ID   VMAC_HUMAN              Reviewed;         169 AA.
AC   Q2NL98; B3KW55;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   24-JAN-2024, entry version 107.
DE   RecName: Full=Vimentin-type intermediate filament-associated coiled-coil protein;
GN   Name=VMAC;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thymus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Cervix;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q2NL98; Q8N9N5-2: BANP; NbExp=4; IntAct=EBI-2803134, EBI-11524452;
CC       Q2NL98; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-2803134, EBI-2556193;
CC       Q2NL98; P25791-3: LMO2; NbExp=3; IntAct=EBI-2803134, EBI-11959475;
CC       Q2NL98; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-2803134, EBI-11742507;
CC       Q2NL98; P61968: LMO4; NbExp=3; IntAct=EBI-2803134, EBI-2798728;
CC       Q2NL98; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-2803134, EBI-739832;
CC       Q2NL98; Q96IV0: NGLY1; NbExp=3; IntAct=EBI-2803134, EBI-6165879;
CC       Q2NL98; P25786: PSMA1; NbExp=3; IntAct=EBI-2803134, EBI-359352;
CC       Q2NL98; Q7Z5V6-2: SAXO4; NbExp=3; IntAct=EBI-2803134, EBI-12000762;
CC       Q2NL98; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-2803134, EBI-748391;
CC       Q2NL98; Q58EX2: SDK2; NbExp=3; IntAct=EBI-2803134, EBI-2801316;
CC       Q2NL98; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-2803134, EBI-742688;
CC       Q2NL98; Q01664: TFAP4; NbExp=3; IntAct=EBI-2803134, EBI-2514218;
CC       Q2NL98; P24278: ZBTB25; NbExp=3; IntAct=EBI-2803134, EBI-739899;
CC       Q2NL98; Q5BKZ1: ZNF326; NbExp=3; IntAct=EBI-2803134, EBI-2560158;
CC       Q2NL98; P51504: ZNF80; NbExp=3; IntAct=EBI-2803134, EBI-12013828;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Colocalizes with
CC       vimentin-type intermediate filaments. {ECO:0000250}.
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DR   EMBL; AK124162; BAG54017.1; -; mRNA.
DR   EMBL; BC110802; AAI10803.1; -; mRNA.
DR   CCDS; CCDS32881.1; -.
DR   RefSeq; NP_001017921.1; NM_001017921.3.
DR   AlphaFoldDB; Q2NL98; -.
DR   SMR; Q2NL98; -.
DR   BioGRID; 134697; 22.
DR   IntAct; Q2NL98; 30.
DR   MINT; Q2NL98; -.
DR   STRING; 9606.ENSP00000343348; -.
DR   iPTMnet; Q2NL98; -.
DR   PhosphoSitePlus; Q2NL98; -.
DR   BioMuta; VMAC; -.
DR   DMDM; 121941615; -.
DR   EPD; Q2NL98; -.
DR   jPOST; Q2NL98; -.
DR   MassIVE; Q2NL98; -.
DR   PaxDb; 9606-ENSP00000343348; -.
DR   PeptideAtlas; Q2NL98; -.
DR   ProteomicsDB; 61425; -.
DR   Antibodypedia; 77776; 4 antibodies from 4 providers.
DR   DNASU; 400673; -.
DR   Ensembl; ENST00000339485.4; ENSP00000343348.2; ENSG00000187650.4.
DR   Ensembl; ENST00000709632.1; ENSP00000517810.1; ENSG00000292061.1.
DR   GeneID; 400673; -.
DR   KEGG; hsa:400673; -.
DR   MANE-Select; ENST00000339485.4; ENSP00000343348.2; NM_001017921.4; NP_001017921.1.
DR   UCSC; uc002mds.5; human.
DR   AGR; HGNC:33803; -.
DR   CTD; 400673; -.
DR   DisGeNET; 400673; -.
DR   GeneCards; VMAC; -.
DR   HGNC; HGNC:33803; VMAC.
DR   HPA; ENSG00000187650; Low tissue specificity.
DR   neXtProt; NX_Q2NL98; -.
DR   OpenTargets; ENSG00000187650; -.
DR   PharmGKB; PA165394584; -.
DR   VEuPathDB; HostDB:ENSG00000187650; -.
DR   eggNOG; ENOG502SD5N; Eukaryota.
DR   GeneTree; ENSGT00390000007212; -.
DR   HOGENOM; CLU_136281_0_0_1; -.
DR   InParanoid; Q2NL98; -.
DR   OMA; KICQRRP; -.
DR   OrthoDB; 5354732at2759; -.
DR   PhylomeDB; Q2NL98; -.
DR   TreeFam; TF332566; -.
DR   PathwayCommons; Q2NL98; -.
DR   SignaLink; Q2NL98; -.
DR   BioGRID-ORCS; 400673; 13 hits in 1150 CRISPR screens.
DR   ChiTaRS; VMAC; human.
DR   GenomeRNAi; 400673; -.
DR   Pharos; Q2NL98; Tdark.
DR   PRO; PR:Q2NL98; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q2NL98; Protein.
DR   Bgee; ENSG00000187650; Expressed in primordial germ cell in gonad and 97 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0045098; C:type III intermediate filament; IBA:GO_Central.
PE   1: Evidence at protein level;
KW   Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..169
FT                   /note="Vimentin-type intermediate filament-associated
FT                   coiled-coil protein"
FT                   /id="PRO_0000319066"
FT   REGION          126..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          7..89
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        132..146
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   169 AA;  18348 MW;  9A3DF7957BC3D69A CRC64;
     MSAPPALQIR EANAHLAAVH RRAAELEARL DAAERTVHAQ AERLALHDQQ LRAALDELGR
     AKDREIATLQ EQLMTSEATV HSLQATVHQR DELIRQLQPR AELLQDICRR RPPLAGLLDA
     LAEAERLGPL PASDPGHPPP GGPGPPLDNS TGEEADRDHL QPAVFGTTV
//