Reviewed, UniProtKB/Swiss-Prot Q2NQB1 (GPPA_SODGM)

Names and origin

Protein names

Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase
    EC=3.6.1.40
Alternative name(s):
    Guanosine pentaphosphate phosphohydrolase
    pppGpp-5'-phosphohydrolase

Gene names

Name:	gppA
Ordered Locus Names:	SG2389

Organism

Sodalis glossinidius (strain morsitans) [Complete proteome] [HAMAP]

Taxonomic identifier

343509 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Sodalis

Protein attributes

Sequence length	499 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity.
Catalytic activity	Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate. HAMAP MF_01550
Pathway	Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP MF_01550
Sequence similarities	Belongs to the gppA/ppx family. GppA subfamily.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 499	499	Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP MF_01550		PRO_0000314500

Sequences

	Sequence		Length	Mass (Da)
	Q2NQB1-1 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 01C8F3EABF178AA8	FASTA	499	55,655
	10 20 30 40 50 60 MIRATSLYAA IDLGSNSFHM LVVREVAGTL QTLARIKRKV RLAAGLYGDN RLSSDAMQRG 70 80 90 100 110 120 WQCLRLFAEH LQDIPPTQVR VVATATLRLA TNAAEFLGPA SAILGCPVQV ISGEEEARLI 130 140 150 160 170 180 YQGVAHTTGG SDERLVVDIG GGSTELVVGR GAQALELFSL EMGCVTWLER YFNDRSLTRE 190 200 210 220 230 240 NFERAEQAAR EKIRPVAFRL LAQGWQVCVG ASGTVQALQE IMVAQGMDEH ITLSKLLQLK 250 260 270 280 290 300 QRAIHCGKLE ELEIEGLTLE RALVFPSGLA ILLAVFAELG ITTMTLAGGA LREGMMYGMM 310 320 330 340 350 360 ALPVGGDIRQ RTLENLQRRY QLDTEQAQRV TWLADGFARQ VAEAWQLDER CFTLLRCASM 370 380 390 400 410 420 IHEIGLSIDI KRAPQHAAYL VRHTDLPGFT PAQQKLIATL LQNQSNHINL TQLNEQNCLA 430 440 450 460 470 480 PRIAQRLCRL MRLAIIFASR RRDDALPAVE LRAAEETLYV ILPQGWLSQH PLRAEYLEQE 490 SQWQSYVHWP LLLEETSQV

References

[1]

"Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host." Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M., Aksoy S. Genome Res. 16:149-156(2006) [PubMed: 16365377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP008232 Genomic DNA. Translation: BAE75664.1.
RefSeq	YP_456069.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3867360.
GenomeReviews	Gene locus SG2389 in contig AP008232_GR.
KEGG	sgl:SG2389.
NMPDR	fig|343509.6.peg.5161.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2NQB1.
OMA	Q2NQB1. QYTDLGW.
Enzyme and pathway databases
BioCyc	SGLO343509:SG2389-MON.
Family and domain databases
HAMAP	MF_01550. [Tree]
InterPro	IPR003695. Ppx_GppA. [Graphical view]
Pfam	PF02541. Ppx-GppA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPPA_SODGM

Accession

Primary (citable) accession number: Q2NQB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 7, 2006
Last modified:	June 16, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)