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Q2NGG1 (THIM2_METST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase 2

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase 2
Short name=TH kinase 2
Short name=Thz kinase 2
Gene names
Name:thiM2
Ordered Locus Names:Msp_0694
OrganismMethanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3) [Complete proteome] [HAMAP]
Taxonomic identifier339860 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanosphaera

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 282282Hydroxyethylthiazole kinase 2 HAMAP-Rule MF_00228
PRO_0000383919

Sites

Binding site441Substrate; via amide nitrogen By similarity
Binding site1201ATP By similarity
Binding site1791ATP By similarity
Binding site2061Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2NGG1 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: AE7653BD0E02A1AA

FASTA28230,324
        10         20         30         40         50         60 
MLEQCSKNIE KLRNKCPLTH CITNYVTIND CANVVLAIGG SPAMANEAPE IEEFVEAAGV 

        70         80         90        100        110        120 
TIINMGTLLE DQIEPMQIAA CHTKKTNTPL VLDPVAVGVS KLRNDITIDL INKSSVDVIR 

       130        140        150        160        170        180 
GNMSEIKAIA NLFNITDEKS VAKGVDVSSD DIITKDNIKS NASLVKAVAD KLNTTIAVSG 

       190        200        210        220        230        240 
AIDIISDGVS IYLIDNGEEV MSKITGSGCM LTCVIGSFCA ITSPLEAAII GSLSMAISGE 

       250        260        270        280 
LARRKMEINN EGSGSFRTYL IDMMYNMNDE TIMKYGKLYK LE 

« Hide

References

[1]"The genome sequence of Methanosphaera stadtmanae reveals why this human intestinal archaeon is restricted to methanol and H2 for methane formation and ATP synthesis."
Fricke W.F., Seedorf H., Henne A., Kruer M., Liesegang H., Hedderich R., Gottschalk G., Thauer R.K.
J. Bacteriol. 188:642-658(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000102 Genomic DNA. Translation: ABC57092.1.
RefSeqYP_447735.1. NC_007681.1.

3D structure databases

ProteinModelPortalQ2NGG1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING339860.Msp_0694.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC57092; ABC57092; Msp_0694.
GeneID3855843.
KEGGmst:Msp_0694.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMAFDENIEM.
ProtClustDBCLSK843662.

Enzyme and pathway databases

BioCycMSTA339860:GJEZ-694-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
ProtoNetSearch...

Entry information

Entry nameTHIM2_METST
AccessionPrimary (citable) accession number: Q2NGG1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: February 7, 2006
Last modified: February 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways