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Q2NQZ3 (STHA_SODGM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Soluble pyridine nucleotide transhydrogenase
Short name=STH
EC=1.6.1.1
Alternative name(s):
NAD(P)(+) transhydrogenase [B-specific]
Gene names
Name:sthA
Synonyms:udhA
Ordered Locus Names:SG2157
OrganismSodalis glossinidius (strain morsitans) [Complete proteome] [HAMAP]
Taxonomic identifier343509 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Sodalis

Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity. HAMAP MF_00247

Catalytic activity

NADPH + NAD+ = NADP+ + NADH. HAMAP MF_00247

Cofactor

Binds 1 FAD per subunit By similarity. HAMAP MF_00247

Subcellular location

Cytoplasm By similarity HAMAP MF_00247.

Sequence similarities

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandFAD
Flavoprotein
NAD
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNAD(P)+ transhydrogenase (B-specific) activity

Inferred from electronic annotation. Source: EC

flavin adenine dinucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 465465Soluble pyridine nucleotide transhydrogenase HAMAP MF_00247
PRO_0000260244

Regions

Nucleotide binding36 – 4510FAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2NQZ3 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 114D111ED8442D53

FASTA46551,789
        10         20         30         40         50         60 
MQPKYDYDAI IIGSGPGGEG AAMGLTKRGA RVAIIERYDN VGGGCTHWGT IPSKALRQAV 

        70         80         90        100        110        120 
SRIIEINQSP LHGNTRLPHT GFSDILCHAD QVINQQTHMR QGFYERNHCQ IFTGEASFVD 

       130        140        150        160        170        180 
EHQVQIHYGD NTTETLSAEN IVIACGSRPY QPQDVDFDHP RIYDSDSILD LKHDPHHVII 

       190        200        210        220        230        240 
YGAGVIGCEY ASIFRGMNVK VDLINTRDRL LAFLDQEMSD ALSYHFWENG VVIRHNEEYE 

       250        260        270        280        290        300 
EIKGLDDGVE VRFRSGKRMK ADCLLYANGR TGNTDTLKLD KVELEADSRG LIKVNSMYQT 

       310        320        330        340        350        360 
AARHIYAVGD VIGYPSLASA AYDQGRIAAQ VIIKGQANVQ LIENIPTGIY TIPEISSVGK 

       370        380        390        400        410        420 
TEQELTAMKV PYEVGRAQFK HLARAQIVGM NVGSLKLLFH RETKQILGIH CFGERAAEII 

       430        440        450        460 
HIGQAIMEQK GEGNTIEYFV NTTFNYPTMA EAYRVAALNG LNRLF

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References

[1]"Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
Genome Res. 16:149-156(2006) [PubMed: 16365377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: morsitans.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008232 Genomic DNA. Translation: BAE75432.1.
RefSeqYP_455837.1. NC_007712.1.

3D structure databases

HSSPHSSP built from PDB template 2F5Z based on UniProtKB P09622.
ProteinModelPortalQ2NQZ3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2NQZ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3868266.
GenomeReviewsGene locus SG2157 in contig AP008232_GR.
KEGGsgl:SG2157.
NMPDRfig|343509.6.peg.4758.
PATRIC23656093. VBISodGlo61428_5321.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1249.
HOGENOMHBG515043.
OMAGEGNTIE.
PhylomeDBQ2NQZ3.
ProtClustDBPRK05249.

Enzyme and pathway databases

BioCycSGLO343509:SG2157-MONOMER.

Family and domain databases

HAMAPMF_00247. SthA.
[Tree]
InterProIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR022962. STH.
[Graphical view]
Gene3DG3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
KOK00322.
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF55424. FAD/NAD-linked_reductase_dimer. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSTHA_SODGM
AccessionPrimary (citable) accession number: Q2NQZ3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: February 7, 2006
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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