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Q2NRV8

- ARND_SODGM

UniProt

Q2NRV8 - ARND_SODGM

Protein

Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD

Gene

arnD

Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

    Catalytic activityi

    4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process Source: UniProtKB-UniPathway
    2. lipid A biosynthetic process Source: UniProtKB-HAMAP
    3. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
    4. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    BioCyciSGLO343509:GJJC-1904-MONOMER.
    UniPathwayiUPA00030.
    UPA00036; UER00496.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDUniRule annotation (EC:3.5.1.n3UniRule annotation)
    Gene namesi
    Name:arnDUniRule annotation
    Ordered Locus Names:SG1842
    OrganismiSodalis glossinidius (strain morsitans)
    Taxonomic identifieri343509 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis
    ProteomesiUP000001932: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 297297Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDPRO_0000383548Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi343509.SG1842.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2NRV8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 260259NodB homologyUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.UniRule annotation
    Contains 1 NodB homology domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0726.
    HOGENOMiHOG000261199.
    KOiK13014.
    OMAiLHAWDHF.
    OrthoDBiEOG6423D0.

    Family and domain databases

    Gene3Di3.20.20.370. 2 hits.
    HAMAPiMF_01870. ArnD.
    InterProiIPR023557. ArnD.
    IPR011330. Glyco_hydro/deAcase_b/a-brl.
    IPR002509. Polysac_deacetylase.
    [Graphical view]
    PfamiPF01522. Polysacc_deac_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF88713. SSF88713. 2 hits.
    PROSITEiPS51677. NODB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2NRV8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNVGLRIDV DTWRGTRDGM PRLLELLAAQ QIQATFFFSV GPDNMGRHLW    50
    RLAKPQFLLK MLRSRAASLY GWDILLAGTA WPGRKIGQGL AAQIRAAAAD 100
    HEVGLHAWDH FAWQTWAGVW SERQLTEQIR LARDALTAII ERPVTCSAVA 150
    GWRADDRVVQ AKQPFDFHYN SDCRGTEPFR PLLANGAFGA VQIPVTQPTF 200
    DEAIGQTTTR AGYNHFILDS IKADRGTPVY TIHAEVEGIA LSGMFQELLS 250
    MAVAEGIRFC PLRELLPQDT AALPVGQVVR GEIPGREGWV GCQRLLK 297
    Length:297
    Mass (Da):32,982
    Last modified:February 7, 2006 - v1
    Checksum:i07A6838B6AED84ED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008232 Genomic DNA. Translation: BAE75117.1.
    RefSeqiYP_455522.1. NC_007712.1.

    Genome annotation databases

    EnsemblBacteriaiBAE75117; BAE75117; SG1842.
    GeneIDi3868635.
    KEGGisgl:SG1842.
    PATRICi23654177. VBISodGlo61428_4377.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008232 Genomic DNA. Translation: BAE75117.1 .
    RefSeqi YP_455522.1. NC_007712.1.

    3D structure databases

    ProteinModelPortali Q2NRV8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 343509.SG1842.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE75117 ; BAE75117 ; SG1842 .
    GeneIDi 3868635.
    KEGGi sgl:SG1842.
    PATRICi 23654177. VBISodGlo61428_4377.

    Phylogenomic databases

    eggNOGi COG0726.
    HOGENOMi HOG000261199.
    KOi K13014.
    OMAi LHAWDHF.
    OrthoDBi EOG6423D0.

    Enzyme and pathway databases

    UniPathwayi UPA00030 .
    UPA00036 ; UER00496 .
    BioCyci SGLO343509:GJJC-1904-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.370. 2 hits.
    HAMAPi MF_01870. ArnD.
    InterProi IPR023557. ArnD.
    IPR011330. Glyco_hydro/deAcase_b/a-brl.
    IPR002509. Polysac_deacetylase.
    [Graphical view ]
    Pfami PF01522. Polysacc_deac_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF88713. SSF88713. 2 hits.
    PROSITEi PS51677. NODB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
      Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
      Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: morsitans.

    Entry informationi

    Entry nameiARND_SODGM
    AccessioniPrimary (citable) accession number: Q2NRV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3