Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q2NRF0

- GCSP_SODGM

UniProt

Q2NRF0 - GCSP_SODGM

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSGLO343509:GJJC-2069-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:SG2000
OrganismiSodalis glossinidius (strain morsitans)
Taxonomic identifieri343509 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis
ProteomesiUP000001932: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 953953Glycine dehydrogenase (decarboxylating)PRO_1000045621Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei705 – 7051N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi343509.SG2000.

Structurei

3D structure databases

ProteinModelPortaliQ2NRF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2NRF0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQTLSQLEH HDAFIARHIG PSAPQQVHML ATVGSDSLAG LIAQIVPADI
60 70 80 90 100
QLAAAPAVGE ATTEAQALAE LKAIARQNQR YKSFIGMGYS AVVTPPVILR
110 120 130 140 150
NMLENPGWYT AYTPYQPEVS QGRLEALLNF QQLTLDLTGL DIASASLLDE
160 170 180 190 200
ATAAAEAMAL AKRSSKLKQA NCFFVADDVH PQTLDVLRTR AGTFGFELVI
210 220 230 240 250
DKAQAALEHP DLFGVLLQQV GTTGELHDYR ALMAELTRRK IISCVAADML
260 270 280 290 300
SLVLLAAPGE QGADVVFGSS QRFGVPMGYG GPHAAFFAAR DEMKRAMPGR
310 320 330 340 350
IIGVSRDAAG DTALRMVMQT REQHIRREKA NSNICTSQVL LANIAGLYAV
360 370 380 390 400
YHGPQGLKRI AGRIHRLTTI LAQGLHDADL TLRHDRWFDT LTVEVVDKAG
410 420 430 440 450
VLARANAAGI NLRSDIHGAV GITLDETTVR EDVQTLWQVV TGAAGTLAID
460 470 480 490 500
ALDAGCDEVI PPELLRATPI LTHEVFNRYH SETEMMRYMH RLERKDLALN
510 520 530 540 550
QAMIPLGSCT MKLNAAAEMI PITWPEFAEL HPFCPPEQAA GYQQMIAQLS
560 570 580 590 600
RWLIQLTGYD ALCMQPNSGA QGEYAGLLAI RRYHESRNQG ERHICLIPSS
610 620 630 640 650
AHGTNPASAQ MAGMSVTVVA CDKNGNIDLH DLRAKAEQAG EQLSCIMVTY
660 670 680 690 700
PSTHGVYEET IREVCQIVHQ YGGQVYLDGA NMNAQVGITS PGYIGADVSH
710 720 730 740 750
LNLHKTFCIP HGGGGPGMGP IGVKAHLAPF VPGHLVVELD GVLTRQGAVS
760 770 780 790 800
AAPFGSASIL PISWMYIRMM GAEGLKQASQ VAILNANYIA TRLQQAYPVL
810 820 830 840 850
YTGRAGRVAH ECILDIRPLK EATGISEMDI AKRLIDYGFH APTMSFPVAG
860 870 880 890 900
TLMVEPTESE SQLELDRFID AMLAIRAEIQ QVADGVWPAS DNPLVNAPYT
910 920 930 940 950
QRELAGEWRH PYDRQIAAFP AGYGDKYWPA VKRLDDVYGD RNLFCACVPL

SDY
Length:953
Mass (Da):103,555
Last modified:February 7, 2006 - v1
Checksum:i836B7A91EA51DFA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008232 Genomic DNA. Translation: BAE75275.1.
RefSeqiWP_011411730.1. NC_007712.1.
YP_455680.1. NC_007712.1.

Genome annotation databases

EnsemblBacteriaiBAE75275; BAE75275; SG2000.
GeneIDi3867081.
KEGGisgl:SG2000.
PATRICi23655134. VBISodGlo61428_4848.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008232 Genomic DNA. Translation: BAE75275.1 .
RefSeqi WP_011411730.1. NC_007712.1.
YP_455680.1. NC_007712.1.

3D structure databases

ProteinModelPortali Q2NRF0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 343509.SG2000.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE75275 ; BAE75275 ; SG2000 .
GeneIDi 3867081.
KEGGi sgl:SG2000.
PATRICi 23655134. VBISodGlo61428_4848.

Phylogenomic databases

eggNOGi COG1003.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SGLO343509:GJJC-2069-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
    Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
    Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: morsitans.

Entry informationi

Entry nameiGCSP_SODGM
AccessioniPrimary (citable) accession number: Q2NRF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: November 26, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3