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Protein

Leukotriene C4 synthase

Gene

LTC4S

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.

Catalytic activityi

Leukotriene C4 = leukotriene A4 + glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei30 – 301GlutathioneBy similarity
Active sitei31 – 311Proton donorBy similarity
Active sitei104 – 1041Proton acceptorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Leukotriene biosynthesis

Enzyme and pathway databases

ReactomeiR-BTA-2142688. Synthesis of 5-eicosatetraenoic acids.
R-BTA-2142691. Synthesis of Leukotrienes (LT) and Eoxins (EX).
R-BTA-2142700. Synthesis of Lipoxins (LX).

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene C4 synthase (EC:4.4.1.20)
Short name:
LTC4 synthase
Alternative name(s):
Leukotriene-C(4) synthase
Gene namesi
Name:LTC4S
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicBy similarity
Transmembranei7 – 2721HelicalBy similarityAdd
BLAST
Topological domaini28 – 4821LumenalBy similarityAdd
BLAST
Transmembranei49 – 6921HelicalBy similarityAdd
BLAST
Topological domaini70 – 734CytoplasmicBy similarity
Transmembranei74 – 9421HelicalBy similarityAdd
BLAST
Topological domaini95 – 10410LumenalBy similarity
Transmembranei105 – 12420HelicalBy similarityAdd
BLAST
Topological domaini125 – 15026CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 150150Leukotriene C4 synthasePRO_0000378086Add
BLAST

Proteomic databases

PaxDbiQ2NKS0.

Interactioni

Subunit structurei

Homotrimer. Interacts with ALOX5AP and ALOX5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012836.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 555Glutathione bindingBy similarity
Regioni58 – 592Glutathione bindingBy similarity
Regioni93 – 975Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX5F. Eukaryota.
ENOG4111JV7. LUCA.
GeneTreeiENSGT00430000030964.
HOGENOMiHOG000116372.
InParanoidiQ2NKS0.
KOiK00807.
OMAiIFRAQAN.
OrthoDBiEOG7GXPD5.
TreeFamiTF105328.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR001446. 5_LipOase_AP.
IPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]
PRINTSiPR00488. 5LPOXGNASEAP.

Sequencei

Sequence statusi: Complete.

Q2NKS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDEVALLAS VTLLGVLLQA YFSLQVISAR RAFRVSPPLT TGPPEFERIY
60 70 80 90 100
RAQVNCSEYF PLFLAMLWVA GIFFHEGAAA LCGLVYLFAR LRYFQGYARS
110 120 130 140 150
AQQRLAPLYA SARALWLLVA LAALGLLAHF LPAELRAALL GQLRKLLLRS
Length:150
Mass (Da):16,701
Last modified:June 16, 2009 - v2
Checksum:iDF46ADF41C79BA97
GO

Sequence cautioni

The sequence AAI11677.1 differs from that shown. Reason: Erroneous termination at position 134. Translated as Glu.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111676 mRNA. Translation: AAI11677.1. Sequence problems.
DN547943 mRNA. No translation available.
RefSeqiNP_001039563.2. NM_001046098.2.
UniGeneiBt.35956.

Genome annotation databases

EnsembliENSBTAT00000012836; ENSBTAP00000012836; ENSBTAG00000009737.
GeneIDi511749.
KEGGibta:511749.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111676 mRNA. Translation: AAI11677.1. Sequence problems.
DN547943 mRNA. No translation available.
RefSeqiNP_001039563.2. NM_001046098.2.
UniGeneiBt.35956.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012836.

Proteomic databases

PaxDbiQ2NKS0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000012836; ENSBTAP00000012836; ENSBTAG00000009737.
GeneIDi511749.
KEGGibta:511749.

Organism-specific databases

CTDi4056.

Phylogenomic databases

eggNOGiENOG410IX5F. Eukaryota.
ENOG4111JV7. LUCA.
GeneTreeiENSGT00430000030964.
HOGENOMiHOG000116372.
InParanoidiQ2NKS0.
KOiK00807.
OMAiIFRAQAN.
OrthoDBiEOG7GXPD5.
TreeFamiTF105328.

Enzyme and pathway databases

ReactomeiR-BTA-2142688. Synthesis of 5-eicosatetraenoic acids.
R-BTA-2142691. Synthesis of Leukotrienes (LT) and Eoxins (EX).
R-BTA-2142700. Synthesis of Lipoxins (LX).

Miscellaneous databases

NextBioi20870076.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR001446. 5_LipOase_AP.
IPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]
PRINTSiPR00488. 5LPOXGNASEAP.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 25-150.

Entry informationi

Entry nameiLTC4S_BOVIN
AccessioniPrimary (citable) accession number: Q2NKS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 16, 2009
Last modified: February 17, 2016
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.