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Protein

Ventral anterior homeobox 1

Gene

Vax1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk.4 Publications

Caution

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi100 – 159HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • chromatin DNA binding Source: MGI
  • DNA binding transcription factor activity Source: MGI
  • RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • axon guidance Source: MGI
  • brain development Source: MGI
  • camera-type eye development Source: MGI
  • cell differentiation Source: MGI
  • central nervous system development Source: MGI
  • negative regulation of neuroblast proliferation Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: NTNU_SB
  • nervous system development Source: MGI
  • neuron migration Source: MGI
  • palate development Source: MGI
  • skeletal muscle cell differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Ventral anterior homeobox 1
Gene namesi
Name:Vax1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1277163 Vax1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002405231 – 338Ventral anterior homeobox 1Add BLAST338

Proteomic databases

MaxQBiQ2NKI2
PaxDbiQ2NKI2
PRIDEiQ2NKI2

PTM databases

iPTMnetiQ2NKI2
PhosphoSitePlusiQ2NKI2

Expressioni

Developmental stagei

At 9.5 dpc, expressed in the forebrain, through the optic stalk and ending in the proximal portion of the optic vesicle. At 10.5 dpc, expressed in the optic stalk, outer layer of the optic cup, and the primordium of the pigment epithelium. In the pigment epithelium, down-regulated after 11.5 dpc, and expression restricted to the optic stalk and the ventral forebrain.2 Publications

Gene expression databases

BgeeiENSMUSG00000006270
CleanExiMM_VAX1
GenevisibleiQ2NKI2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000134642

Structurei

3D structure databases

ProteinModelPortaliQ2NKI2
SMRiQ2NKI2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi216 – 272Ala-richAdd BLAST57

Sequence similaritiesi

Belongs to the EMX homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0843 Eukaryota
ENOG4111SRW LUCA
GeneTreeiENSGT00910000144043
HOGENOMiHOG000049217
HOVERGENiHBG007558
InParanoidiQ2NKI2
KOiK09318
OMAiASEDCNK
OrthoDBiEOG091G0XAA
PhylomeDBiQ2NKI2
TreeFamiTF319504

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR000047 HTH_motif
IPR033020 Vax1
PANTHERiPTHR24339:SF32 PTHR24339:SF32, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2NKI2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGKPDKMDV RCHSDTEAAR VSKNAHKESR EIKGAEGSLP AAFLKEPQGA
60 70 80 90 100
FSGSGASEDC NKSKSNSSAD PDYCRRILVR DAKGSIREII LPKGLDLDRP
110 120 130 140 150
KRTRTSFTAE QLYRLEMEFQ RCQYVVGRER TELARQLNLS ETQVKVWFQN
160 170 180 190 200
RRTKQKKDQG KDSELRSVVS ETAATCSVLR LLEQGRLLSP PGLPALLPPC
210 220 230 240 250
ATGALGSALR GPSLPALGAG AAAGSAAAAA AAAAATAPGP AGAASQHQPA
260 270 280 290 300
VGGAPGPGPA GPGGLHAGAP TASHGLFSLP VPSLLGSVAS RLSSAPLTMA
310 320 330
GSLAGNLQEL SARYLSSSAF EPYSRTNNKE GAEKKALD
Length:338
Mass (Da):35,167
Last modified:June 27, 2006 - v2
Checksum:i072986819244BB81
GO
Isoform 2 (identifier: Q2NKI2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-338: PSLPALGAGA...KEGAEKKALD → RTARGSTDCQ...GLRALLPDQQ

Note: No experimental confirmation available.
Show »
Length:276
Mass (Da):30,487
Checksum:i150DB6713DD86CE7
GO

Sequence cautioni

The sequence AAI11819 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019397212 – 338PSLPA…KKALD → RTARGSTDCQPRSLQPAGAV AARLCRQPPVLRPVDDGWFA SREFARTLSPLPELLGLRAL LPDQQ in isoform 2. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064554 mRNA Translation: AAC36319.1
AB020495 Genomic DNA Translation: BAA76866.1
BC111818 mRNA Translation: AAI11819.1 Different initiation.
CCDSiCCDS29933.1 [Q2NKI2-1]
RefSeqiNP_033527.1, NM_009501.2 [Q2NKI2-1]
UniGeneiMm.23801

Genome annotation databases

EnsembliENSMUST00000172821; ENSMUSP00000134642; ENSMUSG00000006270 [Q2NKI2-1]
GeneIDi22326
KEGGimmu:22326
UCSCiuc008ibg.1 mouse [Q2NKI2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVAX1_MOUSE
AccessioniPrimary (citable) accession number: Q2NKI2
Secondary accession number(s): O88880
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: March 28, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome