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Protein

Ribonuclease P protein component 4

Gene

rnp4

Organism
Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi63ZincUniRule annotation1
Metal bindingi66ZincUniRule annotation1
Metal bindingi89ZincUniRule annotation1
Metal bindingi92ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein component 4UniRule annotation (EC:3.1.26.5UniRule annotation)
Short name:
RNase P component 4UniRule annotation
Alternative name(s):
Rpp21UniRule annotation
Gene namesi
Name:rnp4UniRule annotation
Ordered Locus Names:Msp_0592
OrganismiMethanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Taxonomic identifieri339860 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanosphaera
Proteomesi
  • UP000001931 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000466341 – 104Ribonuclease P protein component 4Add BLAST104

Interactioni

Subunit structurei

Consists of a catalytic RNA component and at least 4-5 protein subunits.UniRule annotation

Protein-protein interaction databases

STRINGi339860.Msp_0592.

Structurei

3D structure databases

ProteinModelPortaliQ2NGR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic/archaeal RNase P protein component 4 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04345. Archaea.
COG2023. LUCA.
HOGENOMiHOG000230709.
KOiK03540.
OMAiWINTIAL.

Family and domain databases

HAMAPiMF_00757. RNase_P_4. 1 hit.
InterProiIPR016432. RNase_P_comp-4.
IPR007175. Rpr2.
[Graphical view]
PfamiPF04032. Rpr2. 1 hit.
[Graphical view]
PIRSFiPIRSF004878. RNase_P_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2NGR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRKRPNWI NTIALERMQI LFEQAEKEFS KHPERSDRYV KLTRNISTKY
60 70 80 90 100
NIPLPNYWRG RFCKNCNKFL KPGSNLRVRL SNNTISRKCL ECGDLKKVPY

TKKN
Length:104
Mass (Da):12,507
Last modified:February 7, 2006 - v1
Checksum:i294B4037C84F6BB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000102 Genomic DNA. Translation: ABC56990.1.
RefSeqiWP_011406190.1. NC_007681.1.

Genome annotation databases

EnsemblBacteriaiABC56990; ABC56990; Msp_0592.
GeneIDi3855878.
KEGGimst:Msp_0592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000102 Genomic DNA. Translation: ABC56990.1.
RefSeqiWP_011406190.1. NC_007681.1.

3D structure databases

ProteinModelPortaliQ2NGR3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi339860.Msp_0592.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC56990; ABC56990; Msp_0592.
GeneIDi3855878.
KEGGimst:Msp_0592.

Phylogenomic databases

eggNOGiarCOG04345. Archaea.
COG2023. LUCA.
HOGENOMiHOG000230709.
KOiK03540.
OMAiWINTIAL.

Family and domain databases

HAMAPiMF_00757. RNase_P_4. 1 hit.
InterProiIPR016432. RNase_P_comp-4.
IPR007175. Rpr2.
[Graphical view]
PfamiPF04032. Rpr2. 1 hit.
[Graphical view]
PIRSFiPIRSF004878. RNase_P_4. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRNP4_METST
AccessioniPrimary (citable) accession number: Q2NGR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: November 2, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.