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Protein

Glutathione S-transferase theta-1

Gene

GSTT1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase theta-1 (EC:2.5.1.18)
Alternative name(s):
GST class-theta-1
Gene namesi
Name:GSTT1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002450311 – 240Glutathione S-transferase theta-1Add BLAST240

Proteomic databases

PaxDbiQ2NL00.
PRIDEiQ2NL00.

Expressioni

Gene expression databases

BgeeiENSBTAG00000040298.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007403.

Structurei

3D structure databases

ProteinModelPortaliQ2NL00.
SMRiQ2NL00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 82GST N-terminalAdd BLAST81
Domaini88 – 226GST C-terminalAdd BLAST139

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni53 – 54Glutathione bindingBy similarity2
Regioni66 – 67Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
COG0625. LUCA.
GeneTreeiENSGT00540000069741.
HOGENOMiHOG000125747.
HOVERGENiHBG051854.
InParanoidiQ2NL00.
KOiK00799.
OMAiDYWYPQD.
OrthoDBiEOG091G0PCG.
TreeFamiTF325759.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR036282. Glutathione-S-Trfase_C_sf.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR036249. Thioredoxin-like_sf.
PfamiView protein in Pfam
PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2NL00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLELYLDLL SQPCRAIYIF AKKNRIPFEL RTVDLRKGQH LSDAFAQVNP
60 70 80 90 100
LQKVPILKDG DFILTESVAI LLYLARKYKV PDHWYPQDLQ ACARVDEYLA
110 120 130 140 150
WQHTALRRNC LRALWHKVML PVFLGEPVSP EMLATTLAEL DMALQVLEGK
160 170 180 190 200
FLQDKAFLTG SHISLADLVA ITELMHPVGA GCQVFKGRPK LAAWRQRVEA
210 220 230 240
AVGEVLFQEA HEVILKAKDS QPADPTLKQK MLPKVLAMIQ
Length:240
Mass (Da):27,149
Last modified:January 23, 2007 - v3
Checksum:iB4128AEAB8785F31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111289 mRNA. Translation: AAI11290.1.
RefSeqiNP_001039697.1. NM_001046232.2.
UniGeneiBt.23204.

Genome annotation databases

EnsembliENSBTAT00000007403; ENSBTAP00000007403; ENSBTAG00000040298.
GeneIDi517724.
KEGGibta:517724.

Similar proteinsi

Entry informationi

Entry nameiGSTT1_BOVIN
AccessioniPrimary (citable) accession number: Q2NL00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 84 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families