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Q2NNR5

- CLTR1_CAVPO

UniProt

Q2NNR5 - CLTR1_CAVPO

Protein

Cysteinyl leukotriene receptor 1

Gene

CYSLTR1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system By similarity.By similarity

    GO - Molecular functioni

    1. leukotriene receptor activity Source: Ensembl

    GO - Biological processi

    1. calcium ion transport Source: Ensembl
    2. chemotaxis Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteinyl leukotriene receptor 1
    Short name:
    CysLTR1
    Alternative name(s):
    Cysteinyl leukotriene D4 receptor
    Short name:
    LTD4 receptor
    Gene namesi
    Name:CYSLTR1
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340Cysteinyl leukotriene receptor 1PRO_0000281573Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi99 ↔ 176PROSITE-ProRule annotation
    Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi10141.ENSCPOP00000001902.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2NNR5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini53 – 608CytoplasmicSequence Analysis
    Topological domaini82 – 10928ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini131 – 14414CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini166 – 19631ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini255 – 27925ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini301 – 34040CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei280 – 30021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG119185.
    GeneTreeiENSGT00750000117402.
    HOGENOMiHOG000236328.
    HOVERGENiHBG099611.
    InParanoidiQ2NNR5.
    OMAiPQDNQAK.
    OrthoDBiEOG7992R9.
    TreeFamiTF350009.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR013310. CLT1_recept.
    IPR004071. Cyst_leuk_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01902. CYSLT1RECPTR.
    PR01533. CYSLTRECPTR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2NNR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDETGNPTIP PASNNTCYDS IDDFRNQVYS TLYSMISVVG FFGNGFVLYV    50
    LVKTYHEKSA FQVYMINLAV ADLLCVCTLP LRVAYYVHKG IWLFGDFLCR 100
    LSTYALYVNL YCSIFFMTAM SFFRCVAIVF PVQNISLVTQ KKARLVCIAI 150
    WMFVILTSSP FLMANTYKDE KNNTKCFEPP QDNQAKNYVL ILHYVSLFIG 200
    FIIPFITIIV CYTMIIFTLL KSSMKKNLSS RKRAIGMIIV VTAAFLVSFM 250
    PYHIQRTIHL HFLHNKTKPC DSILRMQKSV VITLSLAASN CCFDPLLYFF 300
    SGGNFRRRLS TIRKYSLSSM TYIPKKKTSL PQKGKDICKE 340
    Length:340
    Mass (Da):38,984
    Last modified:February 7, 2006 - v1
    Checksum:iDE544F975FB65F76
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY236968 mRNA. Translation: AAP75558.1.
    RefSeqiNP_001166412.1. NM_001172941.2.

    Genome annotation databases

    EnsembliENSCPOT00000002128; ENSCPOP00000001902; ENSCPOG00000002100.
    GeneIDi100135514.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY236968 mRNA. Translation: AAP75558.1 .
    RefSeqi NP_001166412.1. NM_001172941.2.

    3D structure databases

    ProteinModelPortali Q2NNR5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10141.ENSCPOP00000001902.

    Chemistry

    BindingDBi Q2NNR5.
    ChEMBLi CHEMBL5645.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCPOT00000002128 ; ENSCPOP00000001902 ; ENSCPOG00000002100 .
    GeneIDi 100135514.

    Organism-specific databases

    CTDi 10800.

    Phylogenomic databases

    eggNOGi NOG119185.
    GeneTreei ENSGT00750000117402.
    HOGENOMi HOG000236328.
    HOVERGENi HBG099611.
    InParanoidi Q2NNR5.
    OMAi PQDNQAK.
    OrthoDBi EOG7992R9.
    TreeFami TF350009.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR013310. CLT1_recept.
    IPR004071. Cyst_leuk_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01902. CYSLT1RECPTR.
    PR01533. CYSLTRECPTR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional characterization of guinea pig cysteinyl leukotriene receptor 1 and 2."
      Ito Y., Nishimura Y., Tanaka T.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCLTR1_CAVPO
    AccessioniPrimary (citable) accession number: Q2NNR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3