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Protein

Kinesin-like protein KIF2A

Gene

KIF2A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi267 – 2748ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Motor protein

Keywords - Biological processi

Cell cycle, Cell division, Differentiation, Mitosis, Neurogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF2A
Gene namesi
Name:KIF2A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 660660Kinesin-like protein KIF2APRO_0000253714Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 481PhosphoserineBy similarity
Modified residuei51 – 511PhosphothreonineBy similarity
Modified residuei70 – 701PhosphothreonineBy similarity
Modified residuei73 – 731PhosphoserineBy similarity
Modified residuei75 – 751N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ2NL05.

Interactioni

Subunit structurei

Interacts with AURKA, PSRC1 and PLK1.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ2NL05.
SMRiQ2NL05. Positions 150-504.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini177 – 507331Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 171171GlobularSequence analysisAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili614 – 65340Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000231329.
HOVERGENiHBG003875.
InParanoidiQ2NL05.
KOiK10393.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2NL05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTSLNEDNE SVTVEWIENG DTKGKEIDLE SIFSLNPDLV PDEDIEPSPE
60 70 80 90 100
TPPPPTSSAK VNKIVKNRRT VASIKNEPPP RDNRVVGSAR ARPSQLPEQS
110 120 130 140 150
SSAQQNARRK SNCVKEVEKL QEKREKRRLQ QQELREKRAQ DVDATNPNYE
160 170 180 190 200
IMCMIRDFRG SLDYRPLTTA DPIDEHRICV CVRKRPLNKK ETQMKDLDVI
210 220 230 240 250
TIPSKDVVMV HEPKQKVDLT RYLENQTFRF DYAFDDSAPN EMVYRFTARP
260 270 280 290 300
LVETIFERGM ATCFAYGQTG SGKTHTMGGD FSGKNQDCSK GIYALAARDV
310 320 330 340 350
FLMLKKPNYK KLELQVNATF FEIYSGKVFD LLNRKTKLRV LEDGKQQVQV
360 370 380 390 400
VGLQEREVKC VEDVLKLIDI GNSCRTSGQT SANAHSSRSH AVFQIILRRK
410 420 430 440 450
GKLHGKFSLI DLAGNERGAD TSSADRQTRL EGAEINKSLL AHKECIRALG
460 470 480 490 500
RNKPHTPFRA SKLTQVLRDS FIGENSRTCM IATISPGMAS CENTLNTLRY
510 520 530 540 550
ANRVKELTVD PTAAGDVRPI MHHPPNQIDD LEAQWGVGSS PQRDDLKLLC
560 570 580 590 600
EQNEEEVSPQ LFTFHEAVSQ MVEMEEQVVE DHRAVFQESI RWLEDEKALL
610 620 630 640 650
EMTEEVDYDV DSYATQLEAI LEQKIDILTE LRDKVKSFRA ALQEEEQASK
660
QINPKRPRAL
Length:660
Mass (Da):74,994
Last modified:February 7, 2006 - v1
Checksum:i4D0143CDFF51361E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111267 mRNA. Translation: AAI11268.1.
RefSeqiNP_001070541.1. NM_001077073.1.
UniGeneiBt.107239.

Genome annotation databases

GeneIDi768014.
KEGGibta:768014.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111267 mRNA. Translation: AAI11268.1.
RefSeqiNP_001070541.1. NM_001077073.1.
UniGeneiBt.107239.

3D structure databases

ProteinModelPortaliQ2NL05.
SMRiQ2NL05. Positions 150-504.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ2NL05.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi768014.
KEGGibta:768014.

Organism-specific databases

CTDi3796.

Phylogenomic databases

HOGENOMiHOG000231329.
HOVERGENiHBG003875.
InParanoidiQ2NL05.
KOiK10393.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKIF2A_BOVIN
AccessioniPrimary (citable) accession number: Q2NL05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: February 7, 2006
Last modified: July 6, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.