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Q2NL67

- PARP6_HUMAN

UniProt

Q2NL67 - PARP6_HUMAN

Protein

Poly [ADP-ribose] polymerase 6

Gene

PARP6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. NAD+ ADP-ribosyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BRENDAi2.4.2.30. 2681.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly [ADP-ribose] polymerase 6 (EC:2.4.2.30)
    Short name:
    PARP-6
    Alternative name(s):
    ADP-ribosyltransferase diphtheria toxin-like 17
    Short name:
    ARTD17
    Gene namesi
    Name:PARP6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:26921. PARP6.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134900863.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 630630Poly [ADP-ribose] polymerase 6PRO_0000252430Add
    BLAST

    Proteomic databases

    PaxDbiQ2NL67.
    PRIDEiQ2NL67.

    PTM databases

    PhosphoSiteiQ2NL67.

    Expressioni

    Gene expression databases

    ArrayExpressiQ2NL67.
    BgeeiQ2NL67.
    CleanExiHS_PARP6.
    GenevestigatoriQ2NL67.

    Organism-specific databases

    HPAiHPA026991.

    Interactioni

    Protein-protein interaction databases

    BioGridi121286. 12 interactions.
    STRINGi9606.ENSP00000287196.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2NL67.
    SMRiQ2NL67. Positions 321-574.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini394 – 620227PARP catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PARP catalytic domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG40570.
    HOGENOMiHOG000115451.
    HOVERGENiHBG057572.
    InParanoidiQ2NL67.
    KOiK15258.
    OMAiGGHCKNI.
    OrthoDBiEOG7CRTP4.
    PhylomeDBiQ2NL67.
    TreeFamiTF323413.

    Family and domain databases

    Gene3Di3.90.228.10. 2 hits.
    InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
    [Graphical view]
    PfamiPF00644. PARP. 1 hit.
    [Graphical view]
    PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q2NL67-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDIKGQFWND DDSEGDNESE EFLYGVQGSC AADLYRHPQL DADIEAVKEI    50
    YSENSVSIRE YGTIDDVDID LHINISFLDE EVSTAWKVLR TEPIVLRLRF 100
    SLSQYLDGPE PSIEVFQPSN KEGFGLGLQL KKILGMFTSQ QWKHLSNDFL 150
    KTQQEKRHSW FKASGTIKKF RAGLSIFSPI PKSPSFPIIQ DSMLKGKLGV 200
    PELRVGRLMN RSISCTMKNP KVEVFGYPPS PQAGLLCPQH VGLPPPARTS 250
    PLVSGHCKNI PTLEYGFLVQ IMKYAEQRIP TLNEYCVVCD EQHVFQNGSM 300
    LKPAVCTREL CVFSFYTLGV MSGAAEEVAT GAEVVDLLVA MCRAALESPR 350
    KSIIFEPYPS VVDPTDPKTL AFNPKKKNYE RLQKALDSVM SIREMTQGSY 400
    LEIKKQMDKL DPLAHPLLQW IISSNRSHIV KLPLSRLKFM HTSHQFLLLS 450
    SPPAKEARFR TAKKLYGSTF AFHGSHIENW HSILRNGLVN ASYTKLQLHG 500
    AAYGKGIYLS PISSISFGYS GMGKGQHRMP SKDELVQRYN RMNTIPQTRS 550
    IQSRFLQSRN LNCIALCEVI TSKDLQKHGN IWVCPVSDHV CTRFFFVYED 600
    GQVGDANINT QDPKIQKEIM RVIGTQVYTN 630
    Length:630
    Mass (Da):71,115
    Last modified:February 7, 2006 - v1
    Checksum:i5762F55F59AA9873
    GO
    Isoform 2 (identifier: Q2NL67-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         498-518: LHGAAYGKGIYLSPISSISFG → EWEKDSTGCPPRMSWSRDTTG
         519-630: Missing.

    Show »
    Length:518
    Mass (Da):58,483
    Checksum:iADE86E3EC4A1EAF8
    GO
    Isoform 3 (identifier: Q2NL67-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         373-388: NPKKKNYERLQKALDS → MVELDPRTTPHSDGPD
         389-630: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:388
    Mass (Da):43,328
    Checksum:iEC93A6A029417B01
    GO

    Sequence cautioni

    The sequence BAB14969.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAB59261.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti29 – 291S → N in BAB14092. (PubMed:14702039)Curated
    Sequence conflicti264 – 2641E → G in BAB13896. (PubMed:14702039)Curated
    Sequence conflicti388 – 3881S → N in BAB14969. (PubMed:14702039)Curated
    Sequence conflicti436 – 4361R → RQ in BAB14092. (PubMed:14702039)Curated
    Sequence conflicti436 – 4361R → RQ in CAB98250. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei373 – 38816NPKKK…KALDS → MVELDPRTTPHSDGPD in isoform 3. 1 PublicationVSP_020963Add
    BLAST
    Alternative sequencei389 – 630242Missing in isoform 3. 1 PublicationVSP_020964Add
    BLAST
    Alternative sequencei498 – 51821LHGAA…SISFG → EWEKDSTGCPPRMSWSRDTT G in isoform 2. 2 PublicationsVSP_020965Add
    BLAST
    Alternative sequencei519 – 630112Missing in isoform 2. 2 PublicationsVSP_020966Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK021790 mRNA. Translation: BAB13896.1.
    AK022547 mRNA. Translation: BAB14092.1.
    AK024703 mRNA. Translation: BAB14969.1. Different initiation.
    BC110902 mRNA. Translation: AAI10903.1.
    AL122091 mRNA. Translation: CAB59261.1. Different initiation.
    AL390093 mRNA. Translation: CAB98250.1.
    CCDSiCCDS10241.2. [Q2NL67-1]
    PIRiT34522.
    RefSeqiNP_064599.2. NM_020214.2. [Q2NL67-1]
    UniGeneiHs.270244.

    Genome annotation databases

    EnsembliENST00000260376; ENSP00000260376; ENSG00000137817. [Q2NL67-2]
    ENST00000287196; ENSP00000287196; ENSG00000137817. [Q2NL67-1]
    ENST00000569795; ENSP00000456348; ENSG00000137817. [Q2NL67-1]
    GeneIDi56965.
    KEGGihsa:56965.
    UCSCiuc002auc.3. human. [Q2NL67-1]

    Polymorphism databases

    DMDMi116248567.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK021790 mRNA. Translation: BAB13896.1 .
    AK022547 mRNA. Translation: BAB14092.1 .
    AK024703 mRNA. Translation: BAB14969.1 . Different initiation.
    BC110902 mRNA. Translation: AAI10903.1 .
    AL122091 mRNA. Translation: CAB59261.1 . Different initiation.
    AL390093 mRNA. Translation: CAB98250.1 .
    CCDSi CCDS10241.2. [Q2NL67-1 ]
    PIRi T34522.
    RefSeqi NP_064599.2. NM_020214.2. [Q2NL67-1 ]
    UniGenei Hs.270244.

    3D structure databases

    ProteinModelPortali Q2NL67.
    SMRi Q2NL67. Positions 321-574.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121286. 12 interactions.
    STRINGi 9606.ENSP00000287196.

    Chemistry

    ChEMBLi CHEMBL2380187.

    PTM databases

    PhosphoSitei Q2NL67.

    Polymorphism databases

    DMDMi 116248567.

    Proteomic databases

    PaxDbi Q2NL67.
    PRIDEi Q2NL67.

    Protocols and materials databases

    DNASUi 56965.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000260376 ; ENSP00000260376 ; ENSG00000137817 . [Q2NL67-2 ]
    ENST00000287196 ; ENSP00000287196 ; ENSG00000137817 . [Q2NL67-1 ]
    ENST00000569795 ; ENSP00000456348 ; ENSG00000137817 . [Q2NL67-1 ]
    GeneIDi 56965.
    KEGGi hsa:56965.
    UCSCi uc002auc.3. human. [Q2NL67-1 ]

    Organism-specific databases

    CTDi 56965.
    GeneCardsi GC15M072533.
    HGNCi HGNC:26921. PARP6.
    HPAi HPA026991.
    neXtProti NX_Q2NL67.
    PharmGKBi PA134900863.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40570.
    HOGENOMi HOG000115451.
    HOVERGENi HBG057572.
    InParanoidi Q2NL67.
    KOi K15258.
    OMAi GGHCKNI.
    OrthoDBi EOG7CRTP4.
    PhylomeDBi Q2NL67.
    TreeFami TF323413.

    Enzyme and pathway databases

    BRENDAi 2.4.2.30. 2681.

    Miscellaneous databases

    ChiTaRSi PARP6. human.
    GenomeRNAii 56965.
    NextBioi 62602.
    PROi Q2NL67.

    Gene expression databases

    ArrayExpressi Q2NL67.
    Bgeei Q2NL67.
    CleanExi HS_PARP6.
    Genevestigatori Q2NL67.

    Family and domain databases

    Gene3Di 3.90.228.10. 2 hits.
    InterProi IPR012317. Poly(ADP-ribose)pol_cat_dom.
    [Graphical view ]
    Pfami PF00644. PARP. 1 hit.
    [Graphical view ]
    PROSITEi PS51059. PARP_CATALYTIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Coronary artery, Embryo and Teratocarcinoma.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: PNS.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-630 (ISOFORM 1).
      Tissue: Kidney.
    4. The European IMAGE consortium
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 362-630 (ISOFORM 2).
    5. "Toward a unified nomenclature for mammalian ADP-ribosyltransferases."
      Hottiger M.O., Hassa P.O., Luscher B., Schuler H., Koch-Nolte F.
      Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiPARP6_HUMAN
    AccessioniPrimary (citable) accession number: Q2NL67
    Secondary accession number(s): Q9H7C5
    , Q9H9X6, Q9HAF3, Q9NPS6, Q9UFG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3