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Q2NL67

- PARP6_HUMAN

UniProt

Q2NL67 - PARP6_HUMAN

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Protein

Poly [ADP-ribose] polymerase 6

Gene

PARP6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

GO - Molecular functioni

  1. NAD+ ADP-ribosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi2.4.2.30. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 6 (EC:2.4.2.30)
Short name:
PARP-6
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 17
Short name:
ARTD17
Gene namesi
Name:PARP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:26921. PARP6.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134900863.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 630630Poly [ADP-ribose] polymerase 6PRO_0000252430Add
BLAST

Proteomic databases

PaxDbiQ2NL67.
PRIDEiQ2NL67.

PTM databases

PhosphoSiteiQ2NL67.

Expressioni

Gene expression databases

BgeeiQ2NL67.
CleanExiHS_PARP6.
ExpressionAtlasiQ2NL67. baseline and differential.
GenevestigatoriQ2NL67.

Organism-specific databases

HPAiHPA026991.

Interactioni

Protein-protein interaction databases

BioGridi121286. 12 interactions.
STRINGi9606.ENSP00000287196.

Structurei

3D structure databases

ProteinModelPortaliQ2NL67.
SMRiQ2NL67. Positions 321-574.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini394 – 620227PARP catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PARP catalytic domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG40570.
GeneTreeiENSGT00390000017707.
HOGENOMiHOG000115451.
HOVERGENiHBG057572.
InParanoidiQ2NL67.
KOiK15258.
OMAiGGHCKNI.
OrthoDBiEOG7CRTP4.
PhylomeDBiQ2NL67.
TreeFamiTF323413.

Family and domain databases

Gene3Di3.90.228.10. 2 hits.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q2NL67-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDIKGQFWND DDSEGDNESE EFLYGVQGSC AADLYRHPQL DADIEAVKEI
60 70 80 90 100
YSENSVSIRE YGTIDDVDID LHINISFLDE EVSTAWKVLR TEPIVLRLRF
110 120 130 140 150
SLSQYLDGPE PSIEVFQPSN KEGFGLGLQL KKILGMFTSQ QWKHLSNDFL
160 170 180 190 200
KTQQEKRHSW FKASGTIKKF RAGLSIFSPI PKSPSFPIIQ DSMLKGKLGV
210 220 230 240 250
PELRVGRLMN RSISCTMKNP KVEVFGYPPS PQAGLLCPQH VGLPPPARTS
260 270 280 290 300
PLVSGHCKNI PTLEYGFLVQ IMKYAEQRIP TLNEYCVVCD EQHVFQNGSM
310 320 330 340 350
LKPAVCTREL CVFSFYTLGV MSGAAEEVAT GAEVVDLLVA MCRAALESPR
360 370 380 390 400
KSIIFEPYPS VVDPTDPKTL AFNPKKKNYE RLQKALDSVM SIREMTQGSY
410 420 430 440 450
LEIKKQMDKL DPLAHPLLQW IISSNRSHIV KLPLSRLKFM HTSHQFLLLS
460 470 480 490 500
SPPAKEARFR TAKKLYGSTF AFHGSHIENW HSILRNGLVN ASYTKLQLHG
510 520 530 540 550
AAYGKGIYLS PISSISFGYS GMGKGQHRMP SKDELVQRYN RMNTIPQTRS
560 570 580 590 600
IQSRFLQSRN LNCIALCEVI TSKDLQKHGN IWVCPVSDHV CTRFFFVYED
610 620 630
GQVGDANINT QDPKIQKEIM RVIGTQVYTN
Length:630
Mass (Da):71,115
Last modified:February 7, 2006 - v1
Checksum:i5762F55F59AA9873
GO
Isoform 2 (identifier: Q2NL67-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     498-518: LHGAAYGKGIYLSPISSISFG → EWEKDSTGCPPRMSWSRDTTG
     519-630: Missing.

Show »
Length:518
Mass (Da):58,483
Checksum:iADE86E3EC4A1EAF8
GO
Isoform 3 (identifier: Q2NL67-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     373-388: NPKKKNYERLQKALDS → MVELDPRTTPHSDGPD
     389-630: Missing.

Note: No experimental confirmation available.

Show »
Length:388
Mass (Da):43,328
Checksum:iEC93A6A029417B01
GO

Sequence cautioni

The sequence BAB14969.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAB59261.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291S → N in BAB14092. (PubMed:14702039)Curated
Sequence conflicti264 – 2641E → G in BAB13896. (PubMed:14702039)Curated
Sequence conflicti388 – 3881S → N in BAB14969. (PubMed:14702039)Curated
Sequence conflicti436 – 4361R → RQ in BAB14092. (PubMed:14702039)Curated
Sequence conflicti436 – 4361R → RQ in CAB98250. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei373 – 38816NPKKK…KALDS → MVELDPRTTPHSDGPD in isoform 3. 1 PublicationVSP_020963Add
BLAST
Alternative sequencei389 – 630242Missing in isoform 3. 1 PublicationVSP_020964Add
BLAST
Alternative sequencei498 – 51821LHGAA…SISFG → EWEKDSTGCPPRMSWSRDTT G in isoform 2. 2 PublicationsVSP_020965Add
BLAST
Alternative sequencei519 – 630112Missing in isoform 2. 2 PublicationsVSP_020966Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021790 mRNA. Translation: BAB13896.1.
AK022547 mRNA. Translation: BAB14092.1.
AK024703 mRNA. Translation: BAB14969.1. Different initiation.
BC110902 mRNA. Translation: AAI10903.1.
AL122091 mRNA. Translation: CAB59261.1. Different initiation.
AL390093 mRNA. Translation: CAB98250.1.
CCDSiCCDS10241.2. [Q2NL67-1]
PIRiT34522.
RefSeqiNP_064599.2. NM_020214.2. [Q2NL67-1]
UniGeneiHs.270244.

Genome annotation databases

EnsembliENST00000260376; ENSP00000260376; ENSG00000137817. [Q2NL67-2]
ENST00000287196; ENSP00000287196; ENSG00000137817. [Q2NL67-1]
ENST00000569795; ENSP00000456348; ENSG00000137817. [Q2NL67-1]
GeneIDi56965.
KEGGihsa:56965.
UCSCiuc002auc.3. human. [Q2NL67-1]

Polymorphism databases

DMDMi116248567.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021790 mRNA. Translation: BAB13896.1 .
AK022547 mRNA. Translation: BAB14092.1 .
AK024703 mRNA. Translation: BAB14969.1 . Different initiation.
BC110902 mRNA. Translation: AAI10903.1 .
AL122091 mRNA. Translation: CAB59261.1 . Different initiation.
AL390093 mRNA. Translation: CAB98250.1 .
CCDSi CCDS10241.2. [Q2NL67-1 ]
PIRi T34522.
RefSeqi NP_064599.2. NM_020214.2. [Q2NL67-1 ]
UniGenei Hs.270244.

3D structure databases

ProteinModelPortali Q2NL67.
SMRi Q2NL67. Positions 321-574.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121286. 12 interactions.
STRINGi 9606.ENSP00000287196.

Chemistry

BindingDBi Q2NL67.
ChEMBLi CHEMBL2380187.

PTM databases

PhosphoSitei Q2NL67.

Polymorphism databases

DMDMi 116248567.

Proteomic databases

PaxDbi Q2NL67.
PRIDEi Q2NL67.

Protocols and materials databases

DNASUi 56965.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000260376 ; ENSP00000260376 ; ENSG00000137817 . [Q2NL67-2 ]
ENST00000287196 ; ENSP00000287196 ; ENSG00000137817 . [Q2NL67-1 ]
ENST00000569795 ; ENSP00000456348 ; ENSG00000137817 . [Q2NL67-1 ]
GeneIDi 56965.
KEGGi hsa:56965.
UCSCi uc002auc.3. human. [Q2NL67-1 ]

Organism-specific databases

CTDi 56965.
GeneCardsi GC15M072533.
HGNCi HGNC:26921. PARP6.
HPAi HPA026991.
neXtProti NX_Q2NL67.
PharmGKBi PA134900863.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40570.
GeneTreei ENSGT00390000017707.
HOGENOMi HOG000115451.
HOVERGENi HBG057572.
InParanoidi Q2NL67.
KOi K15258.
OMAi GGHCKNI.
OrthoDBi EOG7CRTP4.
PhylomeDBi Q2NL67.
TreeFami TF323413.

Enzyme and pathway databases

BRENDAi 2.4.2.30. 2681.

Miscellaneous databases

ChiTaRSi PARP6. human.
GenomeRNAii 56965.
NextBioi 62602.
PROi Q2NL67.

Gene expression databases

Bgeei Q2NL67.
CleanExi HS_PARP6.
ExpressionAtlasi Q2NL67. baseline and differential.
Genevestigatori Q2NL67.

Family and domain databases

Gene3Di 3.90.228.10. 2 hits.
InterProi IPR012317. Poly(ADP-ribose)pol_cat_dom.
[Graphical view ]
Pfami PF00644. PARP. 1 hit.
[Graphical view ]
PROSITEi PS51059. PARP_CATALYTIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Coronary artery, Embryo and Teratocarcinoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: PNS.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-630 (ISOFORM 1).
    Tissue: Kidney.
  4. The European IMAGE consortium
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 362-630 (ISOFORM 2).
  5. "Toward a unified nomenclature for mammalian ADP-ribosyltransferases."
    Hottiger M.O., Hassa P.O., Luscher B., Schuler H., Koch-Nolte F.
    Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiPARP6_HUMAN
AccessioniPrimary (citable) accession number: Q2NL67
Secondary accession number(s): Q9H7C5
, Q9H9X6, Q9HAF3, Q9NPS6, Q9UFG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: February 7, 2006
Last modified: November 26, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3