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Protein

Glycosyltransferase 6 domain-containing protein 1

Gene

Glt6d1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei266 – 2661NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT6. Glycosyltransferase Family 6.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycosyltransferase 6 domain-containing protein 1 (EC:2.4.1.-)
Gene namesi
Name:Glt6d1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1918353. Glt6d1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55CytoplasmicSequence analysis
Transmembranei6 – 2621Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini27 – 311285LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Glycosyltransferase 6 domain-containing protein 1PRO_0000311973Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ2NKH9.
PaxDbiQ2NKH9.
PRIDEiQ2NKH9.

PTM databases

iPTMnetiQ2NKH9.
PhosphoSiteiQ2NKH9.

Expressioni

Gene expression databases

BgeeiQ2NKH9.
CleanExiMM_GLT6D1.
GenevisibleiQ2NKH9. MM.

Structurei

3D structure databases

ProteinModelPortaliQ2NKH9.
SMRiQ2NKH9. Positions 33-286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni85 – 906Substrate bindingBy similarity
Regioni176 – 1783Substrate bindingBy similarity
Regioni198 – 2014Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the glycosyltransferase 6 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHE7. Eukaryota.
ENOG4111IPQ. LUCA.
GeneTreeiENSGT00400000022032.
HOGENOMiHOG000234339.
HOVERGENiHBG003563.
InParanoidiQ2NKH9.
OMAiNTKNFPY.
OrthoDBiEOG79CZ05.
PhylomeDBiQ2NKH9.
TreeFamiTF330991.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005076. Glyco_trans_6.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR10462. PTHR10462. 1 hit.
PfamiPF03414. Glyco_transf_6. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2NKH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAKRRILLQ LLTFCLFLLL LAKIHFRNHQ EEELLLSDWF NPRRRLDVIT
60 70 80 90 100
TTDWLAPIIW EGTFDRKVLE TYFRKQNITV GLAVFAVGSL TDKYLDPFLQ
110 120 130 140 150
SASKFFMPGY RVIFYIMVDK YLQLQEMEHN PLQSFQVLKI GKERWWSNFD
160 170 180 190 200
LMRMKILSEH IRDHIRYEVD FLFSMNINMV FQSEFGVETL STSVAQLHPW
210 220 230 240 250
WYFRKRTNLP YERKPTSVAH IPFGLGDFYY AGAIIGGVPF QVLDFAQQYL
260 270 280 290 300
KGVFLDTENG VNSTYEKYLN KYFFLNKPTK LLSPEYSWDP TFNLPRHVWF
310
VKIAHHPIDT L
Length:311
Mass (Da):37,081
Last modified:February 7, 2006 - v1
Checksum:iD13B59C51C2552E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731682, BX649340 Genomic DNA. Translation: CAM14268.1.
BX649340, AL731682 Genomic DNA. Translation: CAM17955.1.
BC111823 mRNA. Translation: AAI11824.1.
CCDSiCCDS15791.1.
RefSeqiNP_001034184.1. NM_001039095.1.
UniGeneiMm.236431.

Genome annotation databases

EnsembliENSMUST00000038010; ENSMUSP00000048642; ENSMUSG00000036401.
GeneIDi71103.
KEGGimmu:71103.
UCSCiuc008itl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731682, BX649340 Genomic DNA. Translation: CAM14268.1.
BX649340, AL731682 Genomic DNA. Translation: CAM17955.1.
BC111823 mRNA. Translation: AAI11824.1.
CCDSiCCDS15791.1.
RefSeqiNP_001034184.1. NM_001039095.1.
UniGeneiMm.236431.

3D structure databases

ProteinModelPortaliQ2NKH9.
SMRiQ2NKH9. Positions 33-286.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT6. Glycosyltransferase Family 6.

PTM databases

iPTMnetiQ2NKH9.
PhosphoSiteiQ2NKH9.

Proteomic databases

MaxQBiQ2NKH9.
PaxDbiQ2NKH9.
PRIDEiQ2NKH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038010; ENSMUSP00000048642; ENSMUSG00000036401.
GeneIDi71103.
KEGGimmu:71103.
UCSCiuc008itl.1. mouse.

Organism-specific databases

CTDi360203.
MGIiMGI:1918353. Glt6d1.

Phylogenomic databases

eggNOGiENOG410IHE7. Eukaryota.
ENOG4111IPQ. LUCA.
GeneTreeiENSGT00400000022032.
HOGENOMiHOG000234339.
HOVERGENiHBG003563.
InParanoidiQ2NKH9.
OMAiNTKNFPY.
OrthoDBiEOG79CZ05.
PhylomeDBiQ2NKH9.
TreeFamiTF330991.

Miscellaneous databases

PROiQ2NKH9.
SOURCEiSearch...

Gene expression databases

BgeeiQ2NKH9.
CleanExiMM_GLT6D1.
GenevisibleiQ2NKH9. MM.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005076. Glyco_trans_6.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR10462. PTHR10462. 1 hit.
PfamiPF03414. Glyco_transf_6. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGL6D1_MOUSE
AccessioniPrimary (citable) accession number: Q2NKH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 7, 2006
Last modified: June 8, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.