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Q2NQB1

- GPPA_SODGM

UniProt

Q2NQB1 - GPPA_SODGM

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciSGLO343509:GJJC-2474-MONOMER.
    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:SG2389
    OrganismiSodalis glossinidius (strain morsitans)
    Taxonomic identifieri343509 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSodalis
    ProteomesiUP000001932: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 499499Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000314500Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi343509.SG2389.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2NQB1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    KOiK01524.
    OMAiGLHIEYK.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    HAMAPiMF_01550. GppA.
    InterProiIPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2NQB1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIRATSLYAA IDLGSNSFHM LVVREVAGTL QTLARIKRKV RLAAGLYGDN    50
    RLSSDAMQRG WQCLRLFAEH LQDIPPTQVR VVATATLRLA TNAAEFLGPA 100
    SAILGCPVQV ISGEEEARLI YQGVAHTTGG SDERLVVDIG GGSTELVVGR 150
    GAQALELFSL EMGCVTWLER YFNDRSLTRE NFERAEQAAR EKIRPVAFRL 200
    LAQGWQVCVG ASGTVQALQE IMVAQGMDEH ITLSKLLQLK QRAIHCGKLE 250
    ELEIEGLTLE RALVFPSGLA ILLAVFAELG ITTMTLAGGA LREGMMYGMM 300
    ALPVGGDIRQ RTLENLQRRY QLDTEQAQRV TWLADGFARQ VAEAWQLDER 350
    CFTLLRCASM IHEIGLSIDI KRAPQHAAYL VRHTDLPGFT PAQQKLIATL 400
    LQNQSNHINL TQLNEQNCLA PRIAQRLCRL MRLAIIFASR RRDDALPAVE 450
    LRAAEETLYV ILPQGWLSQH PLRAEYLEQE SQWQSYVHWP LLLEETSQV 499
    Length:499
    Mass (Da):55,655
    Last modified:February 7, 2006 - v1
    Checksum:i01C8F3EABF178AA8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008232 Genomic DNA. Translation: BAE75664.1.
    RefSeqiWP_011412195.1. NC_007712.1.
    YP_456069.1. NC_007712.1.

    Genome annotation databases

    EnsemblBacteriaiBAE75664; BAE75664; SG2389.
    GeneIDi3867360.
    KEGGisgl:SG2389.
    PATRICi23657009. VBISodGlo61428_5770.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008232 Genomic DNA. Translation: BAE75664.1 .
    RefSeqi WP_011412195.1. NC_007712.1.
    YP_456069.1. NC_007712.1.

    3D structure databases

    ProteinModelPortali Q2NQB1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 343509.SG2389.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE75664 ; BAE75664 ; SG2389 .
    GeneIDi 3867360.
    KEGGi sgl:SG2389.
    PATRICi 23657009. VBISodGlo61428_5770.

    Phylogenomic databases

    eggNOGi COG0248.
    KOi K01524.
    OMAi GLHIEYK.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .
    BioCyci SGLO343509:GJJC-2474-MONOMER.

    Family and domain databases

    HAMAPi MF_01550. GppA.
    InterProi IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host."
      Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S.
      Genome Res. 16:149-156(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: morsitans.

    Entry informationi

    Entry nameiGPPA_SODGM
    AccessioniPrimary (citable) accession number: Q2NQB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3