ID   HLDD_SODGM              Reviewed;         310 AA.
AC   Q2NQV7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=ADP-L-glycero-D-manno-heptose-6-epimerase;
DE            EC=5.1.3.20;
DE   AltName: Full=ADP-L-glycero-beta-D-manno-heptose-6-epimerase;
DE            Short=ADP-glyceromanno-heptose 6-epimerase;
DE            Short=ADP-hep 6-epimerase;
DE            Short=AGME;
GN   Name=hldD; OrderedLocusNames=SG2193;
OS   Sodalis glossinidius (strain morsitans).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Sodalis.
OX   NCBI_TaxID=343509;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16365377; DOI=10.1101/gr.4106106;
RA   Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K.,
RA   Hattori M., Aksoy S.;
RT   "Massive genome erosion and functional adaptations provide insights
RT   into the symbiotic lifestyle of Sodalis glossinidius in the tsetse
RT   host.";
RL   Genome Res. 16:149-156(2006).
CC   -!- FUNCTION: Catalyzes the interconversion between ADP-D-glycero-
CC       beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an
CC       epimerization at carbon 6 of the heptose (By similarity).
CC   -!- CATALYTIC ACTIVITY: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-
CC       D-manno-heptose.
CC   -!- COFACTOR: Binds 1 NADP(+) per subunit (By similarity).
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-
CC       manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose
CC       from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.
CC   -!- SUBUNIT: Homopentamer (By similarity).
CC   -!- DOMAIN: Contains a large N-terminal NADP-binding domain, and a
CC       smaller C-terminal substrate-binding domain (By similarity).
CC   -!- SIMILARITY: Belongs to the sugar epimerase family. HldD subfamily.
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DR   EMBL; AP008232; BAE75468.1; -; Genomic_DNA.
DR   RefSeq; YP_455873.1; -.
DR   SMR; Q2NQV7; 1-307.
DR   GeneID; 3867001; -.
DR   GenomeReviews; AP008232_GR; SG2193.
DR   KEGG; sgl:SG2193; -.
DR   NMPDR; fig|343509.6.peg.4837; -.
DR   HOGENOM; Q2NQV7; -.
DR   OMA; Q2NQV7; FGPNEYH.
DR   BioCyc; SGLO343509:SG2193-MON; -.
DR   GO; GO:0008712; F:ADP-glyceromanno-heptose 6-epimerase activity; IEA:HAMAP.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:HAMAP.
DR   GO; GO:0044237; P:cellular metabolic process; IEA:InterPro.
DR   HAMAP; MF_01601; -; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR011912; Heptose_epim.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR10366:SF29; Heptose_epim; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   TIGRFAMs; TIGR02197; heptose_epim; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Isomerase; NADP.
FT   CHAIN         1    310       ADP-L-glycero-D-manno-heptose-6-
FT                                epimerase.
FT                                /FTId=PRO_0000255745.
FT   NP_BIND      10     11       NADP (By similarity).
FT   NP_BIND      31     32       NADP (By similarity).
FT   NP_BIND      75     79       NADP (By similarity).
FT   REGION      201    204       Substrate binding (By similarity).
FT   ACT_SITE    140    140       Proton acceptor (By similarity).
FT   ACT_SITE    178    178       Proton acceptor (By similarity).
FT   BINDING      38     38       NADP (By similarity).
FT   BINDING      53     53       NADP (By similarity).
FT   BINDING      92     92       NADP (By similarity).
FT   BINDING     144    144       NADP (By similarity).
FT   BINDING     169    169       Substrate (By similarity).
FT   BINDING     170    170       NADP; via amide nitrogen (By similarity).
FT   BINDING     178    178       NADP (By similarity).
FT   BINDING     180    180       Substrate; via carbonyl oxygen (By
FT                                similarity).
FT   BINDING     187    187       Substrate (By similarity).
FT   BINDING     209    209       Substrate (By similarity).
FT   BINDING     272    272       Substrate (By similarity).
SQ   SEQUENCE   310 AA;  34952 MW;  E73D52ACCE90106A CRC64;
     MIVVTGGAGF IGSNIVKALN QIGYNDVLVV DNLKDGTKYA NLVDLNISDY MDKEDFIASI
     VAGDDFGDID AVFHEGACSS TTEWDGKYMM DNNYQYSKEL LHYCMERTIP FLYASSAATY
     GGRTEHFIED RQYEQPLNVY GYSKFLFDQY VRALLPQAES QICGFRYFNV YGPREGHKGG
     MASVAFHLNN QINAGENPKL FAGSEGFKRD FIYVGDVAAV NLWFWQNNVS GIFNCGTGRA
     ESFQAVSDAV LDYHKKGQLE YIPFPEKLKG RYQAYTQADL TQLRAAGYTQ PFKTVAEGVA
     EYLRWLNHNY
//