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Q2NKI2

- VAX1_MOUSE

UniProt

Q2NKI2 - VAX1_MOUSE

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Protein
Ventral anterior homeobox 1
Gene
Vax1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk.4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi100 – 15960Homeobox
Add
BLAST

GO - Molecular functioni

  1. chromatin DNA binding Source: MGI
  2. sequence-specific DNA binding transcription factor activity Source: MGI
  3. transcription regulatory region sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. axon guidance Source: MGI
  2. brain development Source: MGI
  3. camera-type eye development Source: MGI
  4. cell differentiation Source: MGI
  5. central nervous system development Source: MGI
  6. negative regulation of neuroblast proliferation Source: MGI
  7. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  8. nervous system development Source: MGI
  9. neuron migration Source: MGI
  10. palate development Source: MGI
  11. skeletal muscle cell differentiation Source: MGI
  12. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ventral anterior homeobox 1
Gene namesi
Name:Vax1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1277163. Vax1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Ventral anterior homeobox 1
PRO_0000240523Add
BLAST

Proteomic databases

PRIDEiQ2NKI2.

PTM databases

PhosphoSiteiQ2NKI2.

Expressioni

Developmental stagei

At 9.5 dpc, expressed in the forebrain, through the optic stalk and ending in the proximal portion of the optic vesicle. At 10.5 dpc, expressed in the optic stalk, outer layer of the optic cup, and the primordium of the pigment epithelium. In the pigment epithelium, down-regulated after 11.5 dpc, and expression restricted to the optic stalk and the ventral forebrain.2 Publications

Gene expression databases

BgeeiQ2NKI2.
CleanExiMM_VAX1.
GenevestigatoriQ2NKI2.

Structurei

3D structure databases

ProteinModelPortaliQ2NKI2.
SMRiQ2NKI2. Positions 102-157.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi216 – 27257Ala-rich
Add
BLAST

Sequence similaritiesi

Belongs to the EMX homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG323848.
GeneTreeiENSGT00750000117644.
HOGENOMiHOG000049217.
HOVERGENiHBG007558.
InParanoidiQ2NKI2.
KOiK09318.
OMAiASEDCNK.
PhylomeDBiQ2NKI2.
TreeFamiTF319504.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q2NKI2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFGKPDKMDV RCHSDTEAAR VSKNAHKESR EIKGAEGSLP AAFLKEPQGA    50
FSGSGASEDC NKSKSNSSAD PDYCRRILVR DAKGSIREII LPKGLDLDRP 100
KRTRTSFTAE QLYRLEMEFQ RCQYVVGRER TELARQLNLS ETQVKVWFQN 150
RRTKQKKDQG KDSELRSVVS ETAATCSVLR LLEQGRLLSP PGLPALLPPC 200
ATGALGSALR GPSLPALGAG AAAGSAAAAA AAAAATAPGP AGAASQHQPA 250
VGGAPGPGPA GPGGLHAGAP TASHGLFSLP VPSLLGSVAS RLSSAPLTMA 300
GSLAGNLQEL SARYLSSSAF EPYSRTNNKE GAEKKALD 338
Length:338
Mass (Da):35,167
Last modified:June 27, 2006 - v2
Checksum:i072986819244BB81
GO
Isoform 2 (identifier: Q2NKI2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-338: PSLPALGAGA...KEGAEKKALD → RTARGSTDCQ...GLRALLPDQQ

Note: No experimental confirmation available.

Show »
Length:276
Mass (Da):30,487
Checksum:i150DB6713DD86CE7
GO

Sequence cautioni

The sequence AAI11819.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei212 – 338127PSLPA…KKALD → RTARGSTDCQPRSLQPAGAV AARLCRQPPVLRPVDDGWFA SREFARTLSPLPELLGLRAL LPDQQ in isoform 2.
VSP_019397Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064554 mRNA. Translation: AAC36319.1.
AB020495 Genomic DNA. Translation: BAA76866.1.
BC111818 mRNA. Translation: AAI11819.1. Different initiation.
CCDSiCCDS29933.1. [Q2NKI2-1]
RefSeqiNP_033527.1. NM_009501.1. [Q2NKI2-1]
UniGeneiMm.23801.

Genome annotation databases

EnsembliENSMUST00000172821; ENSMUSP00000134642; ENSMUSG00000006270. [Q2NKI2-1]
GeneIDi22326.
KEGGimmu:22326.
UCSCiuc008ibg.1. mouse. [Q2NKI2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064554 mRNA. Translation: AAC36319.1 .
AB020495 Genomic DNA. Translation: BAA76866.1 .
BC111818 mRNA. Translation: AAI11819.1 . Different initiation.
CCDSi CCDS29933.1. [Q2NKI2-1 ]
RefSeqi NP_033527.1. NM_009501.1. [Q2NKI2-1 ]
UniGenei Mm.23801.

3D structure databases

ProteinModelPortali Q2NKI2.
SMRi Q2NKI2. Positions 102-157.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q2NKI2.

Proteomic databases

PRIDEi Q2NKI2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000172821 ; ENSMUSP00000134642 ; ENSMUSG00000006270 . [Q2NKI2-1 ]
GeneIDi 22326.
KEGGi mmu:22326.
UCSCi uc008ibg.1. mouse. [Q2NKI2-1 ]

Organism-specific databases

CTDi 11023.
MGIi MGI:1277163. Vax1.

Phylogenomic databases

eggNOGi NOG323848.
GeneTreei ENSGT00750000117644.
HOGENOMi HOG000049217.
HOVERGENi HBG007558.
InParanoidi Q2NKI2.
KOi K09318.
OMAi ASEDCNK.
PhylomeDBi Q2NKI2.
TreeFami TF319504.

Miscellaneous databases

NextBioi 302557.
PROi Q2NKI2.
SOURCEi Search...

Gene expression databases

Bgeei Q2NKI2.
CleanExi MM_VAX1.
Genevestigatori Q2NKI2.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain."
    Hallonet M., Hollemann T., Wehr R., Jenkins N.A., Copeland N.G., Pieler T., Gruss P.
    Development 125:2599-2610(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, DEVELOPMENTAL STAGE.
    Tissue: Brain.
  2. "Expression of the Vax family homeobox genes suggests multiple roles in eye development."
    Ohsaki K., Morimitsu T., Ishida Y., Kominami R., Takahashi N.
    Genes Cells 4:267-276(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), FUNCTION, DEVELOPMENTAL STAGE.
    Strain: BALB/c.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-338 (ISOFORM 2).
  4. "The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain."
    Bertuzzi S., Hindges R., Mui S.H., O'Leary D.D., Lemke G.
    Genes Dev. 13:3092-3105(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "A novel mechanism for the transcriptional regulation of Wnt signaling in development."
    Vacik T., Stubbs J.L., Lemke G.
    Genes Dev. 25:1783-1795(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiVAX1_MOUSE
AccessioniPrimary (citable) accession number: Q2NKI2
Secondary accession number(s): O88880
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: July 9, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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