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Protein

Cysteinyl leukotriene receptor 1

Gene

CYSLTR1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

  1. leukotriene receptor activity Source: Ensembl

GO - Biological processi

  1. calcium ion transport Source: Ensembl
  2. chemotaxis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 1
Short name:
CysLTR1
Alternative name(s):
Cysteinyl leukotriene D4 receptor
Short name:
LTD4 receptor
Gene namesi
Name:CYSLTR1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
BLAST
Transmembranei32 – 5221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini53 – 608CytoplasmicSequence Analysis
Transmembranei61 – 8121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini82 – 10928ExtracellularSequence AnalysisAdd
BLAST
Transmembranei110 – 13021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini131 – 14414CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini166 – 19631ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 23316CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei234 – 25421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini255 – 27925ExtracellularSequence AnalysisAdd
BLAST
Transmembranei280 – 30021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini301 – 34040CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Cysteinyl leukotriene receptor 1PRO_0000281573Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 176PROSITE-ProRule annotation
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000001902.

Structurei

3D structure databases

ProteinModelPortaliQ2NNR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG119185.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ2NNR5.
OMAiPQDNQAK.
OrthoDBiEOG7992R9.
TreeFamiTF350009.

Family and domain databases

InterProiIPR013310. CLT1_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01902. CYSLT1RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2NNR5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDETGNPTIP PASNNTCYDS IDDFRNQVYS TLYSMISVVG FFGNGFVLYV
60 70 80 90 100
LVKTYHEKSA FQVYMINLAV ADLLCVCTLP LRVAYYVHKG IWLFGDFLCR
110 120 130 140 150
LSTYALYVNL YCSIFFMTAM SFFRCVAIVF PVQNISLVTQ KKARLVCIAI
160 170 180 190 200
WMFVILTSSP FLMANTYKDE KNNTKCFEPP QDNQAKNYVL ILHYVSLFIG
210 220 230 240 250
FIIPFITIIV CYTMIIFTLL KSSMKKNLSS RKRAIGMIIV VTAAFLVSFM
260 270 280 290 300
PYHIQRTIHL HFLHNKTKPC DSILRMQKSV VITLSLAASN CCFDPLLYFF
310 320 330 340
SGGNFRRRLS TIRKYSLSSM TYIPKKKTSL PQKGKDICKE
Length:340
Mass (Da):38,984
Last modified:February 7, 2006 - v1
Checksum:iDE544F975FB65F76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY236968 mRNA. Translation: AAP75558.1.
RefSeqiNP_001166412.1. NM_001172941.2.

Genome annotation databases

EnsembliENSCPOT00000002128; ENSCPOP00000001902; ENSCPOG00000002100.
GeneIDi100135514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY236968 mRNA. Translation: AAP75558.1.
RefSeqiNP_001166412.1. NM_001172941.2.

3D structure databases

ProteinModelPortaliQ2NNR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000001902.

Chemistry

BindingDBiQ2NNR5.
ChEMBLiCHEMBL5645.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000002128; ENSCPOP00000001902; ENSCPOG00000002100.
GeneIDi100135514.

Organism-specific databases

CTDi10800.

Phylogenomic databases

eggNOGiNOG119185.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ2NNR5.
OMAiPQDNQAK.
OrthoDBiEOG7992R9.
TreeFamiTF350009.

Family and domain databases

InterProiIPR013310. CLT1_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01902. CYSLT1RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and functional characterization of guinea pig cysteinyl leukotriene receptor 1 and 2."
    Ito Y., Nishimura Y., Tanaka T.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCLTR1_CAVPO
AccessioniPrimary (citable) accession number: Q2NNR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: February 7, 2006
Last modified: January 7, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.