Q2NGK6 (HIS3_METST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-AMP cyclohydrolase
Short name=PRA-CH
EC=3.5.4.19

Gene names

Name:	hisI
Ordered Locus Names:	Msp_0649

Organism

Methanosphaera stadtmanae (strain DSM 3091) [Complete proteome] [HAMAP]

Taxonomic identifier

339860 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanosphaera

Protein attributes

Sequence length	129 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP MF_01021
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP MF_01021
Subcellular location	Cytoplasm By similarity HAMAP MF_01021.
Sequence similarities	Belongs to the PRA-CH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphoribosyl-AMP cyclohydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 129	129	Phosphoribosyl-AMP cyclohydrolase HAMAP MF_01021		PRO_0000319733

Sequences

	Sequence		Length	Mass (Da)
	Q2NGK6 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 0A260DE75C468B94	FASTA	129	14,950
	10 20 30 40 50 60 MIKPNFRHII NGKRLATAIA QDYKTGEILM VAFIDEEAFN KTIQTRKAHY YSTSRNMIWY 70 80 90 100 110 120 KGEESGHIQE IKEVLLDCDE DAIIFKVKQV GGACHTGHYS CFYKKLSDDG EVVTEYEDKV FDPEDVYEK

References

[1]

"The genome sequence of Methanosphaera stadtmanae reveals why this human intestinal archaeon is restricted to methanol and H2 for methane formation and ATP synthesis." Fricke W.F., Seedorf H., Henne A., Kruer M., Liesegang H., Hedderich R., Gottschalk G., Thauer R.K. J. Bacteriol. 188:642-658(2006) [PubMed: 16385054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 3091.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000102 Genomic DNA. Translation: ABC57047.1.
RefSeq	YP_447690.1. NC_007681.1.
3D structure databases
ProteinModelPortal	Q2NGK6.
SMR	Q2NGK6. Positions 2-123.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2NGK6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3855438.
GenomeReviews	Gene locus Msp_0649 in contig CP000102_GR.
KEGG	mst:Msp_0649.
NMPDR	fig|339860.6.peg.629.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG12274.
HOGENOM	HBG294308.
OMA	VLMVGHM.
PhylomeDB	Q2NGK6.
ProtClustDB	PRK00051.
Enzyme and pathway databases
BioCyc	MSTA339860:MSP_0649-MONOMER.
Family and domain databases
HAMAP	MF_01021. HisI. [Tree]
InterPro	IPR002496. PRib_AMP_CycHydrolase. [Graphical view]
KO	K01496.
Pfam	PF01502. PRA-CH. 1 hit. [Graphical view]
ProDom	PD002610. PRA_CycHdrlase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

HIS3_METST

Accession

Primary (citable) accession number: Q2NGK6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 7, 2006
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program