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Protein

Probable L-tyrosine/L-aspartate decarboxylase

Gene

mfnA

Organism
Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.UniRule annotation

Catalytic activityi

L-tyrosine = tyramine + CO2.UniRule annotation
L-aspartate = beta-alanine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: methanofuran biosynthesis

This protein is involved in the pathway methanofuran biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway methanofuran biosynthesis and in Cofactor biosynthesis.

Pathwayi: coenzyme A biosynthesis

This protein is involved in the pathway coenzyme A biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00080
UPA00241

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-tyrosine/L-aspartate decarboxylaseUniRule annotation (EC:4.1.1.11UniRule annotation, EC:4.1.1.25UniRule annotation)
Short name:
TDC/ADCUniRule annotation
Gene namesi
Name:mfnAUniRule annotation
Ordered Locus Names:Msp_0329
OrganismiMethanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Taxonomic identifieri339860 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanosphaera
Proteomesi
  • UP000001931 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002931881 – 389Probable L-tyrosine/L-aspartate decarboxylaseAdd BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei233N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi339860.Msp_0329

Structurei

3D structure databases

ProteinModelPortaliQ2NHY7
SMRiQ2NHY7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family. MfnA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00027 Archaea
COG0076 LUCA
HOGENOMiHOG000246269
KOiK18933
OMAiDPHKMGL
OrthoDBiPOG093Z06IK

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01610 MfnA_decarbox, 1 hit
InterProiView protein in InterPro
IPR020931 MfnA
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03812 tyr_de_CO2_Arch, 1 hit

Sequencei

Sequence statusi: Complete.

Q2NHY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDKGRSKED VFRDLNVFHN MDMKYSSGRI LGSMCTKPDP VGLEAYKMFI
60 70 80 90 100
ETNLGDPGLF KGTALMEQEV INSLGNLLHL KNPCGHIVTG GTEANIMAMC
110 120 130 140 150
VAKYLYEEEN EGTPELILPK SAHFSFKKVL SMLSVKPVYV PLNNEYKIDV
160 170 180 190 200
TKLPDLITDN TMAMVGIAGT TELGLVDDIP EISKIAKSYG VYLHVDAALG
210 220 230 240 250
GFIIPFLNYK NNNQLNFDFK CKGVSSITID PHKMGLAPVP SGGIIFRKKK
260 270 280 290 300
YLEKLSIKTP YLTKDKQTTI VGTRTGASTA ATWTLLNYHG MEGYKKIVEK
310 320 330 340 350
VINLTTYTYN KLNKNKHVTI IHKPELNIIS FKVDNIDVDT LQKQLQAYGW
360 370 380
IVSLAEYPHV IRLVLMPHIK KEHIDEFLVD LDIIIQKNR
Length:389
Mass (Da):43,719
Last modified:February 7, 2006 - v1
Checksum:iCF043FAF923921B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000102 Genomic DNA Translation: ABC56739.1
RefSeqiWP_011405939.1, NC_007681.1

Genome annotation databases

EnsemblBacteriaiABC56739; ABC56739; Msp_0329
GeneIDi3854957
KEGGimst:Msp_0329

Similar proteinsi

Entry informationi

Entry nameiMFNA_METST
AccessioniPrimary (citable) accession number: Q2NHY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 7, 2006
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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