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Q2NNR5 (CLTR1_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteinyl leukotriene receptor 1

Short name=CysLTR1
Alternative name(s):
Cysteinyl leukotriene D4 receptor
Short name=LTD4 receptor
Gene names
Name:CYSLTR1
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340Cysteinyl leukotriene receptor 1
PRO_0000281573

Regions

Topological domain1 – 3131Extracellular Potential
Transmembrane32 – 5221Helical; Name=1; Potential
Topological domain53 – 608Cytoplasmic Potential
Transmembrane61 – 8121Helical; Name=2; Potential
Topological domain82 – 10928Extracellular Potential
Transmembrane110 – 13021Helical; Name=3; Potential
Topological domain131 – 14414Cytoplasmic Potential
Transmembrane145 – 16521Helical; Name=4; Potential
Topological domain166 – 19631Extracellular Potential
Transmembrane197 – 21721Helical; Name=5; Potential
Topological domain218 – 23316Cytoplasmic Potential
Transmembrane234 – 25421Helical; Name=6; Potential
Topological domain255 – 27925Extracellular Potential
Transmembrane280 – 30021Helical; Name=7; Potential
Topological domain301 – 34040Cytoplasmic Potential

Amino acid modifications

Glycosylation141N-linked (GlcNAc...) Potential
Glycosylation1721N-linked (GlcNAc...) Potential
Glycosylation2651N-linked (GlcNAc...) Potential
Disulfide bond99 ↔ 176 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2NNR5 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: DE544F975FB65F76

FASTA34038,984
        10         20         30         40         50         60 
MDETGNPTIP PASNNTCYDS IDDFRNQVYS TLYSMISVVG FFGNGFVLYV LVKTYHEKSA 

        70         80         90        100        110        120 
FQVYMINLAV ADLLCVCTLP LRVAYYVHKG IWLFGDFLCR LSTYALYVNL YCSIFFMTAM 

       130        140        150        160        170        180 
SFFRCVAIVF PVQNISLVTQ KKARLVCIAI WMFVILTSSP FLMANTYKDE KNNTKCFEPP 

       190        200        210        220        230        240 
QDNQAKNYVL ILHYVSLFIG FIIPFITIIV CYTMIIFTLL KSSMKKNLSS RKRAIGMIIV 

       250        260        270        280        290        300 
VTAAFLVSFM PYHIQRTIHL HFLHNKTKPC DSILRMQKSV VITLSLAASN CCFDPLLYFF 

       310        320        330        340 
SGGNFRRRLS TIRKYSLSSM TYIPKKKTSL PQKGKDICKE 

« Hide

References

[1]"Molecular cloning and functional characterization of guinea pig cysteinyl leukotriene receptor 1 and 2."
Ito Y., Nishimura Y., Tanaka T.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY236968 mRNA. Translation: AAP75558.1.
RefSeqNP_001166412.1. NM_001172941.2.

3D structure databases

ProteinModelPortalQ2NNR5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10141.ENSCPOP00000001902.

Chemistry

BindingDBQ2NNR5.
ChEMBLCHEMBL5645.

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCPOT00000002128; ENSCPOP00000001902; ENSCPOG00000002100.
GeneID100135514.

Organism-specific databases

CTD10800.

Phylogenomic databases

eggNOGNOG119185.
GeneTreeENSGT00750000117402.
HOGENOMHOG000236328.
HOVERGENHBG099611.
InParanoidQ2NNR5.
OMAPQDNQAK.
OrthoDBEOG7992R9.
TreeFamTF350009.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR013310. CLT1_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01902. CYSLT1RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCLTR1_CAVPO
AccessionPrimary (citable) accession number: Q2NNR5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: February 7, 2006
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries