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Protein

Cysteinyl leukotriene receptor 1

Gene

CYSLTR1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 1
Short name:
CysLTR1
Alternative name(s):
Cysteinyl leukotriene D4 receptor
Short name:
LTD4 receptor
Gene namesi
Name:CYSLTR1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31ExtracellularSequence analysisAdd BLAST31
Transmembranei32 – 52Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini53 – 60CytoplasmicSequence analysis8
Transmembranei61 – 81Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini82 – 109ExtracellularSequence analysisAdd BLAST28
Transmembranei110 – 130Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini131 – 144CytoplasmicSequence analysisAdd BLAST14
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 196ExtracellularSequence analysisAdd BLAST31
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 233CytoplasmicSequence analysisAdd BLAST16
Transmembranei234 – 254Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini255 – 279ExtracellularSequence analysisAdd BLAST25
Transmembranei280 – 300Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini301 – 340CytoplasmicSequence analysisAdd BLAST40

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5645.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002815731 – 340Cysteinyl leukotriene receptor 1Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 176PROSITE-ProRule annotation
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Gene expression databases

BgeeiENSCPOG00000002100.

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000001902.

Chemistry databases

BindingDBiQ2NNR5.

Structurei

3D structure databases

ProteinModelPortaliQ2NNR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKK2. Eukaryota.
ENOG410XRU6. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ2NNR5.
OMAiPQDNQAK.
OrthoDBiEOG091G0FE0.
TreeFamiTF350009.

Family and domain databases

InterProiView protein in InterPro
IPR013310. CLT1_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR01902. CYSLT1RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2NNR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDETGNPTIP PASNNTCYDS IDDFRNQVYS TLYSMISVVG FFGNGFVLYV
60 70 80 90 100
LVKTYHEKSA FQVYMINLAV ADLLCVCTLP LRVAYYVHKG IWLFGDFLCR
110 120 130 140 150
LSTYALYVNL YCSIFFMTAM SFFRCVAIVF PVQNISLVTQ KKARLVCIAI
160 170 180 190 200
WMFVILTSSP FLMANTYKDE KNNTKCFEPP QDNQAKNYVL ILHYVSLFIG
210 220 230 240 250
FIIPFITIIV CYTMIIFTLL KSSMKKNLSS RKRAIGMIIV VTAAFLVSFM
260 270 280 290 300
PYHIQRTIHL HFLHNKTKPC DSILRMQKSV VITLSLAASN CCFDPLLYFF
310 320 330 340
SGGNFRRRLS TIRKYSLSSM TYIPKKKTSL PQKGKDICKE
Length:340
Mass (Da):38,984
Last modified:February 7, 2006 - v1
Checksum:iDE544F975FB65F76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY236968 mRNA. Translation: AAP75558.1.
RefSeqiNP_001166412.1. NM_001172941.2.

Genome annotation databases

EnsembliENSCPOT00000002128; ENSCPOP00000001902; ENSCPOG00000002100.
GeneIDi100135514.

Similar proteinsi

Entry informationi

Entry nameiCLTR1_CAVPO
AccessioniPrimary (citable) accession number: Q2NNR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: February 7, 2006
Last modified: August 30, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families