Q2NNR5 (CLTR1_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cysteinyl leukotriene receptor 1
Short name=CysLTR1

Alternative name(s):
Cysteinyl leukotriene D4 receptor
Short name=LTD4 receptor

Gene names

Name:

CYSLTR1

Organism

Cavia porcellus (Guinea pig) [Reference proteome]

Taxonomic identifier

10141 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	calcium ion transport Inferred from electronic annotation. Source: Compara chemotaxis Inferred from electronic annotation. Source: Compara
Cellular_component	integral to plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	leukotriene receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	Cysteinyl leukotriene receptor 1		PRO_0000281573
Regions
	Topological domain	1 – 31	31	Extracellular Potential
	Transmembrane	32 – 52	21	Helical; Name=1; Potential
	Topological domain	53 – 60	8	Cytoplasmic Potential
	Transmembrane	61 – 81	21	Helical; Name=2; Potential
	Topological domain	82 – 109	28	Extracellular Potential
	Transmembrane	110 – 130	21	Helical; Name=3; Potential
	Topological domain	131 – 144	14	Cytoplasmic Potential
	Transmembrane	145 – 165	21	Helical; Name=4; Potential
	Topological domain	166 – 196	31	Extracellular Potential
	Transmembrane	197 – 217	21	Helical; Name=5; Potential
	Topological domain	218 – 233	16	Cytoplasmic Potential
	Transmembrane	234 – 254	21	Helical; Name=6; Potential
	Topological domain	255 – 279	25	Extracellular Potential
	Transmembrane	280 – 300	21	Helical; Name=7; Potential
	Topological domain	301 – 340	40	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	14	1	N-linked (GlcNAc...) Potential
	Glycosylation	172	1	N-linked (GlcNAc...) Potential
	Glycosylation	265	1	N-linked (GlcNAc...) Potential
	Disulfide bond	99 ↔ 176		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2NNR5 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: DE544F975FB65F76	FASTA	340	38,984
	10 20 30 40 50 60 MDETGNPTIP PASNNTCYDS IDDFRNQVYS TLYSMISVVG FFGNGFVLYV LVKTYHEKSA 70 80 90 100 110 120 FQVYMINLAV ADLLCVCTLP LRVAYYVHKG IWLFGDFLCR LSTYALYVNL YCSIFFMTAM 130 140 150 160 170 180 SFFRCVAIVF PVQNISLVTQ KKARLVCIAI WMFVILTSSP FLMANTYKDE KNNTKCFEPP 190 200 210 220 230 240 QDNQAKNYVL ILHYVSLFIG FIIPFITIIV CYTMIIFTLL KSSMKKNLSS RKRAIGMIIV 250 260 270 280 290 300 VTAAFLVSFM PYHIQRTIHL HFLHNKTKPC DSILRMQKSV VITLSLAASN CCFDPLLYFF 310 320 330 340 SGGNFRRRLS TIRKYSLSSM TYIPKKKTSL PQKGKDICKE

References

[1]	"Molecular cloning and functional characterization of guinea pig cysteinyl leukotriene receptor 1 and 2." Ito Y., Nishimura Y., Tanaka T. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY236968 mRNA. Translation: AAP75558.1.
RefSeq	NP_001166412.1. NM_001172941.2.
3D structure databases
ProteinModelPortal	Q2NNR5.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSCPOT00000002128; ENSCPOP00000001902; ENSCPOG00000002100.
GeneID	100135514.
Organism-specific databases
CTD	10800.
Phylogenomic databases
eggNOG	NOG119185.
GeneTree	ENSGT00680000099512.
HOGENOM	HOG000236328.
HOVERGEN	HBG099611.
InParanoid	Q2NNR5.
OMA	LCRISSY.
OrthoDB	EOG46T31Z.
Family and domain databases
InterPro	IPR013310. CLT1_recept. IPR004071. Cyst_leuk_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01902. CYSLT1RECPTR. PR01533. CYSLTRECPTR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q2NNR5.
ChEMBL	CHEMBL5645.

Entry information

Entry name

CLTR1_CAVPO

Accession

Primary (citable) accession number: Q2NNR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	February 7, 2006
Last modified:	March 6, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program