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Protein

Putative ATP-dependent RNA helicase DHX30

Gene

DHX30

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the assembly of the mitochondrial large ribosomal subunit. Associates with mitochondrial DNA. Required for optimal function of the zinc-finger antiviral protein ZC3HAV1.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi483 – 490ATP8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processRibosome biogenesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ATP-dependent RNA helicase DHX30 (EC:3.6.4.13)
Alternative name(s):
DEAH box protein 30
Gene namesi
Name:DHX30
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Mitochondrion nucleoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002455371 – 1220Putative ATP-dependent RNA helicase DHX30Add BLAST1220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei252PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2NKY8.
PRIDEiQ2NKY8.

Interactioni

Subunit structurei

Identified in a complex with TFAM and SSBP1. Interacts with AGO1 and AGO2 (By similarity). Interacts (via N-terminus) with ZC3HAV1 (via N-terminal domain) in an RNA-independent manner. Found in a complex with GRSF1, DDX28, FASTKD2 and FASTKD5.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000030598.

Structurei

3D structure databases

ProteinModelPortaliQ2NKY8.
SMRiQ2NKY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 147DRBMAdd BLAST69
Domaini470 – 638Helicase ATP-bindingAdd BLAST169
Domaini680 – 853Helicase C-terminalAdd BLAST174

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi585 – 588DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi214 – 225Poly-GluAdd BLAST12

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0920. Eukaryota.
COG1643. LUCA.
HOGENOMiHOG000112212.
HOVERGENiHBG081437.
InParanoidiQ2NKY8.
KOiK13185.

Family and domain databases

CDDicd00079. HELICc. 1 hit.
InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2NKY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATARRLMAL AAGVSPRLRP LGPRAIGRQG GPRGLSTGCS RPDRTQEAAE
60 70 80 90 100
AEAAPGEPGE GDGSVVNASR DLLKEFPQPK NLLNSVIGRA LGISHAKDKL
110 120 130 140 150
VYVHTNGPKK KKVTLHIKWP KSVEVEGYGS KKIDAERQAA AAACQLFKGW
160 170 180 190 200
GLLGPRNELF DAAKYRVLAD RFGSPADSWW RPEPTMPPTS WRQLNPESIR
210 220 230 240 250
PGGPGGLSRS LGREEEEDEE EELEEGTIDV TEFLSMTQQD SHAPLRDSRG
260 270 280 290 300
GSFEMTDDDS AIRALTQFPL PKNLLAKVIQ IATSSSTAKN LMQFHTVGTK
310 320 330 340 350
TKLSTLTLLW PCPMTFVAKG RRKAEAENKA AALACNKLKS LGLVDRNNEP
360 370 380 390 400
LTHAMYNLAS LRELGETQRR PCTIQVPEPI LRKIETFLNH YPVESSWISS
410 420 430 440 450
ELRLQGEDIL PLGKDSGPLS DPITGKPYVP LSEAEELRLS QSLLELWRRR
460 470 480 490 500
GPVWQEAPQL PVDPHRDTIL NAIEQHPVVV IAGDTGCGKT TRIPQLLLER
510 520 530 540 550
YVTEGRGARC NVIITQPRRI SAVSVAQRVS HELGPTLRRN VGFQVRLESK
560 570 580 590 600
PPARGGALLF CTVGILLRKL QSNPSLEGVS HVVVDEEHER DVNTDFLLIL
610 620 630 640 650
LKGLQRLNPA LRLVLMSATG DNERFSRYFG GCPVIKVPGF MYPVKEHYLE
660 670 680 690 700
DILAKLGKHQ YPHRHRHHES EDECALDLDL VTDLVLHIDA RGEPGGILCF
710 720 730 740 750
LPGWQEIKGV QQRLQEALGM HESKYLILPV HSNIPMMDQK AIFQQPPIGV
760 770 780 790 800
RKIVLATNIA ETSITINDIV HVVDSGLHKE ERYDLKTKVS CLETVWVSRA
810 820 830 840 850
NVIQRRGRAG RCQSGFAYHL FPRSRLEKMA PFQVPEILRT PLENLVLQAK
860 870 880 890 900
IHMPEKTAVE FLSKAVDSPN IKAVDEAVIL LQEIGVLDQR EYLTTLGQRL
910 920 930 940 950
AHISTDPRLA KAIVLAAIFR CLHPLLVVVS CLTRDPFSSS LQNRAEVDKV
960 970 980 990 1000
KALLSHDSGS DHLAFVRAVS GWEEVLRWQD RSSRENYLEE NLLYAPSLRF
1010 1020 1030 1040 1050
IHGLIKQFSE NIYEAFLVGK PSDCTLASAQ CNEYSEEEEL VKGVLMAGLY
1060 1070 1080 1090 1100
PNLIQVRQGK VTRQGKFKPN SVTYRTKSGN ILLHKSTINR EATRLRSRWL
1110 1120 1130 1140 1150
TYFMAVKSNG SVFVRDSSQV HPLAVLLLTD GDVHIRDDGR RATISLSDSD
1160 1170 1180 1190 1200
LLRLEGDSRT VRLLRELRRA LGRMVERSLR SELAALPPCV QEEHGQLLAL
1210 1220
LAELLRGPCG SFDVRKTADD
Length:1,220
Mass (Da):135,946
Last modified:February 7, 2006 - v1
Checksum:iDF762DBFF8C3128C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111349 mRNA. Translation: AAI11350.1.
RefSeqiNP_001070003.1. NM_001076535.2.
UniGeneiBt.24588.

Genome annotation databases

GeneIDi767607.
KEGGibta:767607.

Similar proteinsi

Entry informationi

Entry nameiDHX30_BOVIN
AccessioniPrimary (citable) accession number: Q2NKY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: February 7, 2006
Last modified: October 25, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families