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Q2NQB1 (GPPA_SODGM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:SG2389
OrganismSodalis glossinidius (strain morsitans) [Complete proteome] [HAMAP]
Taxonomic identifier343509 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis

Protein attributes

Sequence length499 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 499499Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_0000314500

Sequences

Sequence LengthMass (Da)Tools
Q2NQB1 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 01C8F3EABF178AA8

FASTA49955,655
        10         20         30         40         50         60 
MIRATSLYAA IDLGSNSFHM LVVREVAGTL QTLARIKRKV RLAAGLYGDN RLSSDAMQRG 

        70         80         90        100        110        120 
WQCLRLFAEH LQDIPPTQVR VVATATLRLA TNAAEFLGPA SAILGCPVQV ISGEEEARLI 

       130        140        150        160        170        180 
YQGVAHTTGG SDERLVVDIG GGSTELVVGR GAQALELFSL EMGCVTWLER YFNDRSLTRE 

       190        200        210        220        230        240 
NFERAEQAAR EKIRPVAFRL LAQGWQVCVG ASGTVQALQE IMVAQGMDEH ITLSKLLQLK 

       250        260        270        280        290        300 
QRAIHCGKLE ELEIEGLTLE RALVFPSGLA ILLAVFAELG ITTMTLAGGA LREGMMYGMM 

       310        320        330        340        350        360 
ALPVGGDIRQ RTLENLQRRY QLDTEQAQRV TWLADGFARQ VAEAWQLDER CFTLLRCASM 

       370        380        390        400        410        420 
IHEIGLSIDI KRAPQHAAYL VRHTDLPGFT PAQQKLIATL LQNQSNHINL TQLNEQNCLA 

       430        440        450        460        470        480 
PRIAQRLCRL MRLAIIFASR RRDDALPAVE LRAAEETLYV ILPQGWLSQH PLRAEYLEQE 

       490 
SQWQSYVHWP LLLEETSQV 

« Hide

References

[1]"Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: morsitans.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008232 Genomic DNA. Translation: BAE75664.1.
RefSeqYP_456069.1. NC_007712.1.

3D structure databases

ProteinModelPortalQ2NQB1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING343509.SG2389.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE75664; BAE75664; SG2389.
GeneID3867360.
KEGGsgl:SG2389.
PATRIC23657009. VBISodGlo61428_5770.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0248.
KOK01524.
OMAPPRVAEH.
OrthoDBEOG6M6JN6.
ProtClustDBPRK11031.

Enzyme and pathway databases

BioCycSGLO343509:GJJC-2474-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPPA_SODGM
AccessionPrimary (citable) accession number: Q2NQB1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: February 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways