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Protein

Methylthioribose-1-phosphate isomerase

Gene

MRI1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).UniRule annotation

Catalytic activityi

S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.UniRule annotation

Pathwayi: L-methionine biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Methylthioribose-1-phosphate isomerase (MRI1)
  2. Methylthioribulose-1-phosphate dehydratase (APIP)
  3. Enolase-phosphatase E1 (ENOPH1)
  4. Enolase-phosphatase E1 (ENOPH1)
  5. 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (ADI1)
  6. no protein annotated in this organism
This subpathway is part of the pathway L-methionine biosynthesis via salvage pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate, the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei168Transition state stabilizerUniRule annotation1
Active sitei248Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

ReactomeiR-BTA-1237112 Methionine salvage pathway
UniPathwayiUPA00904; UER00874

Names & Taxonomyi

Protein namesi
Recommended name:
Methylthioribose-1-phosphate isomeraseUniRule annotation (EC:5.3.1.23UniRule annotation)
Short name:
M1PiUniRule annotation
Short name:
MTR-1-P isomeraseUniRule annotation
Alternative name(s):
S-methyl-5-thioribose-1-phosphate isomeraseUniRule annotation
Translation initiation factor eIF-2B subunit alpha/beta/delta-like proteinUniRule annotation
Gene namesi
Name:MRI1UniRule annotation
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:31604 MRI1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003173241 – 358Methylthioribose-1-phosphate isomeraseAdd BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2NL31
PRIDEiQ2NL31

Expressioni

Gene expression databases

BgeeiENSBTAG00000002524

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003273

Structurei

3D structure databases

ProteinModelPortaliQ2NL31
SMRiQ2NL31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1468 Eukaryota
COG0182 LUCA
GeneTreeiENSGT00390000013732
HOGENOMiHOG000224730
InParanoidiQ2NL31
KOiK08963
OMAiVNVLTHC
OrthoDBiEOG091G0BA6
TreeFamiTF300852

Family and domain databases

Gene3Di1.20.120.4201 hit
HAMAPiMF_01678 Salvage_MtnA, 1 hit
InterProiView protein in InterPro
IPR000649 IF-2B-related
IPR005251 IF-M1Pi
IPR011559 Initiation_fac_2B_a/b/d
IPR027363 M1Pi_N
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01008 IF-2B, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR00524 eIF-2B_rel, 1 hit
TIGR00512 salvage_mtnA, 1 hit

Sequencei

Sequence statusi: Complete.

Q2NL31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLEAIRYSR GSLQILDQLL LPQQSRYEAV GSVRQAWEAI RAMKVRGAPA
60 70 80 90 100
IALVGCLSLA VELQAGAGGP GLAALVAFVQ DALSFLVTAR PTAVNMARAA
110 120 130 140 150
RDLADLAAQE AEREGATEEA VRERVICWAE DMLDKDLRDN RSIGDLGAHH
160 170 180 190 200
LLKRAAPQGG KVTVLTHCNT GALATAGYGT ALGVIRSLHN LGRLEHAFCT
210 220 230 240 250
ETRPYNQGAR LTAFELVYEQ IPATLIADSM AAAAMAHQGV SAVVVGADRV
260 270 280 290 300
VANGDTANKV GTYQLAIAAK HHGIPFYVAA PSSSCDLRLE TGREIVIEER
310 320 330 340 350
PDQELTDVNG VRIAAPGIGV WNPAFDVTPH DLITGGIITE LGVFAPEELQ

AALSATIS
Length:358
Mass (Da):37,826
Last modified:February 7, 2006 - v1
Checksum:i7681668544A204BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111154 mRNA Translation: AAI11155.1
RefSeqiNP_001039852.1, NM_001046387.1
UniGeneiBt.10874

Genome annotation databases

EnsembliENSBTAT00000003273; ENSBTAP00000003273; ENSBTAG00000002524
GeneIDi534734
KEGGibta:534734

Similar proteinsi

Entry informationi

Entry nameiMTNA_BOVIN
AccessioniPrimary (citable) accession number: Q2NL31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 7, 2006
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome