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Q2NIM1 (KITH_AYWBP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:tdk
Ordered Locus Names:AYWB_605
OrganismAster yellows witches'-broom phytoplasma (strain AYWB) [Complete proteome] [HAMAP]
Taxonomic identifier322098 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeCandidatus PhytoplasmaCandidatus Phytoplasma asteris

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00124

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00124.

Sequence similarities

Belongs to the thymidine kinase family.

Sequence caution

The sequence ABC65722.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processDNA synthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 209209Thymidine kinase HAMAP-Rule MF_00124
PRO_0000242787

Regions

Nucleotide binding16 – 238ATP By similarity
Nucleotide binding90 – 934ATP By similarity

Sites

Active site911Proton acceptor Potential

Sequences

Sequence LengthMass (Da)Tools
Q2NIM1 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: B82A9EA00E668308

FASTA20923,466
        10         20         30         40         50         60 
MTQKEQGQGF IEVICGPMFA GKTESLIQRR NKALKLKKKI LSFKPRIDDR YSVKEEIVSH 

        70         80         90        100        110        120 
NRNNIPAILI DKSKDILTFI TPEINVVIID ESQFLDNDII AIVDYLANCN IEVIISGLEL 

       130        140        150        160        170        180 
DFCGKPFGPM PYLLAIADTV TKLTSICAIS GGKANRTQRL IEGKPAQSNE PVVLVGGKEY 

       190        200 
HEPRCRKHHC LADIDKTKVN WKNFANQSK 

« Hide

References

[1]"Living with genome instability: the adaptation of phytoplasmas to diverse environments of their insect and plant hosts."
Bai X., Zhang J., Ewing A., Miller S.A., Jancso Radek A., Shevchenko D.V., Tsukerman K., Walunas T., Lapidus A., Campbell J.W., Hogenhout S.A.
J. Bacteriol. 188:3682-3696(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AYWB.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000061 Genomic DNA. Translation: ABC65722.1. Different initiation.
RefSeqYP_456801.1. NC_007716.1.

3D structure databases

ProteinModelPortalQ2NIM1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING322098.AYWB_605.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC65722; ABC65722; AYWB_605.
GeneID3865598.
KEGGayw:AYWB_605.
PATRIC21005276. VBIAstYel136969_0666.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1435.
HOGENOMHOG000076390.
KOK00857.
OrthoDBEOG69D3J2.

Enzyme and pathway databases

BioCycCPHY322098:GJ7E-643-MONOMER.

Family and domain databases

HAMAPMF_00124. Thymidine_kinase.
InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_AYWBP
AccessionPrimary (citable) accession number: Q2NIM1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: May 14, 2014
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families