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Q2NQJ2 (AROB_SODGM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:SG2308
OrganismSodalis glossinidius (strain morsitans) [Complete proteome] [HAMAP]
Taxonomic identifier343509 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Sodalis

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3613613-dehydroquinate synthase HAMAP MF_00110
PRO_1000094624

Sequences

Sequence LengthMass (Da)Tools
Q2NQJ2 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: D2FA5FA8CD1FA809

FASTA36138,884
        10         20         30         40         50         60 
MERITVTLGE RSYPITIAAG LFNDPASFWP LTRGDSAMLV TNDRLAPLYL ESLCERLTQA 

        70         80         90        100        110        120 
GVKVDRVVLP DGEQNKSLTV LDQVFTALLA KSHGRDTTLI ALGGGVIGDL AGFAAASYQR 

       130        140        150        160        170        180 
GVRFIQAPTT LLSQVDSSVG GKTAVNHSLG KNMIGAFYQP ASVVIDLDCL NTLPRRELSS 

       190        200        210        220        230        240 
GLAEVIKYGI ILDAAFFAWL EDNLEALLAL EPQALAYCIR RCCELKADVV AADEREQGQR 

       250        260        270        280        290        300 
ALLNLGHTYG HAIETHMGYG NWLHGEAVAA GMMMAVRAAR RLGQFSDADA ERVSALLQRA 

       310        320        330        340        350        360 
GLTMSGPAEM APEDYLPHMM RDKKVIAGRL RLVLPVTLGN AEVRTGVADD MVVASIKDCQ 


A

« Hide

References

[1]"Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
Genome Res. 16:149-156(2006) [PubMed: 16365377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: morsitans.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008232 Genomic DNA. Translation: BAE75583.1.
RefSeqYP_455988.1. NC_007712.1.

3D structure databases

ProteinModelPortalQ2NQJ2.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2NQJ2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3866314.
GenomeReviewsGene locus SG2308 in contig AP008232_GR.
KEGGsgl:SG2308.
NMPDRfig|343509.6.peg.5017.
PATRIC23656667. VBISodGlo61428_5603.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAVMALEMS.
PhylomeDBQ2NQJ2.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycSGLO343509:SG2308-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_SODGM
AccessionPrimary (citable) accession number: Q2NQJ2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 7, 2006
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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