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Q2NRM0

- LPXB_SODGM

UniProt

Q2NRM0 - LPXB_SODGM

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSGLO343509:GJJC-1996-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:SG1930
OrganismiSodalis glossinidius (strain morsitans)
Taxonomic identifieri343509 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis
ProteomesiUP000001932: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Lipid-A-disaccharide synthasePRO_0000255227Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi343509.SG1930.

Structurei

3D structure databases

ProteinModelPortaliQ2NRM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
KOiK00748.
OMAiEWTINPP.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2NRM0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSARPITIGL VAGETSGDIL GAGLIRALRG HLPEARFVGV AGPRMQAEGM
60 70 80 90 100
EAWYDMEELA VMGIVEVVER LPRLLRIRRD LTRRFTALRP DVFVGIDAPD
110 120 130 140 150
FTITLEGRLK RRGIRTIHYV SPSVWAWRQK RVFKIGRATD NVLAFLPFEK
160 170 180 190 200
AFYDCYNVPC QFIGHTLADA MSLDPDKAAA RQALGIAAEA RCLALLPGSR
210 220 230 240 250
QSEVAMLSAD FLRAAERLYE CFPGLEIVVP LVNPARRAQF EHILVAVAPA
260 270 280 290 300
LPVRLLDNQA RQAMIAADAA LLASGTASLE CMLAKCPMVV GYRMKPLTFA
310 320 330 340 350
LARRLVKTPW VSLPNLLAGR ELVKELLQEA CQPEALAAAL EPLLDDDDQR
360 370 380
AALLAMFRQL HQQIRCNADE QAARAVLALI NR
Length:382
Mass (Da):42,150
Last modified:February 7, 2006 - v1
Checksum:i3F6D7739C84698F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008232 Genomic DNA. Translation: BAE75205.1.
RefSeqiYP_455610.1. NC_007712.1.

Genome annotation databases

EnsemblBacteriaiBAE75205; BAE75205; SG1930.
GeneIDi3867842.
KEGGisgl:SG1930.
PATRICi23654811. VBISodGlo61428_4690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008232 Genomic DNA. Translation: BAE75205.1 .
RefSeqi YP_455610.1. NC_007712.1.

3D structure databases

ProteinModelPortali Q2NRM0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 343509.SG1930.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE75205 ; BAE75205 ; SG1930 .
GeneIDi 3867842.
KEGGi sgl:SG1930.
PATRICi 23654811. VBISodGlo61428_4690.

Phylogenomic databases

eggNOGi COG0763.
KOi K00748.
OMAi EWTINPP.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci SGLO343509:GJJC-1996-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
    Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
    Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: morsitans.

Entry informationi

Entry nameiLPXB_SODGM
AccessioniPrimary (citable) accession number: Q2NRM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 7, 2006
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3