Reviewed, UniProtKB/Swiss-Prot Q2NL01 (GPX8_BOVIN)

Names and origin

Protein names

Recommended name:
    Probable glutathione peroxidase 8
    EC=1.11.1.9

Gene names

Name:

GPX8

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
Subcellular location	Membrane; Single-pass membrane proteinPotential.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Probable glutathione peroxidase 8		PRO_0000317755
Regions
	Transmembrane	18 – 40	23	Potential
Sites
	Active site	79	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2NL01-1 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 3A26DF87DBA34B3B	FASTA	209	23,983
	10 20 30 40 50 60 MEPLTAYPLR CSGPKAKAFA VLLSMVLCTV MLFLLQLKFL KPKINSFYTF EVKDANGRVV 70 80 90 100 110 120 SLEKFKGKVA LVVNVASDCQ LTDRNYLALQ ELHKEFGPFH FSVLAFPCNQ FGESEPRPSK 130 140 150 160 170 180 EVVSFARNNF GVTFPIFHKI KILGSEAEPA FRFLVDSSKK EPRWNFWKYL VNPEGQVVKT 190 200 WRPEEPIEVI RPEIAALIRQ MIIKKKEDL

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC111287 mRNA. Translation: AAI11288.1.
RefSeq	NP_001039553.1.
UniGene	Bt.28466
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000021960. Bos taurus. [Contig view]
GeneID	511575.
KEGG	bta:511575.
Phylogenomic databases
HOVERGEN	Q2NL01.
Family and domain databases
InterPro	IPR013376. Glut_perox_Gpx7. IPR000889. Glut_peroxidase. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
TIGRFAMs	TIGR02540. gpx7. 1 hit.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. False negative. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX8_BOVIN

Accession

Primary (citable) accession number: Q2NL01

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 7, 2006
Last modified:	November 25, 2008
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)