Reviewed, UniProtKB/Swiss-Prot Q2NQZ3 (STHA_SODGM)

Names and origin

Protein names

Recommended name:
    Soluble pyridine nucleotide transhydrogenase
      Short name=STH
    EC=1.6.1.1
Alternative name(s):
    NAD(P)(+) transhydrogenase [B-specific]

Gene names

Name:	sthA
Synonyms:	udhA
Ordered Locus Names:	SG2157

Organism

Sodalis glossinidius (strain morsitans) [Complete proteome] [HAMAP]

Taxonomic identifier

343509 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Sodalis

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity.
Catalytic activity	NADPH + NAD(+) = NADP(+) + NADH.
Cofactor	Binds 1 FAD per subunit By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NADP metabolic process Inferred from electronic annotation. Source: HAMAP cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro NAD(P)+ transhydrogenase (B-specific) activity Inferred from electronic annotation. Source: HAMAP electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 465	465	Soluble pyridine nucleotide transhydrogenase		PRO_0000260244
Regions
	Nucleotide binding	36 – 45	10	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2NQZ3-1 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 114D111ED8442D53	FASTA	465	51,789
	10 20 30 40 50 60 MQPKYDYDAI IIGSGPGGEG AAMGLTKRGA RVAIIERYDN VGGGCTHWGT IPSKALRQAV 70 80 90 100 110 120 SRIIEINQSP LHGNTRLPHT GFSDILCHAD QVINQQTHMR QGFYERNHCQ IFTGEASFVD 130 140 150 160 170 180 EHQVQIHYGD NTTETLSAEN IVIACGSRPY QPQDVDFDHP RIYDSDSILD LKHDPHHVII 190 200 210 220 230 240 YGAGVIGCEY ASIFRGMNVK VDLINTRDRL LAFLDQEMSD ALSYHFWENG VVIRHNEEYE 250 260 270 280 290 300 EIKGLDDGVE VRFRSGKRMK ADCLLYANGR TGNTDTLKLD KVELEADSRG LIKVNSMYQT 310 320 330 340 350 360 AARHIYAVGD VIGYPSLASA AYDQGRIAAQ VIIKGQANVQ LIENIPTGIY TIPEISSVGK 370 380 390 400 410 420 TEQELTAMKV PYEVGRAQFK HLARAQIVGM NVGSLKLLFH RETKQILGIH CFGERAAEII 430 440 450 460 HIGQAIMEQK GEGNTIEYFV NTTFNYPTMA EAYRVAALNG LNRLF

References

[1]

"Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host." Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S. Genome Res. 16:149-156(2006) [PubMed: 16365377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP008232 Genomic DNA. Translation: BAE75432.1.
RefSeq	YP_455837.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3868266.
GenomeReviews	Gene locus SG2157 in contig AP008232_GR.
KEGG	sgl:SG2157.
NMPDR	fig|343509.6.peg.4758.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2NQZ3.
Enzyme and pathway databases
BioCyc	SGLO343509:SG2157-MON.
Family and domain databases
HAMAP	MF_00247. [Tree]
InterPro	IPR000759. Adrndx_reductase. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR000815. Hg_reductase. IPR001100. Pyr_nuc-diS_OxRdtase. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR001327. Pyr_OxRdtase_NAD_bd. [Graphical view]
Gene3D	G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view]
PRINTS	PR00419. ADXRDTASE. PR00368. FADPNR. PR00945. HGRDTASE. PR00411. PNDRDTASEI.
ProDom	PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

STHA_SODGM

Accession

Primary (citable) accession number: Q2NQZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	February 7, 2006
Last modified:	November 25, 2008
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)