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Reviewed, UniProtKB/Swiss-Prot Q2NQV7 (HLDD_SODGM)

Last modified June 16, 2009. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    ADP-L-glycero-D-manno-heptose-6-epimerase
    EC=5.1.3.20
Alternative name(s):
    ADP-L-glycero-beta-D-manno-heptose-6-epimerase
      Short name=ADP-glyceromanno-heptose 6-epimerase
      Short name=ADP-hep 6-epimerase
      Short name=AGME
Gene names
Name: hldD
Ordered Locus Names: SG2193
OrganismSodalis glossinidius (strain morsitans) [Complete proteome] [HAMAP]
Taxonomic identifier343509 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Sodalis

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Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose By similarity.

Catalytic activity

ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose. HAMAP MF_01601

Cofactor

Binds 1 NADP+ per subunit By similarity.

Pathway

Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4. HAMAP MF_01601

Subunit structure

Homopentamer By similarity.

Domain

Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain By similarity.

Sequence similarities

Belongs to the sugar epimerase family. HldD subfamily.

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Ontologies

Keywords
   Biological processCarbohydrate metabolism
   LigandNADP
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarbohydrate metabolic process

Inferred from electronic annotation. Source: HAMAP

cellular metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionADP-glyceromanno-heptose 6-epimerase activity

Inferred from electronic annotation. Source: HAMAP

NADP or NADPH binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310ADP-L-glycero-D-manno-heptose-6-epimerase HAMAP MF_01601
PRO_0000255745

Regions

Nucleotide binding10 – 112NADP By similarity
Nucleotide binding31 – 322NADP By similarity
Nucleotide binding75 – 795NADP By similarity
Region201 – 2044Substrate binding By similarity

Sites

Active site1401Proton acceptor By similarity
Active site1781Proton acceptor By similarity
Binding site381NADP By similarity
Binding site531NADP By similarity
Binding site921NADP By similarity
Binding site1441NADP By similarity
Binding site1691Substrate By similarity
Binding site1701NADP; via amide nitrogen By similarity
Binding site1781NADP By similarity
Binding site1801Substrate; via carbonyl oxygen By similarity
Binding site1871Substrate By similarity
Binding site2091Substrate By similarity
Binding site2721Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q2NQV7-1 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: E73D52ACCE90106A

FASTA31034,952
        10         20         30         40         50         60 
MIVVTGGAGF IGSNIVKALN QIGYNDVLVV DNLKDGTKYA NLVDLNISDY MDKEDFIASI 

        70         80         90        100        110        120 
VAGDDFGDID AVFHEGACSS TTEWDGKYMM DNNYQYSKEL LHYCMERTIP FLYASSAATY 

       130        140        150        160        170        180 
GGRTEHFIED RQYEQPLNVY GYSKFLFDQY VRALLPQAES QICGFRYFNV YGPREGHKGG 

       190        200        210        220        230        240 
MASVAFHLNN QINAGENPKL FAGSEGFKRD FIYVGDVAAV NLWFWQNNVS GIFNCGTGRA 

       250        260        270        280        290        300 
ESFQAVSDAV LDYHKKGQLE YIPFPEKLKG RYQAYTQADL TQLRAAGYTQ PFKTVAEGVA 

       310 
EYLRWLNHNY

« Hide

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References

[1]"Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
Genome Res. 16:149-156(2006) [PubMed: 16365377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

AP008232 Genomic DNA. Translation: BAE75468.1.
RefSeqYP_455873.1.

3D structure databases

SMRQ2NQV7. Positions 1-307.
ModBaseSearch...

Genome annotation databases

GeneID3867001.
GenomeReviewsGene locus SG2193 in contig AP008232_GR.
KEGGsgl:SG2193.
NMPDRfig|343509.6.peg.4837.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ2NQV7.
OMAQ2NQV7. FGPNEYH.

Enzyme and pathway databases

BioCycSGLO343509:SG2193-MON.

Family and domain databases

HAMAPMF_01601.
[Tree]
InterProIPR001509. Epimerase_deHydtase.
IPR011912. Heptose_epim.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR10366:SF29. Heptose_epim. 1 hit.
PfamPF01370. Epimerase. 1 hit.
[Graphical view]
TIGRFAMsTIGR02197. heptose_epim. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameHLDD_SODGM
AccessionPrimary (citable) accession number: Q2NQV7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 7, 2006
Last modified: June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents