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Q2NHB2

- RIBL_METST

UniProt

Q2NHB2 - RIBL_METST

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Protein
FAD synthase
Gene
ribL, Msp_0390
Organism
Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme By similarity.UniRule annotation

Catalytic activityi

ATP + FMN = diphosphate + FAD.UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei119 – 1191ATP; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi5 – 62ATP By similarity
Nucleotide bindingi10 – 134ATP By similarity
Nucleotide bindingi90 – 934ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. FMN adenylyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. FAD biosynthetic process Source: UniProtKB-HAMAP
  2. FMN metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

ATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSTA339860:GJEZ-390-MONOMER.
UniPathwayiUPA00277; UER00407.

Names & Taxonomyi

Protein namesi
Recommended name:
FAD synthase (EC:2.7.7.2)
Alternative name(s):
FMN adenylyltransferase
Flavin adenine dinucleotide synthase
Gene namesi
Name:ribL
Ordered Locus Names:Msp_0390
OrganismiMethanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Taxonomic identifieri339860 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanosphaera
ProteomesiUP000001931: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 148148FAD synthaseUniRule annotation
PRO_0000406271Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi339860.Msp_0390.

Structurei

3D structure databases

ProteinModelPortaliQ2NHB2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0615.
HOGENOMiHOG000284153.
KOiK14656.
OMAiIVLGHDQ.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_02115. FAD_synth_arch.
InterProiIPR004821. Cyt_trans-like.
IPR024902. FAD_synth_RibL.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2NHB2-1 [UniParc]FASTAAdd to Basket

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MASGTFDIIH PGHGFYLSES KKLGGDNAIL MVVVATDKTV KNHKRVPIVG    50
EKQRCEMVSM LKGVDEAYVG DEKDPFKIVK EKKPDIITIG PDQNFNPDSL 100
HKSLLKKGLD IKVVKINDYK KFELDSSCKI IRKIKQTDFD MDYLENCQ 148
Length:148
Mass (Da):16,744
Last modified:February 7, 2006 - v1
Checksum:i73288E85B05EA011
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000102 Genomic DNA. Translation: ABC56791.1.
RefSeqiYP_447434.1. NC_007681.1.

Genome annotation databases

EnsemblBacteriaiABC56791; ABC56791; Msp_0390.
GeneIDi3855755.
KEGGimst:Msp_0390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000102 Genomic DNA. Translation: ABC56791.1 .
RefSeqi YP_447434.1. NC_007681.1.

3D structure databases

ProteinModelPortali Q2NHB2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 339860.Msp_0390.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC56791 ; ABC56791 ; Msp_0390 .
GeneIDi 3855755.
KEGGi mst:Msp_0390.

Phylogenomic databases

eggNOGi COG0615.
HOGENOMi HOG000284153.
KOi K14656.
OMAi IVLGHDQ.

Enzyme and pathway databases

UniPathwayi UPA00277 ; UER00407 .
BioCyci MSTA339860:GJEZ-390-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_02115. FAD_synth_arch.
InterProi IPR004821. Cyt_trans-like.
IPR024902. FAD_synth_RibL.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF01467. CTP_transf_2. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Methanosphaera stadtmanae reveals why this human intestinal archaeon is restricted to methanol and H2 for methane formation and ATP synthesis."
    Fricke W.F., Seedorf H., Henne A., Kruer M., Liesegang H., Hedderich R., Gottschalk G., Thauer R.K.
    J. Bacteriol. 188:642-658(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3.

Entry informationi

Entry nameiRIBL_METST
AccessioniPrimary (citable) accession number: Q2NHB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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