ID   TPIS_AYWBP              Reviewed;         274 AA.
AC   Q2NIS7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=Triosephosphate isomerase;
DE            Short=TIM;
DE            EC=5.3.1.1;
DE   AltName: Full=Triose-phosphate isomerase;
GN   Name=tpiA; OrderedLocusNames=AYWB_549;
OS   Aster yellows witches'-broom phytoplasma (strain AYWB).
OC   Bacteria; Tenericutes; Mollicutes; Acholeplasmatales;
OC   Acholeplasmataceae; Candidatus Phytoplasma;
OC   Candidatus Phytoplasma asteris.
OX   NCBI_TaxID=322098;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16672622; DOI=10.1128/JB.188.10.3682-3696.2006;
RA   Bai X., Zhang J., Ewing A., Miller S.A., Jancso Radek A.,
RA   Shevchenko D.V., Tsukerman K., Walunas T., Lapidus A., Campbell J.W.,
RA   Hogenhout S.A.;
RT   "Living with genome instability: the adaptation of phytoplasmas to
RT   diverse environments of their insect and plant hosts.";
RL   J. Bacteriol. 188:3682-3696(2006).
CC   -!- CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate = glycerone
CC       phosphate.
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate from glycerone phosphate: step 1/1.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the triosephosphate isomerase family.
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DR   EMBL; CP000061; ABC65666.1; -; Genomic_DNA.
DR   RefSeq; YP_456745.1; -.
DR   GeneID; 3865964; -.
DR   GenomeReviews; CP000061_GR; AYWB_549.
DR   KEGG; ayw:AYWB_549; -.
DR   HOGENOM; Q2NIS7; -.
DR   OMA; Q2NIS7; CEETEAN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004807; F:triose-phosphate isomerase activity; IEA:HAMAP.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:HAMAP.
DR   GO; GO:0006096; P:glycolysis; IEA:HAMAP.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:HAMAP.
DR   HAMAP; MF_00147; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR000652; Triosephosphate_isomerase.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   PANTHER; PTHR21139; Triophos_ismrse; 1.
DR   Pfam; PF00121; TIM; 1.
DR   ProDom; PD001005; Triophos_ismrse; 1.
DR   TIGRFAMs; TIGR00419; tim; 1.
DR   PROSITE; PS00171; TIM_1; 1.
DR   PROSITE; PS51440; TIM_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase;
KW   Pentose shunt.
FT   CHAIN         1    274       Triosephosphate isomerase.
FT                                /FTId=PRO_1000009838.
FT   ACT_SITE     98     98       Electrophile (By similarity).
FT   ACT_SITE    170    170       Proton acceptor (By similarity).
FT   BINDING      13     13       Substrate (By similarity).
FT   BINDING      15     15       Substrate (By similarity).
SQ   SEQUENCE   274 AA;  30378 MW;  A4BE2AE8112AA1BB CRC64;
     MNYKPRTKVI AGNWKMHKCK DEALEFIQKV SLQVPDQTQV QTLIFPQLTL LDPLVQLQGA
     NLQVGAQNMF YETEGAFTGE VSPQNLLSLG VKHVLLGHSE RRTLFGETDQ TVNLKLLSAL
     KHKLVPTVCV GESLLTKENN QTQMFLDQQL TNIFAGVPEE ALKNMIIAYE PVWAIGTGKS
     ANPQDANKTI EQIREKVTAL YSFQASCAIR IIYGGSLSVA NIKSILEQPA IDGILAGKAS
     LQTEDFLFFA QIASKQVLVS TKDIFQKNDC PFCY
//