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Protein

Pre-rRNA-processing protein TSR1 homolog

Gene

TSR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required during maturation of the 40S ribosomal subunit in the nucleolus.By similarity

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: GO_Central
  • poly(A) RNA binding Source: UniProtKB
  • U3 snoRNA binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Enzyme and pathway databases

ReactomeiR-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-rRNA-processing protein TSR1 homolog
Gene namesi
Name:TSR1
Synonyms:KIAA1401
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:25542. TSR1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55720.
OpenTargetsiENSG00000167721.
PharmGKBiPA142670691.

Polymorphism and mutation databases

BioMutaiTSR1.
DMDMi121948971.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003112741 – 804Pre-rRNA-processing protein TSR1 homologAdd BLAST804

Proteomic databases

EPDiQ2NL82.
MaxQBiQ2NL82.
PaxDbiQ2NL82.
PeptideAtlasiQ2NL82.
PRIDEiQ2NL82.

PTM databases

iPTMnetiQ2NL82.
PhosphoSitePlusiQ2NL82.

Miscellaneous databases

PMAP-CutDBQ2NL82.

Expressioni

Gene expression databases

BgeeiENSG00000167721.
CleanExiHS_TSR1.
ExpressionAtlasiQ2NL82. baseline and differential.
GenevisibleiQ2NL82. HS.

Organism-specific databases

HPAiHPA024434.
HPA053087.

Interactioni

Protein-protein interaction databases

BioGridi120842. 117 interactors.
IntActiQ2NL82. 25 interactors.
MINTiMINT-4860330.
STRINGi9606.ENSP00000301364.

Structurei

3D structure databases

ProteinModelPortaliQ2NL82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 248Bms1-type GAdd BLAST168

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi415 – 487Glu-richAdd BLAST73

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1980. Eukaryota.
COG5177. LUCA.
GeneTreeiENSGT00550000074945.
HOGENOMiHOG000165026.
HOVERGENiHBG099515.
InParanoidiQ2NL82.
KOiK14799.
OMAiCGYRRFV.
OrthoDBiEOG091G02Z1.
PhylomeDBiQ2NL82.
TreeFamiTF105717.

Family and domain databases

InterProiIPR012948. AARP2CN.
IPR007034. BMS1_TSR1_C.
IPR030387. G_Bms1/Tsr1_dom.
[Graphical view]
PfamiPF08142. AARP2CN. 1 hit.
PF04950. RIBIOP_C. 1 hit.
[Graphical view]
SMARTiSM00785. AARP2CN. 1 hit.
SM01362. DUF663. 1 hit.
[Graphical view]
PROSITEiPS51714. G_BMS1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2NL82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAHRPGPLK QQNKAHKGGR HRGRGSAQRD GKGRLALKTL SKKVRKELSR
60 70 80 90 100
VDQRHRASQL RKQKKEAVLA EKRQLGGKDG PPHQVLVVPL HSRISLPEAM
110 120 130 140 150
QLLQDRDTGT VHLNELGNTQ NFMLLCPRLK HRWFFTSARP GDLHVVLDMA
160 170 180 190 200
KVADTILFLL DPLEGWDSTG DYCLSCLFAQ GLPTYTLAVQ GISGLPLKKQ
210 220 230 240 250
IDTRKKLSKA VEKRFPHDKL LLLDTQQEAG MLLRQLANQK QQHLAFRDRR
260 270 280 290 300
AYLFAHAVDF VPSEENNLVG TLKISGYVRG QTLNVNRLLH IVGYGDFQMK
310 320 330 340 350
QIDAPGDPFP LNPRGIKPQK DPDMAMEICA TDAVDDMEEG LKVLMKADPG
360 370 380 390 400
RQESLQAEVI PDPMEGEQTW PTEEELSEAK DFLKESSKVV KKVPKGTSSY
410 420 430 440 450
QAEWILDGGS QSGGEGDEYE YDDMEHEDFM EEESQDESSE EEEEYETMTI
460 470 480 490 500
GESVHDDLYD KKVDEEAEAK MLEKYKQERL EEMFPDEVDT PRDVAARIRF
510 520 530 540 550
QKYRGLKSFR TSPWDPKENL PQDYARIFQF QNFTNTRKSI FKEVEEKEVE
560 570 580 590 600
GAEVGWYVTL HVSEVPVSVV ECFRQGTPLI AFSLLPHEQK MSVLNMVVRR
610 620 630 640 650
DPGNTEPVKA KEELIFHCGF RRFRASPLFS QHTAADKHKL QRFLTADMAL
660 670 680 690 700
VATVYAPITF PPASVLLFKQ KSNGMHSLIA TGHLMSVDPD RMVIKRVVLS
710 720 730 740 750
GHPFKIFTKM AVVRYMFFNR EDVLWFKPVE LRTKWGRRGH IKEPLGTHGH
760 770 780 790 800
MKCSFDGKLK SQDTVLMNLY KRVFPKWTYD PYVPEPVPWL KSEISSTVPQ

GGME
Length:804
Mass (Da):91,810
Last modified:February 7, 2006 - v1
Checksum:iEDDBE6AD04E7F3A7
GO

Sequence cautioni

The sequence BAA91667 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA92639 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti350G → C in BAA91667 (PubMed:14702039).Curated1
Sequence conflicti737R → W in BAA92639 (PubMed:10718198).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037211386S → G.1 PublicationCorresponds to variant rs2281726dbSNPEnsembl.1
Natural variantiVAR_037212719N → S.Corresponds to variant rs2273983dbSNPEnsembl.1
Natural variantiVAR_037213727K → Q.Corresponds to variant rs35019711dbSNPEnsembl.1
Natural variantiVAR_037214750H → Q.Corresponds to variant rs35343613dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037822 mRNA. Translation: BAA92639.1. Different initiation.
CH471108 Genomic DNA. Translation: EAW90552.1.
BC019090 mRNA. Translation: AAH19090.2.
BC110851 mRNA. Translation: AAI10852.1.
BC126110 mRNA. Translation: AAI26111.1.
AK001396 mRNA. Translation: BAA91667.1. Different initiation.
CCDSiCCDS32525.1.
RefSeqiNP_060598.3. NM_018128.4.
UniGeneiHs.388170.

Genome annotation databases

EnsembliENST00000301364; ENSP00000301364; ENSG00000167721.
GeneIDi55720.
KEGGihsa:55720.
UCSCiuc002fuj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037822 mRNA. Translation: BAA92639.1. Different initiation.
CH471108 Genomic DNA. Translation: EAW90552.1.
BC019090 mRNA. Translation: AAH19090.2.
BC110851 mRNA. Translation: AAI10852.1.
BC126110 mRNA. Translation: AAI26111.1.
AK001396 mRNA. Translation: BAA91667.1. Different initiation.
CCDSiCCDS32525.1.
RefSeqiNP_060598.3. NM_018128.4.
UniGeneiHs.388170.

3D structure databases

ProteinModelPortaliQ2NL82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120842. 117 interactors.
IntActiQ2NL82. 25 interactors.
MINTiMINT-4860330.
STRINGi9606.ENSP00000301364.

PTM databases

iPTMnetiQ2NL82.
PhosphoSitePlusiQ2NL82.

Polymorphism and mutation databases

BioMutaiTSR1.
DMDMi121948971.

Proteomic databases

EPDiQ2NL82.
MaxQBiQ2NL82.
PaxDbiQ2NL82.
PeptideAtlasiQ2NL82.
PRIDEiQ2NL82.

Protocols and materials databases

DNASUi55720.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301364; ENSP00000301364; ENSG00000167721.
GeneIDi55720.
KEGGihsa:55720.
UCSCiuc002fuj.4. human.

Organism-specific databases

CTDi55720.
DisGeNETi55720.
GeneCardsiTSR1.
HGNCiHGNC:25542. TSR1.
HPAiHPA024434.
HPA053087.
MIMi611214. gene.
neXtProtiNX_Q2NL82.
OpenTargetsiENSG00000167721.
PharmGKBiPA142670691.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1980. Eukaryota.
COG5177. LUCA.
GeneTreeiENSGT00550000074945.
HOGENOMiHOG000165026.
HOVERGENiHBG099515.
InParanoidiQ2NL82.
KOiK14799.
OMAiCGYRRFV.
OrthoDBiEOG091G02Z1.
PhylomeDBiQ2NL82.
TreeFamiTF105717.

Enzyme and pathway databases

ReactomeiR-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

GenomeRNAii55720.
PMAP-CutDBQ2NL82.
PROiQ2NL82.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167721.
CleanExiHS_TSR1.
ExpressionAtlasiQ2NL82. baseline and differential.
GenevisibleiQ2NL82. HS.

Family and domain databases

InterProiIPR012948. AARP2CN.
IPR007034. BMS1_TSR1_C.
IPR030387. G_Bms1/Tsr1_dom.
[Graphical view]
PfamiPF08142. AARP2CN. 1 hit.
PF04950. RIBIOP_C. 1 hit.
[Graphical view]
SMARTiSM00785. AARP2CN. 1 hit.
SM01362. DUF663. 1 hit.
[Graphical view]
PROSITEiPS51714. G_BMS1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSR1_HUMAN
AccessioniPrimary (citable) accession number: Q2NL82
Secondary accession number(s): Q8WUY5, Q9NVT0, Q9P2E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: February 7, 2006
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.