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Protein

T-complex protein 1 subunit eta

Gene

CCT7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit eta
Short name:
TCP-1-eta
Alternative name(s):
CCT-eta
Gene namesi
Name:CCT7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002362641 – 543T-complex protein 1 subunit etaAdd BLAST543

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei67N6-acetyllysineBy similarity1
Modified residuei250N6-acetyllysineBy similarity1
Modified residuei320N6-acetyllysineBy similarity1
Cross-linki430Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei535Omega-N-methylarginineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

PaxDbiQ2NKZ1.
PRIDEiQ2NKZ1.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ2NKZ1.
DIPiDIP-58621N.
IntActiQ2NKZ1. 3 interactors.
STRINGi9913.ENSBTAP00000016954.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IYGelectron microscopy-H10-524[»]
4B2TX-ray5.50H/h1-543[»]
ProteinModelPortaliQ2NKZ1.
SMRiQ2NKZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0360. Eukaryota.
COG0459. LUCA.
HOGENOMiHOG000226730.
HOVERGENiHBG001052.
InParanoidiQ2NKZ1.
KOiK09499.

Family and domain databases

CDDicd03340. TCP1_eta. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
InterProiView protein in InterPro
IPR012720. Chap_CCT_eta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
PANTHERiPTHR11353:SF139. PTHR11353:SF139. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02345. chap_CCT_eta. 1 hit.
PROSITEiView protein in PROSITE
PS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2NKZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPTPVILLK EGTDSSQGIP QLVSNISACQ VIAEAVRTTL GPRGMDKLIV
60 70 80 90 100
DGRGKATISN DGATILKLLD VVHPAAKTLV DIAKSQDAEV GDGTTSVTLL
110 120 130 140 150
AAEFLKQVKP YVEEGLHPQI IIRAFRTATQ LAVNKIKEIA VTVKKEDKVE
160 170 180 190 200
QRKLLEKCAM TALSSKLISQ QKAFFAKMVV DAVMMLDDLL QLKMIGIKKV
210 220 230 240 250
QGGALEESQL VAGVAFKKTF SYAGFEMQPK KYHNPMIALL NVELELKAEK
260 270 280 290 300
DNAEIRVHTV EDYQAIVDAE WNILYDKLEK IHHSGAKVVL SKLPIGDVAT
310 320 330 340 350
QYFADRDMFC AGRVPEEDLK RTMMACGGSI QTSVNALSSD VLGRCQVFEE
360 370 380 390 400
TQIGGERYNF FTGCPKAKTC TIILRGGAEQ FMEETERSLH DAIMIVRRAI
410 420 430 440 450
KNDSVVAGGG AIEMELSKYL RDYSRTIPGK QQLLIGAYAK ALEIIPRQLC
460 470 480 490 500
DNAGFDATNI LNKLRARHAQ GGMWYGVDIN TEDIADNFEA FVWEPAMVRI
510 520 530 540
NALTAASEAA CLIVSVDETI KNPRSTVDAS PAAGRGRGRG RLH
Length:543
Mass (Da):59,443
Last modified:February 7, 2006 - v1
Checksum:iE5367265CFAC03EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111332 mRNA. Translation: AAI11333.1.
RefSeqiNP_001039636.1. NM_001046171.2.
UniGeneiBt.4704.

Genome annotation databases

GeneIDi514355.
KEGGibta:514355.

Similar proteinsi

Entry informationi

Entry nameiTCPH_BOVIN
AccessioniPrimary (citable) accession number: Q2NKZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: February 7, 2006
Last modified: September 27, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families