Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:SG2000
OrganismiSodalis glossinidius (strain morsitans)
Taxonomic identifieri343509 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaeSodalis
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000456211 – 953Glycine dehydrogenase (decarboxylating)Add BLAST953

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei705N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ2NRF0

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi343509.SG2000

Structurei

3D structure databases

ProteinModelPortaliQ2NRF0
SMRiQ2NRF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
KOiK00281
OMAiQTMVCDL
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

Q2NRF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQTLSQLEH HDAFIARHIG PSAPQQVHML ATVGSDSLAG LIAQIVPADI
60 70 80 90 100
QLAAAPAVGE ATTEAQALAE LKAIARQNQR YKSFIGMGYS AVVTPPVILR
110 120 130 140 150
NMLENPGWYT AYTPYQPEVS QGRLEALLNF QQLTLDLTGL DIASASLLDE
160 170 180 190 200
ATAAAEAMAL AKRSSKLKQA NCFFVADDVH PQTLDVLRTR AGTFGFELVI
210 220 230 240 250
DKAQAALEHP DLFGVLLQQV GTTGELHDYR ALMAELTRRK IISCVAADML
260 270 280 290 300
SLVLLAAPGE QGADVVFGSS QRFGVPMGYG GPHAAFFAAR DEMKRAMPGR
310 320 330 340 350
IIGVSRDAAG DTALRMVMQT REQHIRREKA NSNICTSQVL LANIAGLYAV
360 370 380 390 400
YHGPQGLKRI AGRIHRLTTI LAQGLHDADL TLRHDRWFDT LTVEVVDKAG
410 420 430 440 450
VLARANAAGI NLRSDIHGAV GITLDETTVR EDVQTLWQVV TGAAGTLAID
460 470 480 490 500
ALDAGCDEVI PPELLRATPI LTHEVFNRYH SETEMMRYMH RLERKDLALN
510 520 530 540 550
QAMIPLGSCT MKLNAAAEMI PITWPEFAEL HPFCPPEQAA GYQQMIAQLS
560 570 580 590 600
RWLIQLTGYD ALCMQPNSGA QGEYAGLLAI RRYHESRNQG ERHICLIPSS
610 620 630 640 650
AHGTNPASAQ MAGMSVTVVA CDKNGNIDLH DLRAKAEQAG EQLSCIMVTY
660 670 680 690 700
PSTHGVYEET IREVCQIVHQ YGGQVYLDGA NMNAQVGITS PGYIGADVSH
710 720 730 740 750
LNLHKTFCIP HGGGGPGMGP IGVKAHLAPF VPGHLVVELD GVLTRQGAVS
760 770 780 790 800
AAPFGSASIL PISWMYIRMM GAEGLKQASQ VAILNANYIA TRLQQAYPVL
810 820 830 840 850
YTGRAGRVAH ECILDIRPLK EATGISEMDI AKRLIDYGFH APTMSFPVAG
860 870 880 890 900
TLMVEPTESE SQLELDRFID AMLAIRAEIQ QVADGVWPAS DNPLVNAPYT
910 920 930 940 950
QRELAGEWRH PYDRQIAAFP AGYGDKYWPA VKRLDDVYGD RNLFCACVPL

SDY
Length:953
Mass (Da):103,555
Last modified:February 7, 2006 - v1
Checksum:i836B7A91EA51DFA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008232 Genomic DNA Translation: BAE75275.1
RefSeqiWP_011411730.1, NC_007712.1

Genome annotation databases

EnsemblBacteriaiBAE75275; BAE75275; SG2000
KEGGisgl:SG2000

Similar proteinsi

Entry informationi

Entry nameiGCSP_SODGM
AccessioniPrimary (citable) accession number: Q2NRF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health