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Q2NRF0

- GCSP_SODGM

UniProt

Q2NRF0 - GCSP_SODGM

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, SG2000
Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSGLO343509:GJJC-2069-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:SG2000
OrganismiSodalis glossinidius (strain morsitans)
Taxonomic identifieri343509 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis
ProteomesiUP000001932: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 953953Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000045621Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei705 – 7051N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi343509.SG2000.

Structurei

3D structure databases

ProteinModelPortaliQ2NRF0.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2NRF0-1 [UniParc]FASTAAdd to Basket

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MTQTLSQLEH HDAFIARHIG PSAPQQVHML ATVGSDSLAG LIAQIVPADI    50
QLAAAPAVGE ATTEAQALAE LKAIARQNQR YKSFIGMGYS AVVTPPVILR 100
NMLENPGWYT AYTPYQPEVS QGRLEALLNF QQLTLDLTGL DIASASLLDE 150
ATAAAEAMAL AKRSSKLKQA NCFFVADDVH PQTLDVLRTR AGTFGFELVI 200
DKAQAALEHP DLFGVLLQQV GTTGELHDYR ALMAELTRRK IISCVAADML 250
SLVLLAAPGE QGADVVFGSS QRFGVPMGYG GPHAAFFAAR DEMKRAMPGR 300
IIGVSRDAAG DTALRMVMQT REQHIRREKA NSNICTSQVL LANIAGLYAV 350
YHGPQGLKRI AGRIHRLTTI LAQGLHDADL TLRHDRWFDT LTVEVVDKAG 400
VLARANAAGI NLRSDIHGAV GITLDETTVR EDVQTLWQVV TGAAGTLAID 450
ALDAGCDEVI PPELLRATPI LTHEVFNRYH SETEMMRYMH RLERKDLALN 500
QAMIPLGSCT MKLNAAAEMI PITWPEFAEL HPFCPPEQAA GYQQMIAQLS 550
RWLIQLTGYD ALCMQPNSGA QGEYAGLLAI RRYHESRNQG ERHICLIPSS 600
AHGTNPASAQ MAGMSVTVVA CDKNGNIDLH DLRAKAEQAG EQLSCIMVTY 650
PSTHGVYEET IREVCQIVHQ YGGQVYLDGA NMNAQVGITS PGYIGADVSH 700
LNLHKTFCIP HGGGGPGMGP IGVKAHLAPF VPGHLVVELD GVLTRQGAVS 750
AAPFGSASIL PISWMYIRMM GAEGLKQASQ VAILNANYIA TRLQQAYPVL 800
YTGRAGRVAH ECILDIRPLK EATGISEMDI AKRLIDYGFH APTMSFPVAG 850
TLMVEPTESE SQLELDRFID AMLAIRAEIQ QVADGVWPAS DNPLVNAPYT 900
QRELAGEWRH PYDRQIAAFP AGYGDKYWPA VKRLDDVYGD RNLFCACVPL 950
SDY 953
Length:953
Mass (Da):103,555
Last modified:February 7, 2006 - v1
Checksum:i836B7A91EA51DFA2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008232 Genomic DNA. Translation: BAE75275.1.
RefSeqiYP_455680.1. NC_007712.1.

Genome annotation databases

EnsemblBacteriaiBAE75275; BAE75275; SG2000.
GeneIDi3867081.
KEGGisgl:SG2000.
PATRICi23655134. VBISodGlo61428_4848.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008232 Genomic DNA. Translation: BAE75275.1 .
RefSeqi YP_455680.1. NC_007712.1.

3D structure databases

ProteinModelPortali Q2NRF0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 343509.SG2000.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE75275 ; BAE75275 ; SG2000 .
GeneIDi 3867081.
KEGGi sgl:SG2000.
PATRICi 23655134. VBISodGlo61428_4848.

Phylogenomic databases

eggNOGi COG1003.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SGLO343509:GJJC-2069-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
    Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
    Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: morsitans.

Entry informationi

Entry nameiGCSP_SODGM
AccessioniPrimary (citable) accession number: Q2NRF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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