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Q2NRF0 (GCSP_SODGM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:SG2000
OrganismSodalis glossinidius (strain morsitans) [Complete proteome] [HAMAP]
Taxonomic identifier343509 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis

Protein attributes

Sequence length953 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 953953Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045621

Amino acid modifications

Modified residue7051N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2NRF0 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 836B7A91EA51DFA2

FASTA953103,555
        10         20         30         40         50         60 
MTQTLSQLEH HDAFIARHIG PSAPQQVHML ATVGSDSLAG LIAQIVPADI QLAAAPAVGE 

        70         80         90        100        110        120 
ATTEAQALAE LKAIARQNQR YKSFIGMGYS AVVTPPVILR NMLENPGWYT AYTPYQPEVS 

       130        140        150        160        170        180 
QGRLEALLNF QQLTLDLTGL DIASASLLDE ATAAAEAMAL AKRSSKLKQA NCFFVADDVH 

       190        200        210        220        230        240 
PQTLDVLRTR AGTFGFELVI DKAQAALEHP DLFGVLLQQV GTTGELHDYR ALMAELTRRK 

       250        260        270        280        290        300 
IISCVAADML SLVLLAAPGE QGADVVFGSS QRFGVPMGYG GPHAAFFAAR DEMKRAMPGR 

       310        320        330        340        350        360 
IIGVSRDAAG DTALRMVMQT REQHIRREKA NSNICTSQVL LANIAGLYAV YHGPQGLKRI 

       370        380        390        400        410        420 
AGRIHRLTTI LAQGLHDADL TLRHDRWFDT LTVEVVDKAG VLARANAAGI NLRSDIHGAV 

       430        440        450        460        470        480 
GITLDETTVR EDVQTLWQVV TGAAGTLAID ALDAGCDEVI PPELLRATPI LTHEVFNRYH 

       490        500        510        520        530        540 
SETEMMRYMH RLERKDLALN QAMIPLGSCT MKLNAAAEMI PITWPEFAEL HPFCPPEQAA 

       550        560        570        580        590        600 
GYQQMIAQLS RWLIQLTGYD ALCMQPNSGA QGEYAGLLAI RRYHESRNQG ERHICLIPSS 

       610        620        630        640        650        660 
AHGTNPASAQ MAGMSVTVVA CDKNGNIDLH DLRAKAEQAG EQLSCIMVTY PSTHGVYEET 

       670        680        690        700        710        720 
IREVCQIVHQ YGGQVYLDGA NMNAQVGITS PGYIGADVSH LNLHKTFCIP HGGGGPGMGP 

       730        740        750        760        770        780 
IGVKAHLAPF VPGHLVVELD GVLTRQGAVS AAPFGSASIL PISWMYIRMM GAEGLKQASQ 

       790        800        810        820        830        840 
VAILNANYIA TRLQQAYPVL YTGRAGRVAH ECILDIRPLK EATGISEMDI AKRLIDYGFH 

       850        860        870        880        890        900 
APTMSFPVAG TLMVEPTESE SQLELDRFID AMLAIRAEIQ QVADGVWPAS DNPLVNAPYT 

       910        920        930        940        950 
QRELAGEWRH PYDRQIAAFP AGYGDKYWPA VKRLDDVYGD RNLFCACVPL SDY 

« Hide

References

[1]"Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: morsitans.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008232 Genomic DNA. Translation: BAE75275.1.
RefSeqYP_455680.1. NC_007712.1.

3D structure databases

ProteinModelPortalQ2NRF0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING343509.SG2000.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE75275; BAE75275; SG2000.
GeneID3867081.
KEGGsgl:SG2000.
PATRIC23655134. VBISodGlo61428_4848.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycSGLO343509:GJJC-2069-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_SODGM
AccessionPrimary (citable) accession number: Q2NRF0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families