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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMSTA339860:GJEZ-14-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Msp_0014
OrganismiMethanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Taxonomic identifieri339860 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanosphaera
ProteomesiUP000001931 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6021HelicalUniRule annotationAdd
BLAST
Transmembranei98 – 11821HelicalUniRule annotationAdd
BLAST
Transmembranei121 – 14121HelicalUniRule annotationAdd
BLAST
Transmembranei155 – 17521HelicalUniRule annotationAdd
BLAST
Transmembranei200 – 22021HelicalUniRule annotationAdd
BLAST
Transmembranei227 – 24721HelicalUniRule annotationAdd
BLAST
Transmembranei255 – 27521HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Undecaprenyl-diphosphatasePRO_0000250280Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi339860.Msp_0014.

Structurei

3D structure databases

ProteinModelPortaliQ2NIA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiAQCFALI.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2NIA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDILSAIIL GAVQGISEFL PISSSGHLVL VPALLGIETG LAFDTILHIG
60 70 80 90 100
TLVAIFTFFW KDIINLIKGF ILSIIDLTEG VDIFKRELHR VPEKRFAWLI
110 120 130 140 150
IVGTIPTGIM GILLKDAIET IFRGTLFVGI FLLVTAAVLY YSERHSSGQI
160 170 180 190 200
TQKDMSFKQA LIVGICQGLA VFPGISRSGS TIASGLCLGL NREYAARYSF
210 220 230 240 250
LLSIPAVIGA GLIQIKDIAT LDASASVLLA GFISSVIFGY LSIKLLMKMI
260 270
KGWSLDIFAY YCTIIGIITI ILSVVL
Length:276
Mass (Da):29,844
Last modified:February 7, 2006 - v1
Checksum:iD071A4FA2694CA1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000102 Genomic DNA. Translation: ABC56434.1.
RefSeqiWP_011405633.1. NC_007681.1.
YP_447077.1. NC_007681.1.

Genome annotation databases

EnsemblBacteriaiABC56434; ABC56434; Msp_0014.
GeneIDi3855640.
KEGGimst:Msp_0014.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000102 Genomic DNA. Translation: ABC56434.1.
RefSeqiWP_011405633.1. NC_007681.1.
YP_447077.1. NC_007681.1.

3D structure databases

ProteinModelPortaliQ2NIA2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi339860.Msp_0014.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC56434; ABC56434; Msp_0014.
GeneIDi3855640.
KEGGimst:Msp_0014.

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiAQCFALI.

Enzyme and pathway databases

BioCyciMSTA339860:GJEZ-14-MONOMER.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Methanosphaera stadtmanae reveals why this human intestinal archaeon is restricted to methanol and H2 for methane formation and ATP synthesis."
    Fricke W.F., Seedorf H., Henne A., Kruer M., Liesegang H., Hedderich R., Gottschalk G., Thauer R.K.
    J. Bacteriol. 188:642-658(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3.

Entry informationi

Entry nameiUPPP_METST
AccessioniPrimary (citable) accession number: Q2NIA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: February 7, 2006
Last modified: June 24, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.