SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q2NNR5

- CLTR1_CAVPO

UniProt

Q2NNR5 - CLTR1_CAVPO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cysteinyl leukotriene receptor 1

Gene
CYSLTR1
Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system By similarity.

GO - Molecular functioni

  1. leukotriene receptor activity Source: Ensembl

GO - Biological processi

  1. calcium ion transport Source: Ensembl
  2. chemotaxis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 1
Short name:
CysLTR1
Alternative name(s):
Cysteinyl leukotriene D4 receptor
Short name:
LTD4 receptor
Gene namesi
Name:CYSLTR1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131Extracellular Reviewed predictionAdd
BLAST
Transmembranei32 – 5221Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini53 – 608Cytoplasmic Reviewed prediction
Transmembranei61 – 8121Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini82 – 10928Extracellular Reviewed predictionAdd
BLAST
Transmembranei110 – 13021Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini131 – 14414Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei145 – 16521Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini166 – 19631Extracellular Reviewed predictionAdd
BLAST
Transmembranei197 – 21721Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini218 – 23316Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei234 – 25421Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini255 – 27925Extracellular Reviewed predictionAdd
BLAST
Transmembranei280 – 30021Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini301 – 34040Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Cysteinyl leukotriene receptor 1PRO_0000281573Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi99 ↔ 176 By similarity
Glycosylationi172 – 1721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi265 – 2651N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000001902.

Structurei

3D structure databases

ProteinModelPortaliQ2NNR5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG119185.
GeneTreeiENSGT00750000117402.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ2NNR5.
OMAiPQDNQAK.
OrthoDBiEOG7992R9.
TreeFamiTF350009.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR013310. CLT1_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01902. CYSLT1RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2NNR5-1 [UniParc]FASTAAdd to Basket

« Hide

MDETGNPTIP PASNNTCYDS IDDFRNQVYS TLYSMISVVG FFGNGFVLYV    50
LVKTYHEKSA FQVYMINLAV ADLLCVCTLP LRVAYYVHKG IWLFGDFLCR 100
LSTYALYVNL YCSIFFMTAM SFFRCVAIVF PVQNISLVTQ KKARLVCIAI 150
WMFVILTSSP FLMANTYKDE KNNTKCFEPP QDNQAKNYVL ILHYVSLFIG 200
FIIPFITIIV CYTMIIFTLL KSSMKKNLSS RKRAIGMIIV VTAAFLVSFM 250
PYHIQRTIHL HFLHNKTKPC DSILRMQKSV VITLSLAASN CCFDPLLYFF 300
SGGNFRRRLS TIRKYSLSSM TYIPKKKTSL PQKGKDICKE 340
Length:340
Mass (Da):38,984
Last modified:February 7, 2006 - v1
Checksum:iDE544F975FB65F76
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY236968 mRNA. Translation: AAP75558.1.
RefSeqiNP_001166412.1. NM_001172941.2.

Genome annotation databases

EnsembliENSCPOT00000002128; ENSCPOP00000001902; ENSCPOG00000002100.
GeneIDi100135514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY236968 mRNA. Translation: AAP75558.1 .
RefSeqi NP_001166412.1. NM_001172941.2.

3D structure databases

ProteinModelPortali Q2NNR5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10141.ENSCPOP00000001902.

Chemistry

BindingDBi Q2NNR5.
ChEMBLi CHEMBL5645.

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCPOT00000002128 ; ENSCPOP00000001902 ; ENSCPOG00000002100 .
GeneIDi 100135514.

Organism-specific databases

CTDi 10800.

Phylogenomic databases

eggNOGi NOG119185.
GeneTreei ENSGT00750000117402.
HOGENOMi HOG000236328.
HOVERGENi HBG099611.
InParanoidi Q2NNR5.
OMAi PQDNQAK.
OrthoDBi EOG7992R9.
TreeFami TF350009.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR013310. CLT1_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01902. CYSLT1RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and functional characterization of guinea pig cysteinyl leukotriene receptor 1 and 2."
    Ito Y., Nishimura Y., Tanaka T.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCLTR1_CAVPO
AccessioniPrimary (citable) accession number: Q2NNR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: February 7, 2006
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi