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Protein

Vimentin-type intermediate filament-associated coiled-coil protein

Gene

VMAC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-31302-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Vimentin-type intermediate filament-associated coiled-coil protein
Gene namesi
Name:VMAC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:33803. VMAC.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Colocalizes with vimentin-type intermediate filaments.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187650.
PharmGKBiPA165394584.

Polymorphism and mutation databases

BioMutaiVMAC.
DMDMi121941615.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003190661 – 169Vimentin-type intermediate filament-associated coiled-coil proteinAdd BLAST169

Proteomic databases

PaxDbiQ2NL98.
PeptideAtlasiQ2NL98.
PRIDEiQ2NL98.

PTM databases

iPTMnetiQ2NL98.
PhosphoSitePlusiQ2NL98.

Miscellaneous databases

PMAP-CutDBQ2NL98.

Expressioni

Gene expression databases

BgeeiENSG00000187650.

Interactioni

Protein-protein interaction databases

BioGridi134697. 3 interactors.
IntActiQ2NL98. 26 interactors.
STRINGi9606.ENSP00000343348.

Structurei

3D structure databases

ProteinModelPortaliQ2NL98.
SMRiQ2NL98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili7 – 89Sequence analysisAdd BLAST83

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IWFQ. Eukaryota.
ENOG4111J8G. LUCA.
GeneTreeiENSGT00390000007212.
HOGENOMiHOG000154823.
HOVERGENiHBG097729.
InParanoidiQ2NL98.
OMAiCEIAALQ.
OrthoDBiEOG091G0PGW.
PhylomeDBiQ2NL98.
TreeFamiTF332566.

Sequencei

Sequence statusi: Complete.

Q2NL98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPPALQIR EANAHLAAVH RRAAELEARL DAAERTVHAQ AERLALHDQQ
60 70 80 90 100
LRAALDELGR AKDREIATLQ EQLMTSEATV HSLQATVHQR DELIRQLQPR
110 120 130 140 150
AELLQDICRR RPPLAGLLDA LAEAERLGPL PASDPGHPPP GGPGPPLDNS
160
TGEEADRDHL QPAVFGTTV
Length:169
Mass (Da):18,348
Last modified:February 7, 2006 - v1
Checksum:i9A3DF7957BC3D69A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124162 mRNA. Translation: BAG54017.1.
BC110802 mRNA. Translation: AAI10803.1.
CCDSiCCDS32881.1.
RefSeqiNP_001017921.1. NM_001017921.3.
UniGeneiHs.620821.

Genome annotation databases

EnsembliENST00000339485; ENSP00000343348; ENSG00000187650.
GeneIDi400673.
KEGGihsa:400673.
UCSCiuc002mds.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124162 mRNA. Translation: BAG54017.1.
BC110802 mRNA. Translation: AAI10803.1.
CCDSiCCDS32881.1.
RefSeqiNP_001017921.1. NM_001017921.3.
UniGeneiHs.620821.

3D structure databases

ProteinModelPortaliQ2NL98.
SMRiQ2NL98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134697. 3 interactors.
IntActiQ2NL98. 26 interactors.
STRINGi9606.ENSP00000343348.

PTM databases

iPTMnetiQ2NL98.
PhosphoSitePlusiQ2NL98.

Polymorphism and mutation databases

BioMutaiVMAC.
DMDMi121941615.

Proteomic databases

PaxDbiQ2NL98.
PeptideAtlasiQ2NL98.
PRIDEiQ2NL98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339485; ENSP00000343348; ENSG00000187650.
GeneIDi400673.
KEGGihsa:400673.
UCSCiuc002mds.5. human.

Organism-specific databases

CTDi400673.
GeneCardsiVMAC.
HGNCiHGNC:33803. VMAC.
neXtProtiNX_Q2NL98.
OpenTargetsiENSG00000187650.
PharmGKBiPA165394584.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWFQ. Eukaryota.
ENOG4111J8G. LUCA.
GeneTreeiENSGT00390000007212.
HOGENOMiHOG000154823.
HOVERGENiHBG097729.
InParanoidiQ2NL98.
OMAiCEIAALQ.
OrthoDBiEOG091G0PGW.
PhylomeDBiQ2NL98.
TreeFamiTF332566.

Enzyme and pathway databases

BioCyciZFISH:G66-31302-MONOMER.

Miscellaneous databases

GenomeRNAii400673.
PMAP-CutDBQ2NL98.
PROiQ2NL98.

Gene expression databases

BgeeiENSG00000187650.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiVMAC_HUMAN
AccessioniPrimary (citable) accession number: Q2NL98
Secondary accession number(s): B3KW55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 7, 2006
Last modified: November 30, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.