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Q2NQB1

- GPPA_SODGM

UniProt

Q2NQB1 - GPPA_SODGM

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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene
gppA, SG2389
Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSGLO343509:GJJC-2474-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC:3.6.1.40)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene namesi
Name:gppA
Ordered Locus Names:SG2389
OrganismiSodalis glossinidius (strain morsitans)
Taxonomic identifieri343509 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis
ProteomesiUP000001932: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotationPRO_0000314500Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi343509.SG2389.

Structurei

3D structure databases

ProteinModelPortaliQ2NQB1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0248.
KOiK01524.
OMAiGLHIEYK.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2NQB1-1 [UniParc]FASTAAdd to Basket

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MIRATSLYAA IDLGSNSFHM LVVREVAGTL QTLARIKRKV RLAAGLYGDN    50
RLSSDAMQRG WQCLRLFAEH LQDIPPTQVR VVATATLRLA TNAAEFLGPA 100
SAILGCPVQV ISGEEEARLI YQGVAHTTGG SDERLVVDIG GGSTELVVGR 150
GAQALELFSL EMGCVTWLER YFNDRSLTRE NFERAEQAAR EKIRPVAFRL 200
LAQGWQVCVG ASGTVQALQE IMVAQGMDEH ITLSKLLQLK QRAIHCGKLE 250
ELEIEGLTLE RALVFPSGLA ILLAVFAELG ITTMTLAGGA LREGMMYGMM 300
ALPVGGDIRQ RTLENLQRRY QLDTEQAQRV TWLADGFARQ VAEAWQLDER 350
CFTLLRCASM IHEIGLSIDI KRAPQHAAYL VRHTDLPGFT PAQQKLIATL 400
LQNQSNHINL TQLNEQNCLA PRIAQRLCRL MRLAIIFASR RRDDALPAVE 450
LRAAEETLYV ILPQGWLSQH PLRAEYLEQE SQWQSYVHWP LLLEETSQV 499
Length:499
Mass (Da):55,655
Last modified:February 7, 2006 - v1
Checksum:i01C8F3EABF178AA8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008232 Genomic DNA. Translation: BAE75664.1.
RefSeqiWP_011412195.1. NC_007712.1.
YP_456069.1. NC_007712.1.

Genome annotation databases

EnsemblBacteriaiBAE75664; BAE75664; SG2389.
GeneIDi3867360.
KEGGisgl:SG2389.
PATRICi23657009. VBISodGlo61428_5770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008232 Genomic DNA. Translation: BAE75664.1 .
RefSeqi WP_011412195.1. NC_007712.1.
YP_456069.1. NC_007712.1.

3D structure databases

ProteinModelPortali Q2NQB1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 343509.SG2389.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE75664 ; BAE75664 ; SG2389 .
GeneIDi 3867360.
KEGGi sgl:SG2389.
PATRICi 23657009. VBISodGlo61428_5770.

Phylogenomic databases

eggNOGi COG0248.
KOi K01524.
OMAi GLHIEYK.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci SGLO343509:GJJC-2474-MONOMER.

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
    Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
    Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: morsitans.

Entry informationi

Entry nameiGPPA_SODGM
AccessioniPrimary (citable) accession number: Q2NQB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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