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Q2NL67 (PARP6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Poly [ADP-ribose] polymerase 6

Short name=PARP-6
EC=2.4.2.30
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 17
Short name=ARTD17
Gene names
Name:PARP6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length630 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Sequence similarities

Contains 1 PARP catalytic domain.

Sequence caution

The sequence BAB14969.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAB59261.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   LigandNAD
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmetabolic process

Inferred from electronic annotation. Source: GOC

   Molecular_functionNAD+ ADP-ribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q2NL67-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q2NL67-2)

The sequence of this isoform differs from the canonical sequence as follows:
     498-518: LHGAAYGKGIYLSPISSISFG → EWEKDSTGCPPRMSWSRDTTG
     519-630: Missing.
Isoform 3 (identifier: Q2NL67-3)

The sequence of this isoform differs from the canonical sequence as follows:
     373-388: NPKKKNYERLQKALDS → MVELDPRTTPHSDGPD
     389-630: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 630630Poly [ADP-ribose] polymerase 6
PRO_0000252430

Regions

Domain394 – 620227PARP catalytic

Natural variations

Alternative sequence373 – 38816NPKKK…KALDS → MVELDPRTTPHSDGPD in isoform 3.
VSP_020963
Alternative sequence389 – 630242Missing in isoform 3.
VSP_020964
Alternative sequence498 – 51821LHGAA…SISFG → EWEKDSTGCPPRMSWSRDTT G in isoform 2.
VSP_020965
Alternative sequence519 – 630112Missing in isoform 2.
VSP_020966

Experimental info

Sequence conflict291S → N in BAB14092. Ref.1
Sequence conflict2641E → G in BAB13896. Ref.1
Sequence conflict3881S → N in BAB14969. Ref.1
Sequence conflict4361R → RQ in BAB14092. Ref.1
Sequence conflict4361R → RQ in CAB98250. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 5762F55F59AA9873

FASTA63071,115
        10         20         30         40         50         60 
MDIKGQFWND DDSEGDNESE EFLYGVQGSC AADLYRHPQL DADIEAVKEI YSENSVSIRE 

        70         80         90        100        110        120 
YGTIDDVDID LHINISFLDE EVSTAWKVLR TEPIVLRLRF SLSQYLDGPE PSIEVFQPSN 

       130        140        150        160        170        180 
KEGFGLGLQL KKILGMFTSQ QWKHLSNDFL KTQQEKRHSW FKASGTIKKF RAGLSIFSPI 

       190        200        210        220        230        240 
PKSPSFPIIQ DSMLKGKLGV PELRVGRLMN RSISCTMKNP KVEVFGYPPS PQAGLLCPQH 

       250        260        270        280        290        300 
VGLPPPARTS PLVSGHCKNI PTLEYGFLVQ IMKYAEQRIP TLNEYCVVCD EQHVFQNGSM 

       310        320        330        340        350        360 
LKPAVCTREL CVFSFYTLGV MSGAAEEVAT GAEVVDLLVA MCRAALESPR KSIIFEPYPS 

       370        380        390        400        410        420 
VVDPTDPKTL AFNPKKKNYE RLQKALDSVM SIREMTQGSY LEIKKQMDKL DPLAHPLLQW 

       430        440        450        460        470        480 
IISSNRSHIV KLPLSRLKFM HTSHQFLLLS SPPAKEARFR TAKKLYGSTF AFHGSHIENW 

       490        500        510        520        530        540 
HSILRNGLVN ASYTKLQLHG AAYGKGIYLS PISSISFGYS GMGKGQHRMP SKDELVQRYN 

       550        560        570        580        590        600 
RMNTIPQTRS IQSRFLQSRN LNCIALCEVI TSKDLQKHGN IWVCPVSDHV CTRFFFVYED 

       610        620        630 
GQVGDANINT QDPKIQKEIM RVIGTQVYTN 

« Hide

Isoform 2 [UniParc].

Checksum: ADE86E3EC4A1EAF8
Show »

FASTA51858,483
Isoform 3 [UniParc].

Checksum: EC93A6A029417B01
Show »

FASTA38843,328

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Coronary artery, Embryo and Teratocarcinoma.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: PNS.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-630 (ISOFORM 1).
Tissue: Kidney.
[4]The European IMAGE consortium
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 362-630 (ISOFORM 2).
[5]"Toward a unified nomenclature for mammalian ADP-ribosyltransferases."
Hottiger M.O., Hassa P.O., Luscher B., Schuler H., Koch-Nolte F.
Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK021790 mRNA. Translation: BAB13896.1.
AK022547 mRNA. Translation: BAB14092.1.
AK024703 mRNA. Translation: BAB14969.1. Different initiation.
BC110902 mRNA. Translation: AAI10903.1.
AL122091 mRNA. Translation: CAB59261.1. Different initiation.
AL390093 mRNA. Translation: CAB98250.1.
PIRT34522.
RefSeqNP_064599.2. NM_020214.2.
UniGeneHs.270244.

3D structure databases

ProteinModelPortalQ2NL67.
SMRQ2NL67. Positions 320-600.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121286. 12 interactions.
STRING9606.ENSP00000287196.

PTM databases

PhosphoSiteQ2NL67.

Polymorphism databases

DMDM116248567.

Proteomic databases

PaxDbQ2NL67.
PRIDEQ2NL67.

Protocols and materials databases

DNASU56965.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000260376; ENSP00000260376; ENSG00000137817. [Q2NL67-2]
ENST00000287196; ENSP00000287196; ENSG00000137817. [Q2NL67-1]
ENST00000569795; ENSP00000456348; ENSG00000137817. [Q2NL67-1]
GeneID56965.
KEGGhsa:56965.
UCSCuc002auc.3. human. [Q2NL67-1]

Organism-specific databases

CTD56965.
GeneCardsGC15M072533.
HGNCHGNC:26921. PARP6.
HPAHPA026991.
neXtProtNX_Q2NL67.
PharmGKBPA134900863.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40570.
HOGENOMHOG000115451.
HOVERGENHBG057572.
InParanoidQ2NL67.
KOK15258.
OMAGGHCKNI.
OrthoDBEOG7CRTP4.
TreeFamTF323413.

Enzyme and pathway databases

BRENDA2.4.2.30. 2681.

Gene expression databases

ArrayExpressQ2NL67.
BgeeQ2NL67.
CleanExHS_PARP6.
GenevestigatorQ2NL67.

Family and domain databases

Gene3D3.90.228.10. 2 hits.
InterProIPR012317. Poly(ADP-ribose)pol_cat_dom.
[Graphical view]
PfamPF00644. PARP. 1 hit.
[Graphical view]
PROSITEPS51059. PARP_CATALYTIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPARP6. human.
GenomeRNAi56965.
NextBio62602.
PROQ2NL67.

Entry information

Entry namePARP6_HUMAN
AccessionPrimary (citable) accession number: Q2NL67
Secondary accession number(s): Q9H7C5 expand/collapse secondary AC list , Q9H9X6, Q9HAF3, Q9NPS6, Q9UFG4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: February 7, 2006
Last modified: March 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM