ID   Q2NQF3_SODGM            Unreviewed;       850 AA.
AC   Q2NQF3;
DT   07-FEB-2006, integrated into UniProtKB/TrEMBL.
DT   07-FEB-2006, sequence version 1.
DT   27-MAR-2024, entry version 98.
DE   RecName: Full=Adenylate cyclase {ECO:0000256|ARBA:ARBA00021420, ECO:0000256|RuleBase:RU000604};
DE            EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201, ECO:0000256|RuleBase:RU000604};
GN   Name=cyaA {ECO:0000313|EMBL:CRL46702.1};
GN   OrderedLocusNames=SG2347 {ECO:0000313|EMBL:BAE75622.1};
GN   ORFNames=SGGMMB4_05528 {ECO:0000313|EMBL:CRL46702.1};
OS   Sodalis glossinidius (strain morsitans).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Bruguierivoracaceae; Sodalis.
OX   NCBI_TaxID=343509 {ECO:0000313|EMBL:BAE75622.1, ECO:0000313|Proteomes:UP000001932};
RN   [1] {ECO:0000313|EMBL:BAE75622.1, ECO:0000313|Proteomes:UP000001932}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Morsitans {ECO:0000313|EMBL:BAE75622.1}, and morsitans
RC   {ECO:0000313|Proteomes:UP000001932};
RX   PubMed=16365377; DOI=10.1101/gr.4106106;
RA   Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M.,
RA   Aksoy S.;
RT   "Massive genome erosion and functional adaptations provide insights into
RT   the symbiotic lifestyle of Sodalis glossinidius in the tsetse host.";
RL   Genome Res. 16:149-156(2006).
RN   [2] {ECO:0000313|EMBL:CRL46702.1, ECO:0000313|Proteomes:UP000245838}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B4 {ECO:0000313|EMBL:CRL46702.1}, and morsitans
RC   {ECO:0000313|Proteomes:UP000245838};
RA   Goodhead I.;
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001593,
CC         ECO:0000256|RuleBase:RU000604};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|RuleBase:RU000604}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-1 family.
CC       {ECO:0000256|ARBA:ARBA00007901, ECO:0000256|RuleBase:RU004184}.
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DR   EMBL; AP008232; BAE75622.1; -; Genomic_DNA.
DR   EMBL; LN854557; CRL46702.1; -; Genomic_DNA.
DR   RefSeq; WP_011412154.1; NZ_LN854557.1.
DR   STRING; 343509.SG2347; -.
DR   KEGG; sgl:SG2347; -.
DR   eggNOG; COG3072; Bacteria.
DR   HOGENOM; CLU_013280_0_0_6; -.
DR   OrthoDB; 5571448at2; -.
DR   BioCyc; SGLO343509:SGP1_RS21320-MONOMER; -.
DR   Proteomes; UP000001932; Chromosome.
DR   Proteomes; UP000245838; Chromosome sggmmb4_Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000274; Adenylate_cyclase_1.
DR   InterPro; IPR024686; Adenylate_cyclase_1_CS.
DR   InterPro; IPR024685; Adenylate_cyclase_1_N.
DR   PANTHER; PTHR38760; ADENYLATE CYCLASE; 1.
DR   PANTHER; PTHR38760:SF1; ADENYLATE CYCLASE; 1.
DR   Pfam; PF12633; Adenyl_cycl_N; 1.
DR   Pfam; PF01295; Adenylate_cycl; 1.
DR   PIRSF; PIRSF001444; Adenylate_cycl; 1.
DR   PROSITE; PS01092; ADENYLATE_CYCLASE_1_1; 1.
DR   PROSITE; PS01093; ADENYLATE_CYCLASE_1_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998,
KW   ECO:0000256|RuleBase:RU000604}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000604};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          5..200
FT                   /note="Adenylate cyclase class-I N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12633"
SQ   SEQUENCE   850 AA;  97085 MW;  5C7B52E77826C14E CRC64;
     MYFYIETLKQ RLDAINQLRV DRALAAMGPD FQHVYSLLPT LLHFHHPMLP GYLDGTVPHG
     ICFYSPDETQ RAWLDDIGRQ AGAAVAAPDS GEQPITGVYS MGSTSSIGQN ANSDLDIWVC
     HQSWLDNEER AQLQRKCHLL EQWANRRGVD VNFFLIDENR FRHNESGSLG DEDCGSTQHI
     LLLDEFYRTA VRMGGKRILW KMVPGDEEAH YDEYVLSLYA RGALTPNEWL DLGGLGTLSA
     EEYFGASLWQ LYKSIDSPYK AVLKTLLLEA YSWEYPHTEL LAMKIKQRLH DGEIVSFGLD
     PYCMMLERVT YYLTQINDMT RLDMVRRCFY LKVCEKLSQD PAGTPWRREI LTQLVTSWGW
     DDARLKMLDD RANWKIAQVR EAHNELLDAM MQSYRNLIRF ARRNNLSVSA SPQDIGVLTR
     KLYAAFEALP GKVTLLNPQI SPDLSELHLT FIYVPQGRAN RTGWYLYNQS PSMDSIISHQ
     PLEYNRYLNK LVAWAWFNGL LTRSTQVHIK GSDTCDSAKL NELIADVAGH FPLRVPTPTP
     KALCSPCEIR HLAIIVNLEH DPTAVFRNQV VHFDFRKLDV FSFGQQQQCL VGSIDLLYRN
     SWNEVRTLHF SGEQAVLEAL KTILGKMHQD AAPPDTVEVF CYSQHLRGLI RTRVQQLVSE
     CIELRLSSTR QDPARFKAVR VAGQTWGLFF ERLSVSVQKL ENAVEFYGAI SNNKLHGLSI
     QMETEQVHLP PVVDGFASEG IIQFFFEDTT DDSGFNIYIL DETNRVEAYH HCEGSKEELV
     RDVSRFYSSS HDRFTYGSSF INFNLPQFYQ IMNLDGRIQV VPFRSSVLSH LCGAPFDNGA
     PPLAQNARSS
//