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Q2NL00

- GSTT1_BOVIN

UniProt

Q2NL00 - GSTT1_BOVIN

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Protein
Glutathione S-transferase theta-1
Gene
GSTT1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutathione metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_223659. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase theta-1 (EC:2.5.1.18)
Alternative name(s):
GST class-theta-1
Gene namesi
Name:GSTT1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 17

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 240239Glutathione S-transferase theta-1
PRO_0000245031Add
BLAST

Proteomic databases

PRIDEiQ2NL00.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007403.

Structurei

3D structure databases

ProteinModelPortaliQ2NL00.
SMRiQ2NL00. Positions 2-240.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8281GST N-terminal
Add
BLAST
Domaini88 – 226139GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 542Glutathione binding By similarity
Regioni66 – 672Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.

Phylogenomic databases

eggNOGiCOG0625.
GeneTreeiENSGT00540000069741.
HOGENOMiHOG000125747.
HOVERGENiHBG051854.
InParanoidiQ2NL00.
KOiK00799.
OMAiRRNCLRT.
OrthoDBiEOG7GTT59.
TreeFamiTF325759.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2NL00-1 [UniParc]FASTAAdd to Basket

« Hide

MGLELYLDLL SQPCRAIYIF AKKNRIPFEL RTVDLRKGQH LSDAFAQVNP    50
LQKVPILKDG DFILTESVAI LLYLARKYKV PDHWYPQDLQ ACARVDEYLA 100
WQHTALRRNC LRALWHKVML PVFLGEPVSP EMLATTLAEL DMALQVLEGK 150
FLQDKAFLTG SHISLADLVA ITELMHPVGA GCQVFKGRPK LAAWRQRVEA 200
AVGEVLFQEA HEVILKAKDS QPADPTLKQK MLPKVLAMIQ 240
Length:240
Mass (Da):27,149
Last modified:January 23, 2007 - v3
Checksum:iB4128AEAB8785F31
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC111289 mRNA. Translation: AAI11290.1.
RefSeqiNP_001039697.1. NM_001046232.2.
UniGeneiBt.23204.

Genome annotation databases

EnsembliENSBTAT00000007403; ENSBTAP00000007403; ENSBTAG00000040298.
GeneIDi517724.
KEGGibta:517724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC111289 mRNA. Translation: AAI11290.1 .
RefSeqi NP_001039697.1. NM_001046232.2.
UniGenei Bt.23204.

3D structure databases

ProteinModelPortali Q2NL00.
SMRi Q2NL00. Positions 2-240.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000007403.

Proteomic databases

PRIDEi Q2NL00.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000007403 ; ENSBTAP00000007403 ; ENSBTAG00000040298 .
GeneIDi 517724.
KEGGi bta:517724.

Organism-specific databases

CTDi 2952.

Phylogenomic databases

eggNOGi COG0625.
GeneTreei ENSGT00540000069741.
HOGENOMi HOG000125747.
HOVERGENi HBG051854.
InParanoidi Q2NL00.
KOi K00799.
OMAi RRNCLRT.
OrthoDBi EOG7GTT59.
TreeFami TF325759.

Enzyme and pathway databases

Reactomei REACT_223659. Glutathione conjugation.

Miscellaneous databases

NextBioi 20872495.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiGSTT1_BOVIN
AccessioniPrimary (citable) accession number: Q2NL00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 66 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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