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Protein

Leukotriene C4 synthase

Gene

LTC4S

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.

Catalytic activityi

Leukotriene C4 = leukotriene A4 + glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei30GlutathioneBy similarity1
Active sitei31Proton donorBy similarity1
Active sitei104Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processLeukotriene biosynthesis

Enzyme and pathway databases

ReactomeiR-BTA-2142688 Synthesis of 5-eicosatetraenoic acids
R-BTA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-BTA-2142700 Synthesis of Lipoxins (LX)
R-BTA-9026762 Biosynthesis of maresin conjugates in tissue regeneration (MCTR)
R-BTA-9026766 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene C4 synthase (EC:4.4.1.20)
Short name:
LTC4 synthase
Alternative name(s):
Leukotriene-C(4) synthase
Gene namesi
Name:LTC4S
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:31076 LTC4S

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicBy similarity6
Transmembranei7 – 27HelicalBy similarityAdd BLAST21
Topological domaini28 – 48LumenalBy similarityAdd BLAST21
Transmembranei49 – 69HelicalBy similarityAdd BLAST21
Topological domaini70 – 73CytoplasmicBy similarity4
Transmembranei74 – 94HelicalBy similarityAdd BLAST21
Topological domaini95 – 104LumenalBy similarity10
Transmembranei105 – 124HelicalBy similarityAdd BLAST20
Topological domaini125 – 150CytoplasmicBy similarityAdd BLAST26

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003780861 – 150Leukotriene C4 synthaseAdd BLAST150

Proteomic databases

PaxDbiQ2NKS0
PRIDEiQ2NKS0

Expressioni

Gene expression databases

BgeeiENSBTAG00000009737

Interactioni

Subunit structurei

Homotrimer. Interacts with ALOX5AP and ALOX5 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012836

Structurei

3D structure databases

SMRiQ2NKS0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 55Glutathione bindingBy similarity5
Regioni58 – 59Glutathione bindingBy similarity2
Regioni93 – 97Glutathione bindingBy similarity5

Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX5F Eukaryota
ENOG4111JV7 LUCA
GeneTreeiENSGT00430000030964
HOGENOMiHOG000116372
InParanoidiQ2NKS0
KOiK00807
OMAiAGIFFHQ
OrthoDBiEOG091G12NW
TreeFamiTF105328

Family and domain databases

Gene3Di1.20.120.550, 1 hit
InterProiView protein in InterPro
IPR001446 5_LipOase_AP
IPR023352 MAPEG-like_dom_sf
IPR001129 Membr-assoc_MAPEG
PfamiView protein in Pfam
PF01124 MAPEG, 1 hit
PRINTSiPR00488 5LPOXGNASEAP
SUPFAMiSSF161084 SSF161084, 1 hit

Sequencei

Sequence statusi: Complete.

Q2NKS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDEVALLAS VTLLGVLLQA YFSLQVISAR RAFRVSPPLT TGPPEFERIY
60 70 80 90 100
RAQVNCSEYF PLFLAMLWVA GIFFHEGAAA LCGLVYLFAR LRYFQGYARS
110 120 130 140 150
AQQRLAPLYA SARALWLLVA LAALGLLAHF LPAELRAALL GQLRKLLLRS
Length:150
Mass (Da):16,701
Last modified:June 16, 2009 - v2
Checksum:iDF46ADF41C79BA97
GO

Sequence cautioni

The sequence AAI11677 differs from that shown. Reason: Erroneous termination at position 134. Translated as Glu.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111676 mRNA Translation: AAI11677.1 Sequence problems.
DN547943 mRNA No translation available.
RefSeqiNP_001039563.2, NM_001046098.2
UniGeneiBt.35956

Genome annotation databases

EnsembliENSBTAT00000012836; ENSBTAP00000012836; ENSBTAG00000009737
GeneIDi511749
KEGGibta:511749

Similar proteinsi

Entry informationi

Entry nameiLTC4S_BOVIN
AccessioniPrimary (citable) accession number: Q2NKS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 16, 2009
Last modified: May 23, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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