ID   GPX8_BOVIN              Reviewed;         209 AA.
AC   Q2NL01;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Probable glutathione peroxidase 8;
DE            EC=1.11.1.9;
GN   Name=GPX8;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 2 glutathione + H(2)O(2) = glutathione
CC       disulfide + 2 H(2)O.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein
CC       (Potential).
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
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DR   EMBL; BC111287; AAI11288.1; -; mRNA.
DR   IPI; IPI00705199; -.
DR   RefSeq; NP_001039553.1; -.
DR   UniGene; Bt.28466; -.
DR   Ensembl; ENSBTAG00000021960; Bos taurus.
DR   GeneID; 511575; -.
DR   KEGG; bta:511575; -.
DR   HOVERGEN; Q2NL01; -.
DR   OMA; Q2NL01; FHFSVLA.
DR   BRENDA; 1.11.1.9; 251.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   InterPro; IPR013376; Glut_perox_Gpx7.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR012335; Thioredoxin_fold.
DR   Gene3D; G3DSA:3.40.30.10; Thioredoxin_fold; 1.
DR   PANTHER; PTHR11592; Glut_peroxidase; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   TIGRFAMs; TIGR02540; gpx7; 1.
DR   PROSITE; PS00460; GLUTATHIONE_PEROXID_1; FALSE_NEG.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Oxidoreductase; Peroxidase; Transmembrane.
FT   CHAIN         1    209       Probable glutathione peroxidase 8.
FT                                /FTId=PRO_0000317755.
FT   TRANSMEM     18     40       Potential.
FT   ACT_SITE     79     79       By similarity.
SQ   SEQUENCE   209 AA;  23983 MW;  3A26DF87DBA34B3B CRC64;
     MEPLTAYPLR CSGPKAKAFA VLLSMVLCTV MLFLLQLKFL KPKINSFYTF EVKDANGRVV
     SLEKFKGKVA LVVNVASDCQ LTDRNYLALQ ELHKEFGPFH FSVLAFPCNQ FGESEPRPSK
     EVVSFARNNF GVTFPIFHKI KILGSEAEPA FRFLVDSSKK EPRWNFWKYL VNPEGQVVKT
     WRPEEPIEVI RPEIAALIRQ MIIKKKEDL
//