Reviewed, UniProtKB/Swiss-Prot Q2NRD3 (SPEB_SODGM)

Names and origin

Protein names

Recommended name:
    Agmatinase
    EC=3.5.3.11
Alternative name(s):
    Agmatine ureohydrolase
      Short name=AUH

Gene names

Name:	speB
Ordered Locus Names:	SG2017

Organism

Sodalis glossinidius (strain morsitans) [Complete proteome] [HAMAP]

Taxonomic identifier

343509 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Sodalis

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the formation of putrescine from agmatine By similarity.
Catalytic activity	Agmatine + H2O = putrescine + urea. HAMAP MF_01418
Cofactor	Manganese By similarity.
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1. HAMAP MF_01418
Sequence similarities	Belongs to the arginase family. Agmatinase subfamily.

Ontologies

Keywords
Biological process	Polyamine biosynthesis Putrescine biosynthesis Spermidine biosynthesis
Ligand	Manganese Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	putrescine biosynthetic process Inferred from electronic annotation. Source: HAMAP spermidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	agmatinase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Agmatinase HAMAP MF_01418		PRO_1000024288
Sites
	Metal binding	126	1	Manganese By similarity
	Metal binding	149	1	Manganese By similarity
	Metal binding	151	1	Manganese By similarity
	Metal binding	153	1	Manganese By similarity
	Metal binding	230	1	Manganese By similarity
	Metal binding	232	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2NRD3-1 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 709F31E00C181ED5	FASTA	307	33,526
	10 20 30 40 50 60 MTTLGHNYDN SLVSNAFGFL RLPLEFNPYA TDADWVITGI PFDMATSGRA GCRHGPAAIR 70 80 90 100 110 120 QVSTNLAWEG CRWPWDFDVR KRLKVVDCGD LVYEFGDAQD FCDKLQDHAE RLLAAGKRML 130 140 150 160 170 180 SFGGDHFVTL PLLCAHAKHF GKMALVHFDA HTDTYANGSK FDHGSMFYHA PNEGLISPAH 190 200 210 220 230 240 SVQIGIRTEF ERDNGFTVLD AGQVNDRSVD DILAQVKQIV GNLPVYLTFD IDCLDPSAAP 250 260 270 280 290 300 GTGTPVIGGL TSDRALKLVR GLQPLNIVGM DIVEVAPAYD QAQITALVAA TLALEMLYIQ GAKRGDD

References

[1]

"Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host." Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S. Genome Res. 16:149-156(2006) [PubMed: 16365377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP008232 Genomic DNA. Translation: BAE75292.1.
RefSeq	YP_455697.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2NRD3.
Genome annotation databases
GeneID	3868796.
GenomeReviews	Gene locus SG2017 in contig AP008232_GR.
KEGG	sgl:SG2017.
NMPDR	fig|343509.6.peg.4350.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2NRD3.
OMA	TNLAWEG.
Enzyme and pathway databases
BioCyc	SGLO343509:SG2017-MON.
Family and domain databases
HAMAP	MF_01418. [Tree]
InterPro	IPR005925. Agmatinase. IPR006035. Ureohydrolase. [Graphical view]
Gene3D	G3DSA:3.40.800.10. Ureohydrolase. 1 hit.
PANTHER	PTHR11358. Ureohydrolase. 1 hit.
Pfam	PF00491. Arginase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01230. agmatinase. 1 hit.
PROSITE	PS01053. ARGINASE_1. 1 hit. PS51409. ARGINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPEB_SODGM

Accession

Primary (citable) accession number: Q2NRD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 7, 2006
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)