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Protein

Probable L-tyrosine/L-aspartate decarboxylase

Gene

mfnA

Organism
Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.UniRule annotation

Catalytic activityi

L-tyrosine = tyramine + CO2.UniRule annotation
L-aspartate = beta-alanine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: methanofuran biosynthesis

This protein is involved in the pathway methanofuran biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway methanofuran biosynthesis and in Cofactor biosynthesis.

Pathwayi: coenzyme A biosynthesis

This protein is involved in the pathway coenzyme A biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMSTA339860:GJEZ-329-MONOMER.
UniPathwayiUPA00080.
UPA00241.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-tyrosine/L-aspartate decarboxylaseUniRule annotation (EC:4.1.1.11UniRule annotation, EC:4.1.1.25UniRule annotation)
Short name:
TDC/ADCUniRule annotation
Gene namesi
Name:mfnAUniRule annotation
Ordered Locus Names:Msp_0329
OrganismiMethanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Taxonomic identifieri339860 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanosphaera
Proteomesi
  • UP000001931 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Probable L-tyrosine/L-aspartate decarboxylasePRO_0000293188Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei233 – 2331N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi339860.Msp_0329.

Structurei

3D structure databases

ProteinModelPortaliQ2NHY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family. MfnA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00027. Archaea.
COG0076. LUCA.
HOGENOMiHOG000246269.
KOiK18933.
OMAiAMELSRW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01610. MfnA_decarbox.
InterProiIPR020931. MfnA.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03812. tyr_de_CO2_Arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2NHY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDKGRSKED VFRDLNVFHN MDMKYSSGRI LGSMCTKPDP VGLEAYKMFI
60 70 80 90 100
ETNLGDPGLF KGTALMEQEV INSLGNLLHL KNPCGHIVTG GTEANIMAMC
110 120 130 140 150
VAKYLYEEEN EGTPELILPK SAHFSFKKVL SMLSVKPVYV PLNNEYKIDV
160 170 180 190 200
TKLPDLITDN TMAMVGIAGT TELGLVDDIP EISKIAKSYG VYLHVDAALG
210 220 230 240 250
GFIIPFLNYK NNNQLNFDFK CKGVSSITID PHKMGLAPVP SGGIIFRKKK
260 270 280 290 300
YLEKLSIKTP YLTKDKQTTI VGTRTGASTA ATWTLLNYHG MEGYKKIVEK
310 320 330 340 350
VINLTTYTYN KLNKNKHVTI IHKPELNIIS FKVDNIDVDT LQKQLQAYGW
360 370 380
IVSLAEYPHV IRLVLMPHIK KEHIDEFLVD LDIIIQKNR
Length:389
Mass (Da):43,719
Last modified:February 7, 2006 - v1
Checksum:iCF043FAF923921B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000102 Genomic DNA. Translation: ABC56739.1.
RefSeqiWP_011405939.1. NC_007681.1.

Genome annotation databases

EnsemblBacteriaiABC56739; ABC56739; Msp_0329.
GeneIDi3854957.
KEGGimst:Msp_0329.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000102 Genomic DNA. Translation: ABC56739.1.
RefSeqiWP_011405939.1. NC_007681.1.

3D structure databases

ProteinModelPortaliQ2NHY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi339860.Msp_0329.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC56739; ABC56739; Msp_0329.
GeneIDi3854957.
KEGGimst:Msp_0329.

Phylogenomic databases

eggNOGiarCOG00027. Archaea.
COG0076. LUCA.
HOGENOMiHOG000246269.
KOiK18933.
OMAiAMELSRW.

Enzyme and pathway databases

UniPathwayiUPA00080.
UPA00241.
BioCyciMSTA339860:GJEZ-329-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01610. MfnA_decarbox.
InterProiIPR020931. MfnA.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03812. tyr_de_CO2_Arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Methanosphaera stadtmanae reveals why this human intestinal archaeon is restricted to methanol and H2 for methane formation and ATP synthesis."
    Fricke W.F., Seedorf H., Henne A., Kruer M., Liesegang H., Hedderich R., Gottschalk G., Thauer R.K.
    J. Bacteriol. 188:642-658(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3.

Entry informationi

Entry nameiMFNA_METST
AccessioniPrimary (citable) accession number: Q2NHY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 7, 2006
Last modified: March 16, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.