Q2NL67 (PARP6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Poly [ADP-ribose] polymerase 6
Short name=PARP-6
EC=2.4.2.30

Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 17
Short name=ARTD17

Gene names

Name:

PARP6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	630 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
Sequence similarities	Contains 1 PARP catalytic domain.
Sequence caution	The sequence BAB14969.1 differs from that shown. Reason: Erroneous initiation. The sequence CAB59261.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	NAD
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	NAD+ ADP-ribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q2NL67-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q2NL67-2)

The sequence of this isoform differs from the canonical sequence as follows:
     498-518: LHGAAYGKGIYLSPISSISFG → EWEKDSTGCPPRMSWSRDTTG
     519-630: Missing.

Isoform 3 (identifier: Q2NL67-3)

The sequence of this isoform differs from the canonical sequence as follows:
     373-388: NPKKKNYERLQKALDS → MVELDPRTTPHSDGPD
     389-630: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 630	630	Poly [ADP-ribose] polymerase 6		PRO_0000252430
Regions
	Domain	394 – 620	227	PARP catalytic
Natural variations
	Alternative sequence	373 – 388	16	NPKKK…KALDS → MVELDPRTTPHSDGPD in isoform 3.		VSP_020963
	Alternative sequence	389 – 630	242	Missing in isoform 3.		VSP_020964
	Alternative sequence	498 – 518	21	LHGAA…SISFG → EWEKDSTGCPPRMSWSRDTT G in isoform 2.		VSP_020965
	Alternative sequence	519 – 630	112	Missing in isoform 2.		VSP_020966
Experimental info
	Sequence conflict	29	1	S → N in BAB14092. Ref.1
	Sequence conflict	264	1	E → G in BAB13896. Ref.1
	Sequence conflict	388	1	S → N in BAB14969. Ref.1
	Sequence conflict	436	1	R → RQ in BAB14092. Ref.1
	Sequence conflict	436	1	R → RQ in CAB98250. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 5762F55F59AA9873	FASTA	630	71,115
	10 20 30 40 50 60 MDIKGQFWND DDSEGDNESE EFLYGVQGSC AADLYRHPQL DADIEAVKEI YSENSVSIRE 70 80 90 100 110 120 YGTIDDVDID LHINISFLDE EVSTAWKVLR TEPIVLRLRF SLSQYLDGPE PSIEVFQPSN 130 140 150 160 170 180 KEGFGLGLQL KKILGMFTSQ QWKHLSNDFL KTQQEKRHSW FKASGTIKKF RAGLSIFSPI 190 200 210 220 230 240 PKSPSFPIIQ DSMLKGKLGV PELRVGRLMN RSISCTMKNP KVEVFGYPPS PQAGLLCPQH 250 260 270 280 290 300 VGLPPPARTS PLVSGHCKNI PTLEYGFLVQ IMKYAEQRIP TLNEYCVVCD EQHVFQNGSM 310 320 330 340 350 360 LKPAVCTREL CVFSFYTLGV MSGAAEEVAT GAEVVDLLVA MCRAALESPR KSIIFEPYPS 370 380 390 400 410 420 VVDPTDPKTL AFNPKKKNYE RLQKALDSVM SIREMTQGSY LEIKKQMDKL DPLAHPLLQW 430 440 450 460 470 480 IISSNRSHIV KLPLSRLKFM HTSHQFLLLS SPPAKEARFR TAKKLYGSTF AFHGSHIENW 490 500 510 520 530 540 HSILRNGLVN ASYTKLQLHG AAYGKGIYLS PISSISFGYS GMGKGQHRMP SKDELVQRYN 550 560 570 580 590 600 RMNTIPQTRS IQSRFLQSRN LNCIALCEVI TSKDLQKHGN IWVCPVSDHV CTRFFFVYED 610 620 630 GQVGDANINT QDPKIQKEIM RVIGTQVYTN
	Isoform 2 [UniParc]. Checksum: ADE86E3EC4A1EAF8	FASTA	518	58,483
	10 20 30 40 50 60 MDIKGQFWND DDSEGDNESE EFLYGVQGSC AADLYRHPQL DADIEAVKEI YSENSVSIRE 70 80 90 100 110 120 YGTIDDVDID LHINISFLDE EVSTAWKVLR TEPIVLRLRF SLSQYLDGPE PSIEVFQPSN 130 140 150 160 170 180 KEGFGLGLQL KKILGMFTSQ QWKHLSNDFL KTQQEKRHSW FKASGTIKKF RAGLSIFSPI 190 200 210 220 230 240 PKSPSFPIIQ DSMLKGKLGV PELRVGRLMN RSISCTMKNP KVEVFGYPPS PQAGLLCPQH 250 260 270 280 290 300 VGLPPPARTS PLVSGHCKNI PTLEYGFLVQ IMKYAEQRIP TLNEYCVVCD EQHVFQNGSM 310 320 330 340 350 360 LKPAVCTREL CVFSFYTLGV MSGAAEEVAT GAEVVDLLVA MCRAALESPR KSIIFEPYPS 370 380 390 400 410 420 VVDPTDPKTL AFNPKKKNYE RLQKALDSVM SIREMTQGSY LEIKKQMDKL DPLAHPLLQW 430 440 450 460 470 480 IISSNRSHIV KLPLSRLKFM HTSHQFLLLS SPPAKEARFR TAKKLYGSTF AFHGSHIENW 490 500 510 HSILRNGLVN ASYTKLQEWE KDSTGCPPRM SWSRDTTG
	Isoform 3 [UniParc]. Checksum: EC93A6A029417B01	FASTA	388	43,328
	10 20 30 40 50 60 MDIKGQFWND DDSEGDNESE EFLYGVQGSC AADLYRHPQL DADIEAVKEI YSENSVSIRE 70 80 90 100 110 120 YGTIDDVDID LHINISFLDE EVSTAWKVLR TEPIVLRLRF SLSQYLDGPE PSIEVFQPSN 130 140 150 160 170 180 KEGFGLGLQL KKILGMFTSQ QWKHLSNDFL KTQQEKRHSW FKASGTIKKF RAGLSIFSPI 190 200 210 220 230 240 PKSPSFPIIQ DSMLKGKLGV PELRVGRLMN RSISCTMKNP KVEVFGYPPS PQAGLLCPQH 250 260 270 280 290 300 VGLPPPARTS PLVSGHCKNI PTLEYGFLVQ IMKYAEQRIP TLNEYCVVCD EQHVFQNGSM 310 320 330 340 350 360 LKPAVCTREL CVFSFYTLGV MSGAAEEVAT GAEVVDLLVA MCRAALESPR KSIIFEPYPS 370 380 VVDPTDPKTL AFMVELDPRT TPHSDGPD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Coronary artery, Embryo and Teratocarcinoma.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: PNS.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-630 (ISOFORM 1). Tissue: Kidney.
[4]	The European IMAGE consortium Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 362-630 (ISOFORM 2).
[5]	"Toward a unified nomenclature for mammalian ADP-ribosyltransferases." Hottiger M.O., Hassa P.O., Luscher B., Schuler H., Koch-Nolte F. Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK021790 mRNA. Translation: BAB13896.1. AK022547 mRNA. Translation: BAB14092.1. AK024703 mRNA. Translation: BAB14969.1. Different initiation. BC110902 mRNA. Translation: AAI10903.1. AL122091 mRNA. Translation: CAB59261.1. Different initiation. AL390093 mRNA. Translation: CAB98250.1.
IPI	IPI00156933. IPI00790056. IPI00796582.
PIR	T34522.
RefSeq	NP_064599.2. NM_020214.2.
UniGene	Hs.270244.
3D structure databases
ProteinModelPortal	Q2NL67.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000287196.
PTM databases
PhosphoSite	Q2NL67.
Polymorphism databases
DMDM	116248567.
Proteomic databases
PaxDb	Q2NL67.
PRIDE	Q2NL67.
Protocols and materials databases
DNASU	56965.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000260376; ENSP00000260376; ENSG00000137817. ENST00000287196; ENSP00000287196; ENSG00000137817. ENST00000569795; ENSP00000456348; ENSG00000137817.
GeneID	56965.
KEGG	hsa:56965.
UCSC	uc002auc.3. human.
Organism-specific databases
CTD	56965.
GeneCards	GC15M072533.
HGNC	HGNC:26921. PARP6.
HPA	HPA026991.
neXtProt	NX_Q2NL67.
PharmGKB	PA134900863.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40570.
HOGENOM	HOG000115451.
HOVERGEN	HBG057572.
InParanoid	Q2NL67.
KO	K15258.
OMA	GGHCKNI.
OrthoDB	EOG4DBTD8.
Enzyme and pathway databases
BRENDA	2.4.2.30. 2681.
Gene expression databases
ArrayExpress	Q2NL67.
Bgee	Q2NL67.
CleanEx	HS_PARP6.
Genevestigator	Q2NL67.
GermOnline	ENSG00000137817. Homo sapiens.
Family and domain databases
InterPro	IPR012317. Poly(ADP-ribose)pol_cat_dom. [Graphical view]
Pfam	PF00644. PARP. 1 hit. [Graphical view]
PROSITE	PS51059. PARP_CATALYTIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PARP6. human.
GenomeRNAi	56965.
NextBio	62602.

Entry information

Entry name

PARP6_HUMAN

Accession

Primary (citable) accession number: Q2NL67
Secondary accession number(s): Q9H7C5 , Q9H9X6, Q9HAF3, Q9NPS6, Q9UFG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	February 7, 2006
Last modified:	May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.