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Q2NQI3

- PCKA_SODGM

UniProt

Q2NQI3 - PCKA_SODGM

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Protein
Phosphoenolpyruvate carboxykinase [ATP]
Gene
pckA, SG2317
Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA By similarity.UniRule annotation

Catalytic activityi

ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 641Substrate By similarity
Binding sitei206 – 2061Substrate By similarity
Metal bindingi212 – 2121Manganese By similarity
Binding sitei212 – 2121ATP By similarity
Binding sitei212 – 2121Substrate By similarity
Metal bindingi231 – 2311Manganese; via tele nitrogen By similarity
Binding sitei231 – 2311ATP By similarity
Metal bindingi268 – 2681Manganese By similarity
Binding sitei296 – 2961ATP By similarity
Binding sitei332 – 3321ATP By similarity
Binding sitei332 – 3321Substrate By similarity
Binding sitei454 – 4541ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi247 – 2559ATP By similarity
Nucleotide bindingi448 – 4492ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. phosphoenolpyruvate carboxykinase (ATP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

ATP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSGLO343509:GJJC-2398-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [ATP] (EC:4.1.1.49)
Short name:
PCK
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckA
Ordered Locus Names:SG2317
OrganismiSodalis glossinidius (strain morsitans)
Taxonomic identifieri343509 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis
ProteomesiUP000001932: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 539539Phosphoenolpyruvate carboxykinase [ATP]UniRule annotation
PRO_0000236947Add
BLAST

Proteomic databases

PRIDEiQ2NQI3.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi343509.SG2317.

Structurei

3D structure databases

ProteinModelPortaliQ2NQI3.
SMRiQ2NQI3. Positions 6-538.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1866.
HOGENOMiHOG000271471.
KOiK01610.
OMAiSKTENAR.
OrthoDBiEOG6DG2RK.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00453. PEPCK_ATP.
InterProiIPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
IPR015994. PEPCK_ATP_CS.
[Graphical view]
PfamiPF01293. PEPCK_ATP. 1 hit.
[Graphical view]
PIRSFiPIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
TIGRFAMsiTIGR00224. pckA. 1 hit.
PROSITEiPS00532. PEPCK_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2NQI3-1 [UniParc]FASTAAdd to Basket

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MVSESITPQQ WISYGITGYR ELVYNPGYDQ LFAEEIDPAL SGFERGTLTQ    50
SGAVAVDTGI FTGRSPFDKY VVRDDKTRDT LWWSDQGKGA NDNHPLDQQT 100
WVHLKRRVGK QLSGKRLFVI DAFCGANEDS RLRVRFVTEV AWQAHFVKNM 150
FIRPSDEELR DFEPDFVVLN GAKCTNPDWR EQGLHSENFV AFNLTEGIQL 200
IGGTWYGGEM KKGLFSVMNY LLPLKGIASM HCSANVGTDD DVALFFGLSG 250
TGKTTLSTDP RRRLIGDDEH GWDDDGVFNF EGGCYAKTIR LSPEAEPEIY 300
QAIRRNALLE NVVVRADGSV DYDDGSKTEN ARVSYPIDHI DNIVKPVSRA 350
GHATRVIFLT ADAFGVLPPV ASLSMEQAQY HFLSGFTAKL GGTERGVVAP 400
VPTFSACFGA AFLSLHPTAY ADVLAKRMHA AGARAYLVNT GWNGSGKRIS 450
LKDTRTIINA ILRSDIDDAP TATLPVFNLT IPTALPGVNG AILDPRTTYA 500
SVDEWRAKAD DLAQRFIDNF SKFTDTPAGV ALVSAGPQR 539
Length:539
Mass (Da):59,267
Last modified:February 7, 2006 - v1
Checksum:i96FF0A35152F74CB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008232 Genomic DNA. Translation: BAE75592.1.
RefSeqiYP_455997.1. NC_007712.1.

Genome annotation databases

EnsemblBacteriaiBAE75592; BAE75592; SG2317.
GeneIDi3866323.
KEGGisgl:SG2317.
PATRICi23656701. VBISodGlo61428_5620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008232 Genomic DNA. Translation: BAE75592.1 .
RefSeqi YP_455997.1. NC_007712.1.

3D structure databases

ProteinModelPortali Q2NQI3.
SMRi Q2NQI3. Positions 6-538.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 343509.SG2317.

Proteomic databases

PRIDEi Q2NQI3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE75592 ; BAE75592 ; SG2317 .
GeneIDi 3866323.
KEGGi sgl:SG2317.
PATRICi 23656701. VBISodGlo61428_5620.

Phylogenomic databases

eggNOGi COG1866.
HOGENOMi HOG000271471.
KOi K01610.
OMAi SKTENAR.
OrthoDBi EOG6DG2RK.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci SGLO343509:GJJC-2398-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00453. PEPCK_ATP.
InterProi IPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
IPR015994. PEPCK_ATP_CS.
[Graphical view ]
Pfami PF01293. PEPCK_ATP. 1 hit.
[Graphical view ]
PIRSFi PIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
TIGRFAMsi TIGR00224. pckA. 1 hit.
PROSITEi PS00532. PEPCK_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
    Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
    Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: morsitans.

Entry informationi

Entry nameiPCKA_SODGM
AccessioniPrimary (citable) accession number: Q2NQI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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