Reviewed,
UniProtKB/Swiss-Prot Q2NL67 (PARP6_HUMAN)
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November 3, 2009.
Version 37.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Poly [ADP-ribose] polymerase 6 Short name=PARP-6 EC=2.4.2.30 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 630 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. |
| Sequence similarities | Contains 1 PARP catalytic domain. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Ligand | NAD |
| Molecular function | Glycosyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | nucleus Inferred from electronic annotation. Source: InterPro |
| Molecular function | NAD+ ADP-ribosyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q2NL67-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q2NL67-2) The sequence of this isoform differs from the canonical sequence as follows: 498-518: LHGAAYGKGIYLSPISSISFG → EWEKDSTGCPPRMSWSRDTTG 519-630: Missing. | ||||||
| Isoform 3 (identifier: Q2NL67-3) The sequence of this isoform differs from the canonical sequence as follows: 373-388: NPKKKNYERLQKALDS → MVELDPRTTPHSDGPD 389-630: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 630 | 630 | Poly [ADP-ribose] polymerase 6 | PRO_0000252430 | |||||
Regions | |||||||||
| Domain | 394 – 620 | 227 | PARP catalytic | ||||||
Natural variations | |||||||||
| Alternative sequence | 373 – 388 | 16 | NPKKK…KALDS → MVELDPRTTPHSDGPD in isoform 3. | VSP_020963 | |||||
| Alternative sequence | 389 – 630 | 242 | Missing in isoform 3. | VSP_020964 | |||||
| Alternative sequence | 498 – 518 | 21 | LHGAA…SISFG → EWEKDSTGCPPRMSWSRDTT G in isoform 2. | VSP_020965 | |||||
| Alternative sequence | 519 – 630 | 112 | Missing in isoform 2. | VSP_020966 | |||||
Experimental info | |||||||||
| Sequence conflict | 29 | 1 | S → N in BAB14092. Ref.1 | ||||||
| Sequence conflict | 264 | 1 | E → G in BAB13896. Ref.1 | ||||||
| Sequence conflict | 388 | 1 | S → N in BAB14969. Ref.1 | ||||||
| Sequence conflict | 436 | 1 | R → RQ in BAB14092. Ref.1 | ||||||
| Sequence conflict | 436 | 1 | R → RQ in CAB98250. Ref.4 | ||||||
Sequences
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References
| [1] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.  Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Coronary artery, Embryo and Teratocarcinoma. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: PNS. |
| [3] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-630 (ISOFORM 1). Tissue: Kidney. |
| [4] | The European IMAGE consortium Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 362-630 (ISOFORM 2). |
Cross-references
Sequence databases | |
|---|---|
| AK021790 mRNA. Translation: BAB13896.1. AK022547 mRNA. Translation: BAB14092.1. AK024703 mRNA. Translation: BAB14969.1. Different initiation. BC110902 mRNA. Translation: AAI10903.1. AL122091 mRNA. Translation: CAB59261.1. Different initiation. AL390093 mRNA. Translation: CAB98250.1. | |
| IPI | IPI00156933. IPI00790056. IPI00796582. |
| PIR | T34522. |
| RefSeq | NP_064599.2. |
| UniGene | Hs.270244 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q2NL67. |
Proteomic databases | |
| PRIDE | Q2NL67. |
Genome annotation databases | |
| Ensembl | ENST00000260376; ENSP00000260376; ENSG00000137817; Homo sapiens. [Genome view] ENST00000287196; ENSP00000287196; ENSG00000137817; Homo sapiens. [Genome view] ENST00000336471; ENSP00000338599; ENSG00000137817; Homo sapiens. [Genome view] ENST00000413097; ENSP00000388919; ENSG00000137817; Homo sapiens. [Genome view] |
| GeneID | 56965. |
| KEGG | hsa:56965. |
| UCSC | uc002auc.1. human. |
Organism-specific databases | |
| CTD | 56965. |
| GeneCards | GC15M070320. |
| HGNC | HGNC:26921. PARP6. |
| HPA | HPA026991. |
| PharmGKB | PA134900863. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q2NL67. |
| OMA | CTVKNPK. |
Enzyme and pathway databases | |
| BRENDA | 2.4.2.30. 247. |
Gene expression databases | |
| ArrayExpress | Q2NL67. |
| Bgee | Q2NL67. |
| CleanEx | HS_PARP6. |
| Genevestigator | Q2NL67. |
| GermOnline | ENSG00000137817. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR012317. PARP_catalytic. [Graphical view] |
| Pfam | PF00644. PARP. 1 hit. [Graphical view] |
| PROSITE | PS51059. PARP_CATALYTIC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 62602. |
Entry information
| Entry name | PARP6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q2NL67 Secondary accession number(s): Q9H7C5 Q9UFG4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 15 Human chromosome 15: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |
