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Q2NHN8 (Q2NHN8_METST) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP phosphoribosyltransferase HAMAP-Rule MF_00079
Short name=ATP-PRT HAMAP-Rule MF_00079
Short name=ATP-PRTase HAMAP-Rule MF_00079
EC=2.4.2.17 HAMAP-Rule MF_00079
Gene names
Name:hisG HAMAP-Rule MF_00079 EMBL ABC56595.1
Ordered Locus Names:Msp_0178
OrganismMethanosphaera stadtmanae (strain DSM 3091) [Complete proteome] [HAMAP]
Taxonomic identifier339860 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanosphaera ›

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity By similarity. HAMAP-Rule MF_00079

Catalytic activity

1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00079

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00079

Enzyme regulation

Feedback inhibited by histidine By similarity. HAMAP-Rule MF_00079

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. HAMAP-Rule MF_00079

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00079.

Sequence similarities

Belongs to the ATP phosphoribosyltransferase family. Long subfamily. HAMAP-Rule MF_00079

Sequences

Sequence LengthMass (Da)Tools
Q2NHN8 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 5D86695BD1FA8F8C

FASTA28931,518
        10         20         30         40         50         60 
MKVRIAIPSK GRISGPSVSL LEKAGIGLTD NSSRKLFSNT FDPEISVMFT RAADIPVYVA 

        70         80         90        100        110        120 
DGAADIGITG FDLTQEKNVD VEFLDDLKFG ATRLVVAAPE NSDFNTVDDL KNVKIVATEF 

       130        140        150        160        170        180 
PHLTQKYFEE KNINATIMPL SGATEVAPLI GVADVIADLT STGTTLKMNH LHEIDTIINS 

       190        200        210        220        230        240 
SVRLIANKES LKTKYEKIEA IRTGILGVLH AERKKLIMAN VHKSNLDDIK SAMPGMSGPT 

       250        260        270        280 
VSEVYGDENM VAVHSVISET EVFETINKLR KIGAKDLLVL PIERILENK

« Hide

References

[1]"The genome sequence of Methanosphaera stadtmanae reveals why this human intestinal archaeon is restricted to methanol and H2 for methane formation and ATP synthesis."
Fricke W.F., Seedorf H., Henne A., Kruer M., Liesegang H., Hedderich R., Gottschalk G., Thauer R.K.
J. Bacteriol. 188:642-658(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 3091.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000102 Genomic DNA. Translation: ABC56595.1.
RefSeqYP_447238.1. NC_007681.1.

3D structure databases

ProteinModelPortalQ2NHN8.
ModBaseSearch...

Protein-protein interaction databases

STRING339860.Msp_0178.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC56595; ABC56595; Msp_0178.
GeneID3855143.
KEGGmst:Msp_0178.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0040.
HOGENOMHOG000223247.
KOK00765.
OMAVATEFPN.
ProtClustDBPRK00489.

Enzyme and pathway databases

BioCycMSTA339860:GJEZ-178-MONOMER.
UniPathwayUPA00031; UER00006.

Family and domain databases

Gene3D3.30.70.120. 1 hit.
HAMAPMF_00079. HisG_Long.
InterProIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
PANTHERPTHR21403. PTHR21403. 1 hit.
PfamPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMSSF54913. N-reg_PII-like_a/b. 1 hit.
TIGRFAMsTIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ2NHN8_METST
AccessionPrimary (citable) accession number: Q2NHN8
Entry history
Integrated into UniProtKB/TrEMBL: February 7, 2006
Last sequence update: February 7, 2006
Last modified: May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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