Q2NKJ3 (CTC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CST complex subunit CTC1

Alternative name(s):
Conserved telomere maintenance component 1
HBV DNAPTP1-transactivated protein B

Gene names

Name:	CTC1
Synonyms:	C17orf68

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1217 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. Ref.6 Ref.7
Subunit structure	Component of the CST complex, composed of TEN1/C17orf106, CTC1/C17orf68 and STN1/OBFC1. Interacts with STN1/OBFC1; the interaction is direct. Ref.6
Subcellular location	Nucleus. Chromosome › telomere. Note: A transmembrane region is predicted by sequence analysis tools (ESKW, MEMSAT and Phobius); however, given the telomeric localization of the protein, the relevance of the transmembrane region is unsure in vivo. Ref.6
Involvement in disease	Cerebroretinal microangiopathy with calcifications and cysts (CRMCC) [MIM:612199]: An autosomal recessive pleiomorphic disorder characterized primarily by intracranial calcifications, leukodystrophy, and brain cysts, resulting in spasticity, ataxia, dystonia, seizures, and cognitive decline. Patients also have retinal telangiectasia and exudates (Coats disease) as well as extraneurologic manifestations, including osteopenia with poor bone healing and a high risk of gastrointestinal bleeding and portal hypertension caused by vasculature ectasias in the stomach, small intestine, and liver. Some individuals also have hair, skin, and nail changes, as well as anemia and thrombocytopenia. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8 Ref.9
Sequence similarities	Belongs to the CTC1 family.
Sequence caution	The sequence BAB15247.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAD38600.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Chromosome Nucleus Telomere
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of DNA replication Inferred from sequence or structural similarity. Source: UniProtKB telomere maintenance Inferred from mutant phenotype Ref.7. Source: UniProtKB
Cellular_component	Stn1-Ten1 complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	single-stranded DNA binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q2NKJ3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q2NKJ3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     217-251: Missing.
     1053-1066: GKCTRLGSTCPTQT → APGGGWDCRSRGDL
     1067-1217: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1217	1217	CST complex subunit CTC1		PRO_0000287181
Natural variations
	Alternative sequence	217 – 251	35	Missing in isoform 2.		VSP_025351
	Alternative sequence	1053 – 1066	14	GKCTR…CPTQT → APGGGWDCRSRGDL in isoform 2.		VSP_025352
	Alternative sequence	1067 – 1217	151	Missing in isoform 2.		VSP_025353
	Natural variant	227	1	A → V in CRMCC. Ref.8		VAR_067369
	Natural variant	259	1	V → M in CRMCC. Ref.9		VAR_067370
	Natural variant	503	1	G → R in CRMCC. Ref.9		VAR_067371
	Natural variant	665	1	V → G in CRMCC. Ref.8		VAR_067372
	Natural variant	820	1	I → V. Corresponds to variant rs3027238 [ dbSNP | Ensembl ].		VAR_032282
	Natural variant	840	1	R → W in CRMCC. Ref.9		VAR_067373
	Natural variant	871	1	V → M in CRMCC. Ref.9		VAR_067374
	Natural variant	975	1	R → G in CRMCC. Ref.8 Ref.9		VAR_067375
	Natural variant	985	1	Missing in CRMCC. Ref.8 Ref.9		VAR_067376
	Natural variant	987	1	R → W in CRMCC. Ref.9		VAR_067377
	Natural variant	1005	1	I → V. Ref.1 Ref.2 Ref.3 Ref.5 Corresponds to variant rs3826543 [ dbSNP | Ensembl ].		VAR_032283
	Natural variant	1142	1	L → H in CRMCC. Ref.8		VAR_067378
	Natural variant	1196 – 1202	7	Missing in CRMCC.		VAR_067379
Experimental info
	Sequence conflict	41	1	L → V in CAD38600. Ref.2
	Sequence conflict	425	1	L → P in CAD38600. Ref.2
	Sequence conflict	668	1	S → I in ABE02809. Ref.1
	Sequence conflict	668	1	S → I in BAG52278. Ref.3
	Sequence conflict	864	1	S → G in CAD38600. Ref.2
	Sequence conflict	900	1	A → T in AAI10374. Ref.5
	Sequence conflict	964	1	G → E in CAD38600. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 23, 2010. Version 2. Checksum: EF6B3985C72FDA6E	FASTA	1,217	134,609
	10 20 30 40 50 60 MAAGRAQVPS SEQAWLEDAQ VFIQKTLCPA VKEPNVQLTP LVIDCVKTVW LSQGRNQGST 70 80 90 100 110 120 LPLSYSFVSV QDLKTHQRLP CCSHLSWSSS AYQAWAQEAG PNGNPLPREQ LLLLGTLTDL 130 140 150 160 170 180 SADLEQECRN GSLYVRDNTG VLSCELIDLD LSWLGHLFLF PRWSYLPPAR WNSSGEGHLE 190 200 210 220 230 240 LWDAPVPVFP LTISPGPVTP IPVLYPESAS CLLRLRNKLR GVQRNLAGSL VRLSALVKSK 250 260 270 280 290 300 QKAYFILSLG RSHPAVTHVS IIVQVPAQLV WHRALRPGTA YVLTELRVSK IRGQRQHVWM 310 320 330 340 350 360 TSQSSRLLLL KPECVQELEL ELEGPLLEAD PKPLPMPSNS EDKKDPESLV RYSRLLSYSG 370 380 390 400 410 420 AVTGVLNEPA GLYELDGQLG LCLAYQQFRG LRRVMRPGVC LQLQDVHLLQ SVGGGTRRPV 430 440 450 460 470 480 LAPCLRGAVL LQSFSRQKPG AHSSRQAYGA SLYEQLVWER QLGLPLYLWA TKALEELACK 490 500 510 520 530 540 LCPHVLRHHQ FLQHSSPGSP SLGLQLLAPT LDLLAPPGSP VRNAHNEILE EPHHCPLQKY 550 560 570 580 590 600 TRLQTPSSFP TLATLKEEGQ RKAWASFDPK ALLPLPEASY LPSCQLNRRL AWSWLCLLPS 610 620 630 640 650 660 AFCPAQVLLG VLVASSHKGC LQLRDQSGSL PCLLLAKHSQ PLSDPRLIGC LVRAERFQLI 670 680 690 700 710 720 VERDVRSSFP SWKELSMPGF IQKQQARVYV QFFLADALIL PVPRPCLHSA TPSTPQTDPT 730 740 750 760 770 780 GPEGPHLGQS RLFLLCHKEA LMKRNFCVPP GASPEVPKPA LSFYVLGSWL GGTQRKEGTG 790 800 810 820 830 840 WGLPEPQGND DNDQKVHLIF FGSSVRWFEF LHPGQVYRLI APGPATPMLF EKDGSSCISR 850 860 870 880 890 900 RPLELAGCAS CLTVQDNWTL ELESSQDIQD VLDANKSLPE SSLTDLLSDN FTDSLVSFSA 910 920 930 940 950 960 EILSRTLCEP LVASLWMKLG NTGAMRRCVK LTVALETAEC EFPPHLDVYI EDPHLPPSLG 970 980 990 1000 1010 1020 LLPGARVHFS QLEKRVSRSH NVYCCFRSST YVQVLSFPPE TTISIPLPHI YLAELLQGGQ 1030 1040 1050 1060 1070 1080 SPFQATASCH IVSVFSLQLF WVCAYCTSIC RQGKCTRLGS TCPTQTAISQ AIIRLLVEDG 1090 1100 1110 1120 1130 1140 TAEAVVTCRN HHVAAALGLC PREWASLLDF VQVPGRVVLQ FAGPGAQLES SARVDEPMTM 1150 1160 1170 1180 1190 1200 FLWTLCTSPS VLRPIVLSFE LERKPSKIVP LEPPRLQRFQ CGELPFLTHV NPRLRLSCLS 1210 IRESEYSSSL GILASSC
	Isoform 2 [UniParc]. Checksum: 4FDB851CDB123E45	FASTA	1,031	114,142
	10 20 30 40 50 60 MAAGRAQVPS SEQAWLEDAQ VFIQKTLCPA VKEPNVQLTP LVIDCVKTVW LSQGRNQGST 70 80 90 100 110 120 LPLSYSFVSV QDLKTHQRLP CCSHLSWSSS AYQAWAQEAG PNGNPLPREQ LLLLGTLTDL 130 140 150 160 170 180 SADLEQECRN GSLYVRDNTG VLSCELIDLD LSWLGHLFLF PRWSYLPPAR WNSSGEGHLE 190 200 210 220 230 240 LWDAPVPVFP LTISPGPVTP IPVLYPESAS CLLRLRSHPA VTHVSIIVQV PAQLVWHRAL 250 260 270 280 290 300 RPGTAYVLTE LRVSKIRGQR QHVWMTSQSS RLLLLKPECV QELELELEGP LLEADPKPLP 310 320 330 340 350 360 MPSNSEDKKD PESLVRYSRL LSYSGAVTGV LNEPAGLYEL DGQLGLCLAY QQFRGLRRVM 370 380 390 400 410 420 RPGVCLQLQD VHLLQSVGGG TRRPVLAPCL RGAVLLQSFS RQKPGAHSSR QAYGASLYEQ 430 440 450 460 470 480 LVWERQLGLP LYLWATKALE ELACKLCPHV LRHHQFLQHS SPGSPSLGLQ LLAPTLDLLA 490 500 510 520 530 540 PPGSPVRNAH NEILEEPHHC PLQKYTRLQT PSSFPTLATL KEEGQRKAWA SFDPKALLPL 550 560 570 580 590 600 PEASYLPSCQ LNRRLAWSWL CLLPSAFCPA QVLLGVLVAS SHKGCLQLRD QSGSLPCLLL 610 620 630 640 650 660 AKHSQPLSDP RLIGCLVRAE RFQLIVERDV RSSFPSWKEL SMPGFIQKQQ ARVYVQFFLA 670 680 690 700 710 720 DALILPVPRP CLHSATPSTP QTDPTGPEGP HLGQSRLFLL CHKEALMKRN FCVPPGASPE 730 740 750 760 770 780 VPKPALSFYV LGSWLGGTQR KEGTGWGLPE PQGNDDNDQK VHLIFFGSSV RWFEFLHPGQ 790 800 810 820 830 840 VYRLIAPGPA TPMLFEKDGS SCISRRPLEL AGCASCLTVQ DNWTLELESS QDIQDVLDAN 850 860 870 880 890 900 KSLPESSLTD LLSDNFTDSL VSFSAEILSR TLCEPLVASL WMKLGNTGAM RRCVKLTVAL 910 920 930 940 950 960 ETAECEFPPH LDVYIEDPHL PPSLGLLPGA RVHFSQLEKR VSRSHNVYCC FRSSTYVQVL 970 980 990 1000 1010 1020 SFPPETTISI PLPHIYLAEL LQGGQSPFQA TASCHIVSVF SLQLFWVCAY CTSICRQAPG 1030 GGWDCRSRGD L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Lun Y.Z., Cheng J., Guo J., Zhang L.Y., Zhao B.C. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-1005.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT VAL-1005. Tissue: Skeletal muscle.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-1005. Tissue: Corpus callosum and Kidney epithelium.
[4]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-1005. Tissue: Lung carcinoma and Uterine adenocarcinoma.
[6]	"RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway." Miyake Y., Nakamura M., Nabetani A., Shimamura S., Tamura M., Yonehara S., Saito M., Ishikawa F. Mol. Cell 36:193-206(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE CST COMPLEX, SUBCELLULAR LOCATION.
[7]	"Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes." Surovtseva Y.V., Churikov D., Boltz K.A., Song X., Lamb J.C., Warrington R., Leehy K., Heacock M., Price C.M., Shippen D.E. Mol. Cell 36:207-218(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[8]	"Mutations in CTC1, encoding the CTS telomere maintenance complex component 1, cause cerebroretinal microangiopathy with calcifications and cysts." Polvi A., Linnankivi T., Kivela T., Herva R., Keating J.P., Makitie O., Pareyson D., Vainionpaa L., Lahtinen J., Hovatta I., Pihko H., Lehesjoki A.E. Am. J. Hum. Genet. 90:540-549(2012) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS CRMCC VAL-227; GLY-665; GLY-975; CYS-985 DEL; HIS-1142 AND 1196-LEU--ARG-1202 DEL.
[9]	"Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus." Anderson B.H., Kasher P.R., Mayer J., Szynkiewicz M., Jenkinson E.M., Bhaskar S.S., Urquhart J.E., Daly S.B., Dickerson J.E., O'Sullivan J., Leibundgut E.O., Muter J., Abdel-Salem G.M., Babul-Hirji R., Baxter P., Berger A., Bonafe L., Brunstom-Hernandez J.E. , Buckard J.A., Chitayat D., Chong W.K., Cordelli D.M., Ferreira P., Fluss J., Forrest E.H., Franzoni E., Garone C., Hammans S.R., Houge G., Hughes I., Jacquemont S., Jeannet P.Y., Jefferson R.J., Kumar R., Kutschke G., Lundberg S., Lourenco C.M., Mehta R., Naidu S., Nischal K.K., Nunes L., Ounap K., Philippart M., Prabhakar P., Risen S.R., Schiffmann R., Soh C., Stephenson J.B., Stewart H., Stone J., Tolmie J.L., van der Knaap M.S., Vieira J.P., Vilain C.N., Wakeling E.L., Wermenbol V., Whitney A., Lovell S.C., Meyer S., Livingston J.H., Baerlocher G.M., Black G.C., Rice G.I., Crow Y.J. Nat. Genet. 44:338-342(2012) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS CRMCC MET-259; ARG-503; TRP-840; MET-871; GLY-975; CYS-985 DEL; TRP-987 AND 1196-LEU--ARG-1202 DEL.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ451688 mRNA. Translation: ABE02809.1. AL831955 mRNA. Translation: CAD38600.1. Different initiation. AK091077 mRNA. Translation: BAG52278.1. AC135178 Genomic DNA. No translation available. BC026057 mRNA. Translation: AAH26057.2. BC110373 mRNA. Translation: AAI10374.1. BC111783 mRNA. Translation: AAI11784.1. AK025823 mRNA. Translation: BAB15247.1. Different initiation.
IPI	IPI00018087. IPI00855745.
RefSeq	NP_079375.3. NM_025099.5.
UniGene	Hs.156055.
3D structure databases
ProteinModelPortal	Q2NKJ3.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-56900N.
IntAct	Q2NKJ3. 1 interaction.
STRING	9606.ENSP00000313759.
PTM databases
PhosphoSite	Q2NKJ3.
Polymorphism databases
DMDM	292495002.
Proteomic databases
PaxDb	Q2NKJ3.
PRIDE	Q2NKJ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000315684; ENSP00000313759; ENSG00000178971. ENST00000449476; ENSP00000396018; ENSG00000178971.
GeneID	80169.
KEGG	hsa:80169.
UCSC	uc002gkq.4. human.
Organism-specific databases
CTD	80169.
GeneCards	GC17M008154.
H-InvDB	HIX0019337.
HGNC	HGNC:26169. CTC1.
HPA	HPA044349.
MIM	612199. phenotype. 613129. gene.
neXtProt	NX_Q2NKJ3.
PharmGKB	PA142672251.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG39921.
HOVERGEN	HBG097256.
InParanoid	Q2NKJ3.
OMA	WLGHLFL.
OrthoDB	EOG44BB1D.
Gene expression databases
Bgee	Q2NKJ3.
CleanEx	HS_C17orf68.
Genevestigator	Q2NKJ3.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	CTC1. human.
GenomeRNAi	80169.
NextBio	70483.
SOURCE	Search...

Entry information

Entry name

CTC1_HUMAN

Accession

Primary (citable) accession number: Q2NKJ3
Secondary accession number(s): B3KR66 , C9JEX5, Q1PCD1, Q2TBE3, Q8N3S6, Q9H6L0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	March 23, 2010
Last modified:	May 1, 2013
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.