Reviewed, UniProtKB/Swiss-Prot Q2NL29 (INO1_BOVIN)

Names and origin

Protein names

Recommended name:
    Inositol-3-phosphate synthase 1
    EC=5.5.1.4
Alternative name(s):
    Myo-inositol-1-phosphate synthase
      Short name=MI-1-P synthase
      Short name=MIP synthase
      Short name=IPS

Gene names

Name:	ISYNA1
Synonyms:	INO1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds By similarity.
Catalytic activity	D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate.
Cofactor	NAD By similarity.
Pathway	Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the myo-inositol-1-phosphate synthase family.

Ontologies

Keywords
Biological process	Inositol biosynthesis Phospholipid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	inositol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro inositol-3-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 557	557	Inositol-3-phosphate synthase 1		PRO_0000324627

Sequences

	Sequence		Length	Mass (Da)
	Q2NL29-1 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: ED36D9C5754C1FDA	FASTA	557	60,761
	10 20 30 40 50 60 MEAATEFVVE SPDVVYSPET IEAQYEYRTT SVSREGGVLK VHPTSTRFTF RTARQVPRLG 70 80 90 100 110 120 VMLVGWGGNN GSTLTAAVLA NRLRLSWPTR TGRKEANYYG SLTQAGTVSL GLDAEGKEVF 130 140 150 160 170 180 VPFSSLLPMV APDDLVFDGW DISSLNLAEA MRRAQVLDWG LQEQLWPHME AMRPRPSVYI 190 200 210 220 230 240 PEFIAANQSA RADNVIPGTR AQQLEQIRRD IRDFRFSAGL DKVIVLWTAN TERFCEVIPG 250 260 270 280 290 300 LNDTAENLLR TIQLGLEVSP STLFAVASIL EGCAFLNGSP QNTLVPGALE LAWQRRVFVG 310 320 330 340 350 360 GDDFKSGQTK VKSVLVDFLI GSGLKTMSIV SYNHLGNNDG QNLSAPPQFR SKEVSKSSVV 370 380 390 400 410 420 DDMVHSNPVL YSPGEQPDHC VVIKYVPYVG DSKRALDEYT SELMLGGTNT LVLHNTCEDS 430 440 450 460 470 480 LLAAPIMLDL ALLTELCQRV SFCTDVDPDP QSFHPVLSLL GFLFKAPLAP PGSPVVNALF 490 500 510 520 530 540 RQRSCIENIL RACVGLPPQN HMLLEHKMER PGLKRVGPLA TTSPVLCKKG SAPTAPNGCT 550 GDANGHSQAE APQMPTT

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC111160 mRNA. Translation: AAI11161.1.
IPI	IPI00707152.
RefSeq	NP_001039497.1.
UniGene	Bt.59123
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000017482. Bos taurus. [Contig view]
GeneID	509394.
KEGG	bta:509394.
Phylogenomic databases
HOVERGEN	Q2NL29.
OMA	Q2NL29. VLYAPGE.
Enzyme and pathway databases
BRENDA	5.5.1.4. 251.
Family and domain databases
InterPro	IPR002587. Myo-inos-1-P_Synthase. IPR013021. Myo-inos-1-P_Synthase_GAPDH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11510. Inos-1-P_synth. 1 hit.
Pfam	PF01658. Inos-1-P_synth. 1 hit. PF07994. NAD_binding_5. 1 hit. [Graphical view]
PIRSF	PIRSF015578. Myoinos-ppht_syn. 1 hit.
ProtoNet	Search...

Entry information

Entry name

INO1_BOVIN

Accession

Primary (citable) accession number: Q2NL29

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	February 7, 2006
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)