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Q2NL00 (GSTT1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase theta-1

EC=2.5.1.18
Alternative name(s):
GST class-theta-1
Gene names
Name:GSTT1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the GST superfamily. Theta family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutathione metabolic process

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 240239Glutathione S-transferase theta-1
PRO_0000245031

Regions

Domain2 – 8281GST N-terminal
Domain88 – 226139GST C-terminal
Region53 – 542Glutathione binding By similarity
Region66 – 672Glutathione binding By similarity

Sites

Binding site401Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2NL00 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: B4128AEAB8785F31

FASTA24027,149
        10         20         30         40         50         60 
MGLELYLDLL SQPCRAIYIF AKKNRIPFEL RTVDLRKGQH LSDAFAQVNP LQKVPILKDG 

        70         80         90        100        110        120 
DFILTESVAI LLYLARKYKV PDHWYPQDLQ ACARVDEYLA WQHTALRRNC LRALWHKVML 

       130        140        150        160        170        180 
PVFLGEPVSP EMLATTLAEL DMALQVLEGK FLQDKAFLTG SHISLADLVA ITELMHPVGA 

       190        200        210        220        230        240 
GCQVFKGRPK LAAWRQRVEA AVGEVLFQEA HEVILKAKDS QPADPTLKQK MLPKVLAMIQ 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC111289 mRNA. Translation: AAI11290.1.
RefSeqNP_001039697.1. NM_001046232.2.
UniGeneBt.23204.

3D structure databases

ProteinModelPortalQ2NL00.
SMRQ2NL00. Positions 2-240.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000007403.

Proteomic databases

PRIDEQ2NL00.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000007403; ENSBTAP00000007403; ENSBTAG00000040298.
GeneID517724.
KEGGbta:517724.

Organism-specific databases

CTD2952.

Phylogenomic databases

eggNOGCOG0625.
GeneTreeENSGT00540000069741.
HOGENOMHOG000125747.
HOVERGENHBG051854.
InParanoidQ2NL00.
KOK00799.
OMARRNCLRT.
OrthoDBEOG7GTT59.
TreeFamTF325759.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20872495.

Entry information

Entry nameGSTT1_BOVIN
AccessionPrimary (citable) accession number: Q2NL00
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 65 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families