ID   GPPA_SODGM              Reviewed;         499 AA.
AC   Q2NQB1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   16-JUN-2009, entry version 17.
DE   RecName: Full=Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase;
DE            EC=3.6.1.40;
DE   AltName: Full=Guanosine pentaphosphate phosphohydrolase;
DE   AltName: Full=pppGpp-5'-phosphohydrolase;
GN   Name=gppA; OrderedLocusNames=SG2389;
OS   Sodalis glossinidius (strain morsitans).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Sodalis.
OX   NCBI_TaxID=343509;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16365377; DOI=10.1101/gr.4106106;
RA   Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K.,
RA   Hattori M., Aksoy S.;
RT   "Massive genome erosion and functional adaptations provide insights
RT   into the symbiotic lifestyle of Sodalis glossinidius in the tsetse
RT   host.";
RL   Genome Res. 16:149-156(2006).
CC   -!- FUNCTION: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate
CC       (pppGpp) is a cytoplasmic signaling molecule which together with
CC       ppGpp controls the "stringent response", an adaptive process that
CC       allows bacteria to respond to amino acid starvation, resulting in
CC       the coordinated regulation of numerous cellular activities (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Guanosine 5'-triphosphate,3'-diphosphate +
CC       H(2)O = guanosine 5'-diphosphate,3'-diphosphate + phosphate.
CC   -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP:
CC       step 1/2.
CC   -!- SIMILARITY: Belongs to the gppA/ppx family. GppA subfamily.
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DR   EMBL; AP008232; BAE75664.1; -; Genomic_DNA.
DR   RefSeq; YP_456069.1; -.
DR   GeneID; 3867360; -.
DR   GenomeReviews; AP008232_GR; SG2389.
DR   KEGG; sgl:SG2389; -.
DR   NMPDR; fig|343509.6.peg.5161; -.
DR   HOGENOM; Q2NQB1; -.
DR   OMA; Q2NQB1; QYTDLGW.
DR   BioCyc; SGLO343509:SG2389-MON; -.
DR   GO; GO:0008894; F:guanosine-5'-triphosphate,3'-diphosphate di...; IEA:HAMAP.
DR   HAMAP; MF_01550; -; 1.
DR   InterPro; IPR003695; Ppx_GppA.
DR   Pfam; PF02541; Ppx-GppA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase.
FT   CHAIN         1    499       Guanosine-5'-triphosphate,3'-diphosphate
FT                                pyrophosphatase.
FT                                /FTId=PRO_0000314500.
SQ   SEQUENCE   499 AA;  55655 MW;  01C8F3EABF178AA8 CRC64;
     MIRATSLYAA IDLGSNSFHM LVVREVAGTL QTLARIKRKV RLAAGLYGDN RLSSDAMQRG
     WQCLRLFAEH LQDIPPTQVR VVATATLRLA TNAAEFLGPA SAILGCPVQV ISGEEEARLI
     YQGVAHTTGG SDERLVVDIG GGSTELVVGR GAQALELFSL EMGCVTWLER YFNDRSLTRE
     NFERAEQAAR EKIRPVAFRL LAQGWQVCVG ASGTVQALQE IMVAQGMDEH ITLSKLLQLK
     QRAIHCGKLE ELEIEGLTLE RALVFPSGLA ILLAVFAELG ITTMTLAGGA LREGMMYGMM
     ALPVGGDIRQ RTLENLQRRY QLDTEQAQRV TWLADGFARQ VAEAWQLDER CFTLLRCASM
     IHEIGLSIDI KRAPQHAAYL VRHTDLPGFT PAQQKLIATL LQNQSNHINL TQLNEQNCLA
     PRIAQRLCRL MRLAIIFASR RRDDALPAVE LRAAEETLYV ILPQGWLSQH PLRAEYLEQE
     SQWQSYVHWP LLLEETSQV
//