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Q2NQI3

- PCKA_SODGM

UniProt

Q2NQI3 - PCKA_SODGM

Protein

Phosphoenolpyruvate carboxykinase [ATP]

Gene

pckA

Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.UniRule annotation

    Catalytic activityi

    ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei64 – 641SubstrateUniRule annotation
    Binding sitei206 – 2061SubstrateUniRule annotation
    Metal bindingi212 – 2121ManganeseUniRule annotation
    Binding sitei212 – 2121ATPUniRule annotation
    Binding sitei212 – 2121SubstrateUniRule annotation
    Metal bindingi231 – 2311Manganese; via tele nitrogenUniRule annotation
    Binding sitei231 – 2311ATPUniRule annotation
    Metal bindingi268 – 2681ManganeseUniRule annotation
    Binding sitei296 – 2961ATPUniRule annotation
    Binding sitei332 – 3321ATPUniRule annotation
    Binding sitei332 – 3321SubstrateUniRule annotation
    Binding sitei454 – 4541ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi247 – 2559ATPUniRule annotation
    Nucleotide bindingi448 – 4492ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. phosphoenolpyruvate carboxykinase (ATP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    ATP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSGLO343509:GJJC-2398-MONOMER.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [ATP]UniRule annotation (EC:4.1.1.49UniRule annotation)
    Short name:
    PCKUniRule annotation
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckAUniRule annotation
    Ordered Locus Names:SG2317
    OrganismiSodalis glossinidius (strain morsitans)
    Taxonomic identifieri343509 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis
    ProteomesiUP000001932: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 539539Phosphoenolpyruvate carboxykinase [ATP]PRO_0000236947Add
    BLAST

    Proteomic databases

    PRIDEiQ2NQI3.

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi343509.SG2317.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2NQI3.
    SMRiQ2NQI3. Positions 6-538.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [ATP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1866.
    HOGENOMiHOG000271471.
    KOiK01610.
    OMAiSKTENAR.
    OrthoDBiEOG6DG2RK.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00453. PEPCK_ATP.
    InterProiIPR001272. PEP_carboxykinase_ATP.
    IPR013035. PEP_carboxykinase_C.
    IPR008210. PEP_carboxykinase_N.
    IPR015994. PEPCK_ATP_CS.
    [Graphical view]
    PfamiPF01293. PEPCK_ATP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006294. PEP_crbxkin. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.
    TIGRFAMsiTIGR00224. pckA. 1 hit.
    PROSITEiPS00532. PEPCK_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2NQI3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSESITPQQ WISYGITGYR ELVYNPGYDQ LFAEEIDPAL SGFERGTLTQ    50
    SGAVAVDTGI FTGRSPFDKY VVRDDKTRDT LWWSDQGKGA NDNHPLDQQT 100
    WVHLKRRVGK QLSGKRLFVI DAFCGANEDS RLRVRFVTEV AWQAHFVKNM 150
    FIRPSDEELR DFEPDFVVLN GAKCTNPDWR EQGLHSENFV AFNLTEGIQL 200
    IGGTWYGGEM KKGLFSVMNY LLPLKGIASM HCSANVGTDD DVALFFGLSG 250
    TGKTTLSTDP RRRLIGDDEH GWDDDGVFNF EGGCYAKTIR LSPEAEPEIY 300
    QAIRRNALLE NVVVRADGSV DYDDGSKTEN ARVSYPIDHI DNIVKPVSRA 350
    GHATRVIFLT ADAFGVLPPV ASLSMEQAQY HFLSGFTAKL GGTERGVVAP 400
    VPTFSACFGA AFLSLHPTAY ADVLAKRMHA AGARAYLVNT GWNGSGKRIS 450
    LKDTRTIINA ILRSDIDDAP TATLPVFNLT IPTALPGVNG AILDPRTTYA 500
    SVDEWRAKAD DLAQRFIDNF SKFTDTPAGV ALVSAGPQR 539
    Length:539
    Mass (Da):59,267
    Last modified:February 7, 2006 - v1
    Checksum:i96FF0A35152F74CB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008232 Genomic DNA. Translation: BAE75592.1.
    RefSeqiYP_455997.1. NC_007712.1.

    Genome annotation databases

    EnsemblBacteriaiBAE75592; BAE75592; SG2317.
    GeneIDi3866323.
    KEGGisgl:SG2317.
    PATRICi23656701. VBISodGlo61428_5620.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008232 Genomic DNA. Translation: BAE75592.1 .
    RefSeqi YP_455997.1. NC_007712.1.

    3D structure databases

    ProteinModelPortali Q2NQI3.
    SMRi Q2NQI3. Positions 6-538.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 343509.SG2317.

    Proteomic databases

    PRIDEi Q2NQI3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE75592 ; BAE75592 ; SG2317 .
    GeneIDi 3866323.
    KEGGi sgl:SG2317.
    PATRICi 23656701. VBISodGlo61428_5620.

    Phylogenomic databases

    eggNOGi COG1866.
    HOGENOMi HOG000271471.
    KOi K01610.
    OMAi SKTENAR.
    OrthoDBi EOG6DG2RK.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    BioCyci SGLO343509:GJJC-2398-MONOMER.

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00453. PEPCK_ATP.
    InterProi IPR001272. PEP_carboxykinase_ATP.
    IPR013035. PEP_carboxykinase_C.
    IPR008210. PEP_carboxykinase_N.
    IPR015994. PEPCK_ATP_CS.
    [Graphical view ]
    Pfami PF01293. PEPCK_ATP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006294. PEP_crbxkin. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    TIGRFAMsi TIGR00224. pckA. 1 hit.
    PROSITEi PS00532. PEPCK_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
      Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
      Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: morsitans.

    Entry informationi

    Entry nameiPCKA_SODGM
    AccessioniPrimary (citable) accession number: Q2NQI3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3