 180 190 200
ASDHAVRLAI LAQACGLDGV VCSAWEAARL KTDCGAGFAL VTPGIRPTGS
210 220 230 240 250
DAGDQRRVMT PLQAQQVGVD YMVIGRPITQ AADPAATLAA ILQELQPGGA

DV
Length:252
Mass (Da):26,192
Last modified:February 7, 2006 - v1
Checksum:iAA8CB100D6823F10
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008232 Genomic DNA. Translation: BAE74689.1.
RefSeqiWP_011411234.1. NC_007712.1.
YP_455094.1. NC_007712.1.

Genome annotation databases

EnsemblBacteriaiBAE74689; BAE74689; SG1414.
GeneIDi3866975.
KEGGisgl:SG1414.
PATRICi23651845. VBISodGlo61428_3219.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008232 Genomic DNA. Translation: BAE74689.1 .
RefSeqi WP_011411234.1. NC_007712.1.
YP_455094.1. NC_007712.1.

3D structure databases

ProteinModelPortali Q2NT36.
SMRi Q2NT36. Positions 19-246.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 343509.SG1414.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE74689 ; BAE74689 ; SG1414 .
GeneIDi 3866975.
KEGGi sgl:SG1414.
PATRICi 23651845. VBISodGlo61428_3219.

Phylogenomic databases

eggNOGi COG0284.
KOi K01591.
OMAi RPITQSA.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci SGLO343509:GJJC-1466-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
    Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
    Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: morsitans.

Entry informationi

Entry nameiPYRF_SODGM
AccessioniPrimary (citable) accession number: Q2NT36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: February 7, 2006
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3