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Protein

Agmatinase

Gene

speB

Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of putrescine from agmatine.UniRule annotation

Catalytic activityi

Agmatine + H2O = putrescine + urea.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi: putrescine biosynthesis via agmatine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from agmatine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Agmatinase (speB), Agmatinase (speB)
This subpathway is part of the pathway putrescine biosynthesis via agmatine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from agmatine, the pathway putrescine biosynthesis via agmatine pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi126ManganeseUniRule annotation1
Metal bindingi149ManganeseUniRule annotation1
Metal bindingi151ManganeseUniRule annotation1
Metal bindingi153ManganeseUniRule annotation1
Metal bindingi230ManganeseUniRule annotation1
Metal bindingi232ManganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPolyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciSGLO343509:G1G2G-3841-MONOMER
UniPathwayiUPA00534; UER00287

Names & Taxonomyi

Protein namesi
Recommended name:
AgmatinaseUniRule annotation (EC:3.5.3.11UniRule annotation)
Alternative name(s):
Agmatine ureohydrolaseUniRule annotation
Short name:
AUHUniRule annotation
Gene namesi
Name:speBUniRule annotation
Ordered Locus Names:SG2017
OrganismiSodalis glossinidius (strain morsitans)
Taxonomic identifieri343509 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaeSodalis
Proteomesi
  • UP000001932 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000242881 – 307AgmatinaseAdd BLAST307

Proteomic databases

PRIDEiQ2NRD3

Interactioni

Protein-protein interaction databases

STRINGi343509.SG2017

Structurei

3D structure databases

ProteinModelPortaliQ2NRD3
SMRiQ2NRD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family. Agmatinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CYW Bacteria
COG0010 LUCA
KOiK01480
OMAiDTYFGAE
OrthoDBiPOG091H0384

Family and domain databases

HAMAPiMF_01418 SpeB, 1 hit
InterProiView protein in InterPro
IPR023694 Agmatinase
IPR005925 Agmatinase-rel
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
IPR020855 Ureohydrolase_Mn_BS
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PIRSFiPIRSF036979 Arginase, 1 hit
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01230 agmatinase, 1 hit
PROSITEiView protein in PROSITE
PS01053 ARGINASE_1, 1 hit
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2NRD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTLGHNYDN SLVSNAFGFL RLPLEFNPYA TDADWVITGI PFDMATSGRA
60 70 80 90 100
GCRHGPAAIR QVSTNLAWEG CRWPWDFDVR KRLKVVDCGD LVYEFGDAQD
110 120 130 140 150
FCDKLQDHAE RLLAAGKRML SFGGDHFVTL PLLCAHAKHF GKMALVHFDA
160 170 180 190 200
HTDTYANGSK FDHGSMFYHA PNEGLISPAH SVQIGIRTEF ERDNGFTVLD
210 220 230 240 250
AGQVNDRSVD DILAQVKQIV GNLPVYLTFD IDCLDPSAAP GTGTPVIGGL
260 270 280 290 300
TSDRALKLVR GLQPLNIVGM DIVEVAPAYD QAQITALVAA TLALEMLYIQ

GAKRGDD
Length:307
Mass (Da):33,526
Last modified:February 7, 2006 - v1
Checksum:i709F31E00C181ED5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008232 Genomic DNA Translation: BAE75292.1
RefSeqiWP_011411747.1, NC_007712.1

Genome annotation databases

EnsemblBacteriaiBAE75292; BAE75292; SG2017
KEGGisgl:SG2017

Similar proteinsi

Entry informationi

Entry nameiSPEB_SODGM
AccessioniPrimary (citable) accession number: Q2NRD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health