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Protein
Submitted name:

DDX11 protein

Gene

DDX11

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseSAAS annotation, Hydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
DDX11 proteinImported
Gene namesi
Name:DDX11Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27201.

PTM / Processingi

Proteomic databases

PaxDbiQ2NKM7.
PeptideAtlasiQ2NKM7.
PRIDEiQ2NKM7.

PTM databases

iPTMnetiQ2NKM7.

Expressioni

Gene expression databases

GenevisibleiQ2NKM7. HS.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 445Helicase ATP-bindingInterPro annotationAdd BLAST437

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili127 – 150Sequence analysisAdd BLAST24
Coiled coili153 – 180Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1133. Eukaryota.
COG1199. LUCA.
HOGENOMiHOG000241266.
HOVERGENiHBG058884.

Family and domain databases

InterProiView protein in InterPro
IPR006555. ATP-dep_Helicase_C.
IPR028331. DDX11/DDX12.
IPR010614. DEAD_2.
IPR013020. DNA_helicase_DNA-repair_Rad3.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR027417. P-loop_NTPase.
PANTHERiPTHR11472:SF44. PTHR11472:SF44. 1 hit.
PfamiView protein in Pfam
PF06733. DEAD_2. 1 hit.
PF13307. Helicase_C_2. 1 hit.
SMARTiView protein in SMART
SM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00604. rad3. 1 hit.
PROSITEiView protein in PROSITE
PS51193. HELICASE_ATP_BIND_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2NKM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANETQKVGA IHFPFPFTPY SIQEDFMAEL YRVLEAGKIG IFESPTGTGK
60 70 80 90 100
SLSLICGALS WLRDFEQKKR EEEARLLETG TGPLHDEKDE SLCLSSSCEG
110 120 130 140 150
AAGTPRPAGE PAWVTQFVQK KEERDLVDRL KAEQARRKQR EERLQQLQHR
160 170 180 190 200
VQLKYAAKRL RQEEEERENL LRLSREMLET GPEAERLEQL ESGEEELVLA
210 220 230 240 250
EYESDEEKKV ASRVDEDEDD LEEEHITKIY YCSRTHSQLA QFVHEVKKSP
260 270 280 290 300
FGKDVRLVSL GSRQNLCVNE DVKSLGSVQL INDRCVDMQR SRHEKKKGAE
310 320 330 340 350
EEKPKRRRQE KQAACPFYNH EQMGLLRDEA LAEVKDMEQL LALGKEARAC
360 370 380 390 400
PYYGSRLAIP AAQLVVLPYQ MLLHAATRQA AGIRLQDQVV IIDEAHNLID
410 420 430 440 450
TITGMHSVEV SGSQLCQAHS QLLQYVERYG KRLKAKNLMY LKQILYLLEK
460 470 480 490 500
FVAVLGGNIK QNPNTQSLSQ TGTELKTIND FLFQSQIDNI NLFKVQRYCE
510 520 530 540 550
KSMISRKLFG FTERYGAVFS SREQPKLAGF QQFLQSLQPR TTEALAAPAD
560 570 580 590 600
ESQASVPQPA SPLMHIEGFL AALTTANQDG RVILSRQGSL SQSTLKFLLL
610 620 630 640 650
NPAVHFAQVV KECRAVVIAG GTMQPVSDFR QQLLACAGVE AERVVEFSCG
660 670 680 690 700
HVIPPDNILP LVICIGVSNQ PLEFTFQKRD LPQMMDEVGR ILCNLCSVVS
710 720 730 740 750
GGVVCFFPSY EYLRQVHAHW EKGGLLGHLA ARKKIFQEPK SAHQVEQVLL
760 770 780 790 800
AYSRCIQACG QERGPVTGAL LLSVVGGKMS EGINFSDNLG RCVVMVGMPF
810 820 830 840 850
PNIRSAELQE KMAYLDQTLP RAPGQAPPGK ALVENLCMKA VNQSIGRAIR
860 870 880 890 900
HQKDFASIVL LDQRYARPPV LAKLPAWIRA RVEVKATFGP AIAAVQKFHR

EKSASS
Length:906
Mass (Da):101,622
Last modified:February 7, 2006 - v1
Checksum:i2C4916339682C62B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111733 mRNA. Translation: AAI11734.1.
RefSeqiNP_004390.3. NM_004399.2.
NP_085911.2. NM_030653.3.
NP_689651.1. NM_152438.1.
UniGeneiHs.443960.

Genome annotation databases

GeneIDi1663.

Similar proteinsi

Entry informationi

Entry nameiQ2NKM7_HUMAN
AccessioniPrimary (citable) accession number: Q2NKM7
Entry historyiIntegrated into UniProtKB/TrEMBL: February 7, 2006
Last sequence update: February 7, 2006
Last modified: September 27, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.