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Q2NRD3

- SPEB_SODGM

UniProt

Q2NRD3 - SPEB_SODGM

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Protein

Agmatinase

Gene

speB

Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of putrescine from agmatine.UniRule annotation

Catalytic activityi

Agmatine + H2O = putrescine + urea.UniRule annotation

Cofactori

Manganese.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi126 – 1261ManganeseUniRule annotation
Metal bindingi149 – 1491ManganeseUniRule annotation
Metal bindingi151 – 1511ManganeseUniRule annotation
Metal bindingi153 – 1531ManganeseUniRule annotation
Metal bindingi230 – 2301ManganeseUniRule annotation
Metal bindingi232 – 2321ManganeseUniRule annotation

GO - Molecular functioni

  1. agmatinase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: InterPro

GO - Biological processi

  1. putrescine biosynthetic process from arginine Source: UniProtKB-UniPathway
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSGLO343509:GJJC-2086-MONOMER.
UniPathwayiUPA00534; UER00287.

Names & Taxonomyi

Protein namesi
Recommended name:
AgmatinaseUniRule annotation (EC:3.5.3.11UniRule annotation)
Alternative name(s):
Agmatine ureohydrolaseUniRule annotation
Short name:
AUHUniRule annotation
Gene namesi
Name:speBUniRule annotation
Ordered Locus Names:SG2017
OrganismiSodalis glossinidius (strain morsitans)
Taxonomic identifieri343509 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis
ProteomesiUP000001932: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307AgmatinasePRO_1000024288Add
BLAST

Proteomic databases

PRIDEiQ2NRD3.

Interactioni

Protein-protein interaction databases

STRINGi343509.SG2017.

Structurei

3D structure databases

ProteinModelPortaliQ2NRD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family. Agmatinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0010.
KOiK01480.
OMAiKPDYSLY.
OrthoDBiEOG6R2GW5.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
HAMAPiMF_01418. SpeB.
InterProiIPR023694. Agmatinase.
IPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
TIGRFAMsiTIGR01230. agmatinase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2NRD3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTLGHNYDN SLVSNAFGFL RLPLEFNPYA TDADWVITGI PFDMATSGRA
60 70 80 90 100
GCRHGPAAIR QVSTNLAWEG CRWPWDFDVR KRLKVVDCGD LVYEFGDAQD
110 120 130 140 150
FCDKLQDHAE RLLAAGKRML SFGGDHFVTL PLLCAHAKHF GKMALVHFDA
160 170 180 190 200
HTDTYANGSK FDHGSMFYHA PNEGLISPAH SVQIGIRTEF ERDNGFTVLD
210 220 230 240 250
AGQVNDRSVD DILAQVKQIV GNLPVYLTFD IDCLDPSAAP GTGTPVIGGL
260 270 280 290 300
TSDRALKLVR GLQPLNIVGM DIVEVAPAYD QAQITALVAA TLALEMLYIQ

GAKRGDD
Length:307
Mass (Da):33,526
Last modified:February 7, 2006 - v1
Checksum:i709F31E00C181ED5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008232 Genomic DNA. Translation: BAE75292.1.
RefSeqiYP_455697.1. NC_007712.1.

Genome annotation databases

EnsemblBacteriaiBAE75292; BAE75292; SG2017.
GeneIDi3868796.
KEGGisgl:SG2017.
PATRICi23655176. VBISodGlo61428_4869.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008232 Genomic DNA. Translation: BAE75292.1 .
RefSeqi YP_455697.1. NC_007712.1.

3D structure databases

ProteinModelPortali Q2NRD3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 343509.SG2017.

Proteomic databases

PRIDEi Q2NRD3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE75292 ; BAE75292 ; SG2017 .
GeneIDi 3868796.
KEGGi sgl:SG2017.
PATRICi 23655176. VBISodGlo61428_4869.

Phylogenomic databases

eggNOGi COG0010.
KOi K01480.
OMAi KPDYSLY.
OrthoDBi EOG6R2GW5.

Enzyme and pathway databases

UniPathwayi UPA00534 ; UER00287 .
BioCyci SGLO343509:GJJC-2086-MONOMER.

Family and domain databases

Gene3Di 3.40.800.10. 1 hit.
HAMAPi MF_01418. SpeB.
InterProi IPR023694. Agmatinase.
IPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view ]
PANTHERi PTHR11358. PTHR11358. 1 hit.
Pfami PF00491. Arginase. 1 hit.
[Graphical view ]
PIRSFi PIRSF036979. Arginase. 1 hit.
TIGRFAMsi TIGR01230. agmatinase. 1 hit.
PROSITEi PS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
    Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
    Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: morsitans.

Entry informationi

Entry nameiSPEB_SODGM
AccessioniPrimary (citable) accession number: Q2NRD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: October 1, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3