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Protein

Hydroxyethylthiazole kinase 2

Gene

thiM2

Organism
Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Hydroxyethylthiazole kinase 1 (thiM1), Hydroxyethylthiazole kinase 2 (thiM2)
This subpathway is part of the pathway thiamine diphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole, the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44Substrate; via amide nitrogenUniRule annotation1
Binding sitei120ATPUniRule annotation1
Binding sitei179ATPUniRule annotation1
Binding sitei206Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processThiamine biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00060; UER00139

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase 2UniRule annotation (EC:2.7.1.50UniRule annotation)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase 2UniRule annotation
Short name:
TH kinase 2UniRule annotation
Short name:
Thz kinase 2UniRule annotation
Gene namesi
Name:thiM2UniRule annotation
Ordered Locus Names:Msp_0694
OrganismiMethanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Taxonomic identifieri339860 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanosphaera
Proteomesi
  • UP000001931 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003839191 – 282Hydroxyethylthiazole kinase 2Add BLAST282

Proteomic databases

PRIDEiQ2NGG1

Interactioni

Protein-protein interaction databases

STRINGi339860.Msp_0694

Structurei

3D structure databases

ProteinModelPortaliQ2NGG1
SMRiQ2NGG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00019 Archaea
COG2145 LUCA
HOGENOMiHOG000114352
KOiK00878
OMAiSINDCAN
OrthoDBiPOG093Z0A6M

Family and domain databases

CDDicd01170 THZ_kinase, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_00228 Thz_kinase, 1 hit
InterProiView protein in InterPro
IPR000417 Hyethyz_kinase
IPR029056 Ribokinase-like
PANTHERiPTHR44423 PTHR44423, 1 hit
PfamiView protein in Pfam
PF02110 HK, 1 hit
PIRSFiPIRSF000513 Thz_kinase, 1 hit
PRINTSiPR01099 HYETHTZKNASE
SUPFAMiSSF53613 SSF53613, 1 hit

Sequencei

Sequence statusi: Complete.

Q2NGG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEQCSKNIE KLRNKCPLTH CITNYVTIND CANVVLAIGG SPAMANEAPE
60 70 80 90 100
IEEFVEAAGV TIINMGTLLE DQIEPMQIAA CHTKKTNTPL VLDPVAVGVS
110 120 130 140 150
KLRNDITIDL INKSSVDVIR GNMSEIKAIA NLFNITDEKS VAKGVDVSSD
160 170 180 190 200
DIITKDNIKS NASLVKAVAD KLNTTIAVSG AIDIISDGVS IYLIDNGEEV
210 220 230 240 250
MSKITGSGCM LTCVIGSFCA ITSPLEAAII GSLSMAISGE LARRKMEINN
260 270 280
EGSGSFRTYL IDMMYNMNDE TIMKYGKLYK LE
Length:282
Mass (Da):30,324
Last modified:February 7, 2006 - v1
Checksum:iAE7653BD0E02A1AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000102 Genomic DNA Translation: ABC57092.1
RefSeqiWP_011406292.1, NC_007681.1

Genome annotation databases

EnsemblBacteriaiABC57092; ABC57092; Msp_0694
GeneIDi3855843
KEGGimst:Msp_0694

Similar proteinsi

Entry informationi

Entry nameiTHIM2_METST
AccessioniPrimary (citable) accession number: Q2NGG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: February 7, 2006
Last modified: April 25, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health